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The diagnosis of kidney disease usually involves the biochemical analysis of serum and blood, but these tests are often insufficiently sensitive or specific to make a definitive diagnosis. Although radiologic imaging currently has a limited role in the evaluation of most kidney diseases, several new imaging methods hold great promise for improving our ability to non-invasively detect structural, functional, and molecular changes within the kidney. New methods, such as dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and blood oxygen level-dependent (BOLD) MRI, allow functional imaging of the kidney. The use of novel contrast agents, such as microbubbles and nanoparticles, allows the detection of specific molecules in the kidney. These methods could greatly advance our ability to diagnose disease and also to safely monitor patients over time. This could improve the care of individual patients, and it could also facilitate the evaluation of new treatment strategies.<\/ns4:p>","DOI":"10.12688\/f1000research.16188.1","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T09:15:44Z","timestamp":1543482944000},"page":"1867","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Recent advances in renal imaging"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3476-9956","authenticated-orcid":false,"given":"Joshua M.","family":"Thurman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faikah","family":"Gueler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"46-52","DOI":"10.2379\/CN106407","article-title":"Ultrasound as a diagnostic tool to differentiate acute from chronic renal failure.","volume":"74","author":"C Ozmen","year":"2010","journal-title":"Clin Nephrol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1227-36","DOI":"10.2174\/156802610791384225","article-title":"Design and development of molecular imaging probes.","volume":"10","author":"K Chen","year":"2010","journal-title":"CTMC."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"382-94","DOI":"10.2215\/CJN.04840513","article-title":"Renal relevant radiology: Use of ultrasonography in patients with AKI.","volume":"9","author":"S Faubel","year":"2014","journal-title":"Clin J Am Soc Nephrol."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"2845-55","DOI":"10.1007\/s00330-017-5246-5","article-title":"Post-contrast acute kidney injury - Part 1: Definition, clinical features, incidence, role of contrast medium and risk factors: Recommendations for updated ESUR Contrast Medium Safety Committee guidelines.","volume":"28","author":"A van der Molen","year":"2018","journal-title":"Eur Radiol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"2856-69","DOI":"10.1007\/s00330-017-5247-4","article-title":"Post-contrast acute kidney injury. 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Soulez","year":"2015","journal-title":"AJR Am J Roentgenol."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"701-5","DOI":"10.1097\/RLI.0000000000000259","article-title":"Incidence of Nephrogenic Systemic Fibrosis Using Gadobenate Dimeglumine in 1423 Patients With Renal Insufficiency Compared With Gadodiamide.","volume":"51","author":"R Bruce","year":"2016","journal-title":"Invest Radiol."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"55-60","DOI":"10.1097\/RLI.0000000000000307","article-title":"Gadobutrol in Renally Impaired Patients: Results of the GRIP Study.","volume":"52","author":"H Michaely","year":"2017","journal-title":"Invest Radiol."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"2122-30","DOI":"10.1056\/NEJMoa054341","article-title":"Volume progression in polycystic kidney disease.","volume":"354","author":"J Grantham","year":"2006","journal-title":"N Engl J 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Kopp","year":"2012","journal-title":"Hypertension."},{"key":"ref-43","doi-asserted-by":"publisher","first-page":"125-31","DOI":"10.1016\/j.cmet.2012.11.013","article-title":"Long-term space flight simulation reveals infradian rhythmicity in human Na+ balance.","volume":"17","author":"N Rakova","year":"2013","journal-title":"Cell Metab."