{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:11:44Z","timestamp":1783357904462,"version":"3.54.6"},"reference-count":22,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns5:p>Background Dentigerous cysts are benign, non-inflammatory odontogenic cysts that form over unerupted or partially erupted teeth. They are the second most common type of odontogenic cysts and can cause various complications if left untreated. Methods We report a rare case of bilateral dentigerous cysts in the mandible of a 13-year-old boy. Radiographic examination revealed two cysts on each mandibular side, associated with developing third molars and unerupted permanent second premolars. Histopathological examination confirmed the diagnosis of dentigerous cysts. Results The patient underwent surgical enucleation of all cysts and extraction of unerupted teeth under general anesthesia. The postoperative course was uneventful, with no recurrence observed over a 2-year follow-up period. Conclusions Dentigerous cysts are rare in children and even rarer in bilateral presentation. Early diagnosis and treatment are essential to prevent potential complications such as infection, tooth displacement, jaw fracture, or malignant transformation. This case illustrates the importance of radiographic examination and histopathological confirmation in the management of dentigerous cysts.<\/ns5:p>","DOI":"10.12688\/f1000research.161532.1","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T09:45:07Z","timestamp":1739785507000},"page":"215","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report : Bilateral dentigerous cysts in association with developing third molars and premolars in a non-syndromic 13-year-old: a 2-year follow-up"],"prefix":"10.12688","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-7737","authenticated-orcid":false,"given":"Osama","family":"Zakaria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0155-5035","authenticated-orcid":false,"given":"Sami","family":"Alshehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"795-800","DOI":"10.3109\/00016357.2014.913192","article-title":"Prevalence of Developmental Odontogenic Cysts in Children and Adolescents with Emphasis on Dentigerous Cyst and Odontogenic Keratocyst (Keratocystic Odontogenic Tumor).","volume":"72","author":"N Li","year":"2014","journal-title":"Acta Odontol. Scand."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5455\/jrmds.20175211","article-title":"What Do We Know About Dentigerous Cysts in Children A Review of Literature.","volume":"5","author":"N Khzam","year":"2017","journal-title":"J. Res. Med. Dent. Sci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1148-1151","DOI":"10.12659\/AJCR.917943","article-title":"Bilateral Mandibular Dentigerous Cysts Presenting as an Incidental Finding: A Case Report.","author":"K Aziz","year":"2019"},{"key":"ref4","first-page":"75-76","article-title":"Spontaneous Regression of Bilateral Dentigerous Cysts Associated with Impacted Mandibular Third Molars.","volume":"192","author":"N Shah","year":"2002"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"63-65","DOI":"10.12968\/denu.2008.35.1.63","article-title":"Spontaneous Regression of Bilateral Dentigerous Cysts: A Case Report.","volume":"35","author":"Y Chew","year":"2008","journal-title":"Dent. 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Oral Epidemiol. 8AD."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3892\/ETM.2021.10182","article-title":"Management of Large Inflammatory Dentigerous Cysts Adapted to the General Condition of the Patient: Two Case Reports.","volume":"22","author":"A Vinereanu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"171-174","DOI":"10.1007\/s12105-010-0238-7","article-title":"A Rare Case of Dentigerous Cyst in a One Year Old Child: The Earliest Known Reported Occurrence.","volume":"5","author":"R Suresh","year":"2011","journal-title":"Head Neck Pathol."},{"key":"ref11","first-page":"1-3","article-title":"Simultaneous Bilateral Dentigerous Cysts at the Mandibular Notch with Ectopic Third Molars: A Case Report.","volume":"9","author":"A Sugauchi","year":"2023"},{"key":"ref12","first-page":"57-61","article-title":"Bilateral Dentigerous Cysts of the Permanent Mandibular First Molars Treated with Marsu-pialization.","volume":"90","author":"A Urs","year":"2023","journal-title":"J. Dent. Child."},{"key":"ref13","first-page":"52-55","article-title":"Nonsyndromic Bilateral Mandibular Dentigerous Cyst: A Case Report.","volume":"53","author":"A Ozkan","year":"2011","journal-title":"Gulhane Med. J."},{"key":"ref14","first-page":"4-8","article-title":"Multiple Dentigerous Cysts: Two Case Reports of Nonsyndromic Twins.","author":"R Catarina","year":"2019"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e38623","DOI":"10.5812\/AJDR.38623","article-title":"Cone Beam Computed Tomography Finding of Unusual Bilateral Dentigerous Cysts in a Nonsyndromic Patient: A Case Report. Avicenna.","volume":"9","author":"M Esmaelizadeh","year":"2016","journal-title":"J. Dent. Res."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"579-586","DOI":"10.25122\/jml-2021-0288","article-title":"A Novel Approach in Diagnosing Multiple Dentigerous Cysts Using CBCT Illustration Indicative of Mucopolysaccharidosis VI - a Case Report.","volume":"15","author":"S Rai","year":"2022","journal-title":"J. Med. Life."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"169-175","DOI":"10.1016\/0030-4220(84)90133-6","article-title":"Occurrence of Multiple Dentigerous Cysts in a Patient with the Maroteaux-Lamy Syndrome (Mucopolysaccharidosis, Type VI).","volume":"58","author":"M Roberts","year":"1984","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"177-181","DOI":"10.17796\/jcpd.28.2.m21q8vx78084374v","article-title":"Bilateral Dentigerous Cyst Associated with Polymorphism in Chromosome 1qh+.","volume":"28","author":"P Batra","year":"2004","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"109","DOI":"10.32793\/jrdi.v6i3.918","article-title":"Bilateral Radicular Cyst Mimicking Dentigerous Cyst: A Case Report.","volume":"6","author":"K Anjani","year":"2022","journal-title":"J. Radiol. 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