{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:09Z","timestamp":1772168949659,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.161261.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000}}],"reference-count":47,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Natural products databases are well-structured data sources that offer new molecular development opportunities in drug discovery, agrochemistry, food, cosmetics, and several other research disciplines or chemical industries. The crescent world\u2019s interest in the development of these databases is related to the exploration of chemical diversity in geographical regions with rich biodiversity. Methods In this work, we introduce and discuss Nat-UV DB, the first natural products database from a coastal zone of Mexico. We discuss its construction, curation, and chemoinformatic characterization of their content, and chemical space coverage compared with other compound databases, like approved drugs, and other Mexican (BIOFACQUIM and UNIIQUIM databases) and the Latin American natural products database (LaNAPDB). Results Nat-UV DB comprises 227 compounds that contain 112 scaffolds, of which 52 are not present in previous natural product databases. The compounds present in Nat-UV DB have a similar size, flexibility, and polarity to previously reported natural products and approved drug datasets. Conclusions Nat-UV DB compounds have a higher structural and scaffold diversity than the approved drugs, but they have low structural and scaffold diversity in contrast with other natural products in the reference datasets. This database serves as a valuable addition to the global natural products landscape, bridging gaps in exploring biodiversity-rich regions.<\/ns3:p>","DOI":"10.12688\/f1000research.161261.2","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T12:10:08Z","timestamp":1745496608000},"page":"157","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nat-UV DB: A Natural Products Database Underlying of Veracruz-Mexico"],"prefix":"10.12688","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7422-6059","authenticated-orcid":false,"given":"Edgar","family":"L\u00f3pez-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Margarita","family":"Hern\u00e1ndez-Segura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Lara-Cuellar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-8980","authenticated-orcid":false,"given":"Carolina","family":"Barrientos-Salcedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos M.","family":"Cerda-Garc\u00eda-Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4940-1107","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Medina-Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1101-1121","DOI":"10.1023\/B:BIOC.0000018147.54695.b3","article-title":"Endemic species of grasses in Mexico: a phytogeographic approach.","volume":"13","author":"P D\u00e1vila-Aranda","year":"2004","journal-title":"Biodivers. 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The datasets used in this work.","author":"J Medina-Franco","year":"2025"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.14715820","article-title":"Source code.","author":"J Medina-Franco","year":"2025","journal-title":"Archived software."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/14-157\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/14-157\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/14-157\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T12:10:10Z","timestamp":1745496610000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/14-157\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":47,"URL":"https:\/\/doi.org\/10.12688\/f1000research.161261.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.161261.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.180801.r380595","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,24]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/14-157\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.177266.r370994, Virginia Flores-Morales, The Autonomous University of Zacatecas, Zacatecas, 20 Mar 2025, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/14-157\/v1#referee-response-370994","order":0,"name":"referee-response-370994","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.177266.r370987, David J Newman, NIH Special Volunteer, Wayne, 02 Apr 2025, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/14-157\/v1#referee-response-370987","order":1,"name":"referee-response-370987","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.177266.r370989, Kathia Maria Honorio, Universidade de Sao Paulo, S\u00e3o Paulo, State of S\u00e3o Paulo, 12 Apr 2025, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/14-157\/v1#referee-response-370989","order":2,"name":"referee-response-370989","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Jos&eacute; L. Medina-Franco<\/b>; \n<i>Posted: 16 Apr 2025<\/i>; Dear Prof. Kathia Maria Honorio, We appreciate your valuable comments and suggestions. The second version of this revised work addresses all of them.","URL":"https:\/\/f1000research.com\/articles\/14-157\/v2#referee-comment-13756","order":3,"name":"referee-comment-13756","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}