},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"635-40","DOI":"10.1161\/HYPERTENSIONAHA.111.00566","article-title":"23Na magnetic resonance imaging-determined tissue sodium in healthy subjects and hypertensive patients.","volume":"61","author":"C Kopp","year":"2013","journal-title":"Hypertension."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"101-5","DOI":"10.1097\/01.mnh.0000441151.55320.c3","article-title":"Sodium balance is not just a renal affair.","volume":"23","author":"J Titze","year":"2014","journal-title":"Curr Opin Nephrol Hypertens."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"1191-7","DOI":"10.1016\/j.kint.2017.11.021","article-title":"Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected by 23Na magnetic resonance imaging.","volume":"93","author":"C Kopp","year":"2018","journal-title":"Kidney Int."},{"key":"ref-47","doi-asserted-by":"publisher","first-page":"1086-93","DOI":"10.1016\/j.acra.2017.03.012","article-title":"3 Tesla 23Na Magnetic Resonance Imaging During Acute Kidney Injury.","volume":"24","author":"M Hammon","year":"2017","journal-title":"Acad Radiol."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"515-8","DOI":"10.1002\/mrm.26036","article-title":"Hyperpolarized 13C urea relaxation mechanism reveals renal changes in diabetic nephropathy.","volume":"75","author":"C Laustsen","year":"2016","journal-title":"Magn Reson 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Med."},{"key":"ref-52","doi-asserted-by":"publisher","first-page":"85-9","DOI":"10.1159\/000167563","article-title":"The importance of sample size in the interpretation of the renal biopsy.","volume":"8","author":"H Corwin","year":"1988","journal-title":"Am J Nephrol."},{"key":"ref-53","doi-asserted-by":"publisher","first-page":"251-64","DOI":"10.2310\/7290.2011.00045","article-title":"Molecular imaging of autoimmune diseases and inflammation.","volume":"11","author":"S Sargsyan","year":"2012","journal-title":"Mol Imaging."},{"key":"ref-54","doi-asserted-by":"publisher","first-page":"834-42","DOI":"10.1097\/RLI.0b013e31829d0414","article-title":"T2 relaxation time and apparent diffusion coefficient for noninvasive assessment of renal pathology after acute kidney injury in mice: Comparison with histopathology.","volume":"48","author":"K Hueper","year":"2013","journal-title":"Invest Radiol."},{"key":"ref-55","doi-asserted-by":"publisher","first-page":"44-50","DOI":"10.1007\/s00330-017-4943-4","article-title":"Assessment of acute kidney injury with T1 mapping MRI following solid organ transplantation.","volume":"28","author":"M Peperhove","year":"2018","journal-title":"Eur Radiol."},{"key":"ref-56","doi-asserted-by":"publisher","first-page":"67-81","DOI":"10.1016\/j.jcmg.2015.11.005","article-title":"T1 Mapping: Basic Techniques and Clinical Applications.","volume":"9","author":"A Taylor","year":"2016","journal-title":"JACC Cardiovasc Imaging."},{"key":"ref-57","doi-asserted-by":"publisher","first-page":"1066-74","DOI":"10.1016\/j.mri.2015.06.019","article-title":"Towards the identification of multi-parametric quantitative MRI biomarkers in lupus nephritis.","volume":"33","author":"S Rapacchi","year":"2015","journal-title":"Magn Reson Imaging."},{"key":"ref-58","doi-asserted-by":"publisher","first-page":"786-92","DOI":"10.1007\/s11307-015-0860-6","article-title":"Molecular Ultrasound Imaging of Tissue Inflammation Using an Animal Model of Acute Kidney Injury.","volume":"17","author":"K Hoyt","year":"2015","journal-title":"Mol Imaging Biol."},{"key":"ref-59","doi-asserted-by":"publisher","first-page":"1612-9","DOI":"10.1111\/ajt.13648","article-title":"Renal Contrast-Enhanced Sonography Findings in a Model of Acute Cellular Allograft Rejection.","volume":"16","author":"A Grabner","year":"2016","journal-title":"Am J Transplant."