{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:57Z","timestamp":1772168937243,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.163212.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000}}],"reference-count":11,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>In this datanote we present data from 31 iRBD (idiopathic Rapid eye movement (REM) sleep Behaviour Disorder) patients followed throughout three years to assess their eventual phenoconversion to Parkinson\u2019s disease and other established neurodegenerative conditions. iRBD is a prodromal condition of neurological pathologies such as Parkinson\u2019s disease. We evaluated transcription factor mRNA levels in CD4+ T cells as predictive biomarkers of phenoconversion in iRBD, showing that among the transcription factors mRNA levels analysed, STAT1, GATA3 and FOXP3 mRNA levels may be used to predict phenoconversion. In particular, we found that CD4+ T cells from converters had higher STAT1, and lower GATA3 and FOXP3 mRNA levels. According to ROC curve analysis STAT1 levels provided a good discrimination, GATA3 levels an excellent discrimination of future converters and not-converters, while discrimination provided by FOXP3 levels was acceptable.<\/ns3:p>","DOI":"10.12688\/f1000research.163212.2","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T10:00:08Z","timestamp":1759744808000},"page":"683","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["CD4+ T-cell transcription factors as early predictors of phenoconversion in idiopathic rapid eye movement sleep behaviour disorder"],"prefix":"10.12688","volume":"14","author":[{"given":"Monica","family":"Pinoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Terzaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1837-7810","authenticated-orcid":false,"given":"Franca","family":"Marino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-9468","authenticated-orcid":false,"given":"Cristoforo","family":"Comi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Versino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6978-7775","authenticated-orcid":false,"given":"Marco","family":"Cosentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"424-432","DOI":"10.1016\/S1474-4422(06)70441-0","article-title":"Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases.","volume":"5","author":"J Gagnon","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"57-69","DOI":"10.1016\/S1087-0792(97)90006-X","article-title":"REM sleep behavior disorder: clinical and physiopathological findings.","volume":"1","author":"E Sforza","year":"1997","journal-title":"Sleep Med. 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A practical method for grading the cognitive state of patients for the clinician.","volume":"12","author":"M Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1306-1312","DOI":"10.1002\/mds.20153","article-title":"Assessment of autonomic dysfunction in Parkinson\u2019s disease: the SCOPA-AUT.","volume":"19","author":"M Visser","year":"2004","journal-title":"Mov. Disord."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"56-62","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression.","volume":"23","author":"M Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. 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Haider, University of Technology, Baghdad, Baghdad, 28 Oct 2025, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/14-683\/v2#referee-response-420598","order":1,"name":"referee-response-420598","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Adawiya haider<\/b>; \n<i>Posted: 20 Oct 2025<\/i>; Thanks to all authors who response to all my comments. regards","URL":"https:\/\/f1000research.com\/articles\/14-683\/v2#article-response-14823","order":2,"name":"article-response-14823","label":"Article Comment","group":{"name":"article-comments","label":"Article Comments"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}