},{"key":"ref-60","doi-asserted-by":"publisher","first-page":"178-82","DOI":"10.1016\/j.clinimag.2008.03.001","article-title":"Evaluation of renal ischemia-reperfusion injury in rabbits using microbubbles targeted to activated neutrophils.","volume":"32","author":"X Jing","year":"2008","journal-title":"Clin Imaging."},{"key":"ref-61","doi-asserted-by":"publisher","first-page":"465-74","DOI":"10.1038\/ki.2008.496","article-title":"Ultrasmall superparamagnetic iron oxides (USPIOs): a future alternative magnetic resonance (MR) contrast agent for patients at risk for nephrogenic systemic fibrosis (NSF)?","volume":"75","author":"E Neuwelt","year":"2009","journal-title":"Kidney Int."},{"key":"ref-62","doi-asserted-by":"publisher","first-page":"819-26","DOI":"10.1148\/radiology.217.3.r00dc04819","article-title":"Nephrotoxic nephritis and obstructive nephropathy: evaluation with MR imaging enhanced with ultrasmall superparamagnetic iron oxide-preliminary findings in a rat model.","volume":"217","author":"O Hauger","year":"2000","journal-title":"Radiology."},{"key":"ref-63","doi-asserted-by":"publisher","first-page":"156-62","DOI":"10.1002\/(SICI)1522-2594(199901)41:1<156::AID-MRM22>3.0.CO;2-C","article-title":"MR imaging of intrarenal macrophage infiltration in an experimental model of nephrotic syndrome.","volume":"41","author":"O Hauger","year":"1999","journal-title":"Magn Reson Med."},{"key":"ref-64","doi-asserted-by":"publisher","first-page":"43-51","DOI":"10.1046\/j.1523-1755.2003.00048.x","article-title":"Detection of inflammation following renal ischemia by magnetic resonance imaging.","volume":"64","author":"S Jo","year":"2003","journal-title":"Kidney Int."},{"key":"ref-65","doi-asserted-by":"publisher","first-page":"2898-907","DOI":"10.1007\/s00330-007-0660-8","article-title":"USPIO-enhanced MR imaging of macrophage infiltration in native and transplanted kidneys: initial results in humans.","volume":"17","author":"O Hauger","year":"2007","journal-title":"Eur Radiol."},{"key":"ref-66","doi-asserted-by":"publisher","first-page":"517-26","DOI":"10.1148\/radiol.09091134","article-title":"Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in mice.","volume":"255","author":"N Serkova","year":"2010","journal-title":"Radiology."},{"key":"ref-67","doi-asserted-by":"publisher","first-page":"152-9","DOI":"10.1038\/ki.2011.332","article-title":"Detection of glomerular complement C3 fragments by magnetic resonance imaging in murine lupus nephritis.","volume":"81","author":"S Sargsyan","year":"2012","journal-title":"Kidney Int."},{"key":"ref-68","doi-asserted-by":"publisher","first-page":"36-45","DOI":"10.1006\/jmre.1998.1440","article-title":"Detection of proton chemical exchange between metabolites and water in biological tissues.","volume":"133","author":"V Guivel-Scharen","year":"1998","journal-title":"J Magn Reson."},{"key":"ref-69","doi-asserted-by":"publisher","first-page":"757-64","DOI":"10.1016\/j.kint.2017.04.015","article-title":"GlucoCEST magnetic resonance imaging in vivo may be diagnostic of acute renal allograft rejection.","volume":"92","author":"D Kentrup","year":"2017","journal-title":"Kidney Int."},{"key":"ref-70","doi-asserted-by":"publisher","first-page":"1831-7","DOI":"10.2967\/jnumed.117.193037","article-title":"Integrating MRI and Chemokine Receptor CXCR4-Targeted PET for Detection of Leukocyte Infiltration in Complicated Urinary Tract Infections After Kidney Transplantation.","volume":"58","author":"T Derlin","year":"2017","journal-title":"J Nucl Med."},{"key":"ref-71","doi-asserted-by":"publisher","first-page":"226-37","DOI":"10.1038\/nrneph.2014.14","article-title":"Potential approaches to reverse or repair renal fibrosis.","volume":"10","author":"D Tampe","year":"2014","journal-title":"Nat Rev Nephrol."},{"key":"ref-72","doi-asserted-by":"publisher","first-page":"1-17","DOI":"10.1016\/S0272-6386(12)80312-X","article-title":"Tubulointerstitial changes as a major determinant in the progression of renal damage.","volume":"20","author":"K Nath","year":"1992","journal-title":"Am J Kidney 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