{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:57Z","timestamp":1772168937742,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.16606.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000}},{"DOI":"10.12688\/f1000research.16606.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000}}],"reference-count":13,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003971","name":"Islamic Development Bank","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:\u00a0<\/ns4:bold>\n                    Malaria still presents as a major health problem in Indonesia and specifically in East Kalimantan. One common sign found in malaria patient is thrombocytopenia, the mechanism of which is still unclear. Several studies have suggested some mechanisms, one of which is splenomegaly. This study aimed to discover the association between thrombocytopenia and splenomegaly of malaria patients in East Kalimantan.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:\u00a0<\/ns4:bold>\n                    This study was a descriptive retrospective study with clinical and laboratory data obtained from the medical records of malaria patients in four major public hospitals from January 2015 to July 2018. The association between thrombocytopenia with splenomegaly was analysed using Chi-Square test.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:\u00a0<\/ns4:bold>\n                    A total of 215 patients were included; 189 male (87.9%) and 26 female (12.1%). The etiologic agents found in these patients were\u00a0\n                    <ns4:italic>Plasmodium vivax\u00a0<\/ns4:italic>\n                    (43.2%),\u00a0\n                    <ns4:italic>Plasmodium falciparum\u00a0<\/ns4:italic>\n                    (42.8%), and mixed infection (\n                    <ns4:italic>Plasmodium falciparum\u00a0<\/ns4:italic>\n                    and\u00a0\n                    <ns4:italic>Plasmodium vivax<\/ns4:italic>\n                    ) (4.6%). The thrombocyte count was normal in 28 patients (13%) and decreased in 187 patients (87%). Among patients with thrombocytopenia, the percentage of mild, moderate and severe thrombocytopenia was 18.2%, 43.8% and 33%, respectively. Splenomegaly was found in only 11 patients (5.1%). We found no association between thrombocytopenia with splenomegaly (p=0.61).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:\u00a0<\/ns4:bold>\n                    We conclude that splenomegaly, which was a rare clinical finding of these malaria patients, was not associated with thrombocytopenia.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.16606.3","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T12:25:29Z","timestamp":1572351929000},"page":"1832","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of thrombocytopenia with splenomegaly in malaria patients in East Kalimantan: A cross-sectional, retrospective study"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6942-4819","authenticated-orcid":false,"given":"Loly R.D.","family":"Siagian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera M.","family":"Lumbantoruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurul","family":"Hasanah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fransiska A.","family":"Sihotang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carta","family":"Gunawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"ref-1","article-title":"Health Ministry of Indonesia","year":"2013"},{"key":"ref-2","article-title":"Annual Report East Kalimantan Provincial Health Office","year":"2013"},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"197-200","DOI":"10.4103\/1755-6783.116521","article-title":"Thrombocytopenia in Malaria and Its Correlation with Different Types of Malaria.","volume":"6","author":"M Gill","year":"2013","journal-title":"Ann Trop Med Public Health."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"012007","DOI":"10.1088\/1755-1315\/144\/1\/012007","article-title":"Thrombocyte counts in malaria patients at East Kalimantan.","volume":"144","author":"L Siagian","year":"2018","journal-title":"IOP Conf. Series: Earth and Environmental Science."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"343-35","DOI":"10.1111\/j.1462-5822.2011.01741.x","article-title":"The role of the spleen in malaria.","volume":"14","author":"H Del Portillo","year":"2012","journal-title":"Cell Microbiol."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"e63410","DOI":"10.1371\/journal.pone.0063410","article-title":"Thrombocytopenia in Plasmodium vivax malaria is related to platelets phagocytosis.","volume":"8","author":"H Coelho","year":"2013","journal-title":"PLoS One."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"2373-2378","DOI":"10.18203\/2320-6012.ijrms20161817","article-title":"A Study of Thrombocytopenia in Malaria and Its Prognostic Significance.","volume":"4","author":"M Arif","year":"2016","journal-title":"Int J Res Med Sci."},{"key":"ref-8","first-page":"145-7","article-title":"Thrombocytopenia in plasmodium falciparum malaria.","volume":"21","author":"S Ansari","year":"2009","journal-title":"J Ayub Med Coll Abbottabad."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s12916-015-0324-5","article-title":"The clinical implications of thrombocytopenia in adults with severe falciparum malaria: a retrospective analysis.","volume":"13","author":"J Hanson","year":"2015","journal-title":"BMC Med."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"116-121","DOI":"10.5455\/2320-6012.ijrms20150120","article-title":"Incidence, Severity, Prognostic Significance of Thrombocytopenia in Malaria.","volume":"3","author":"B Rao","year":"2015","journal-title":"Int J Res Med Sci."},{"key":"ref-11","first-page":"287-291","article-title":"Malaria and Hematological Changes.","volume":"24","author":"A Abro","year":"2008","journal-title":"Pak J Med Sci."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"58-61","DOI":"10.4103\/2229-5070.113914","article-title":"Study of thrombocytopenia in patients of malaria.","volume":"3","author":"N Gupta","year":"2013","journal-title":"Trop Parasitol."},{"key":"ref-13","article-title":"Dataset 1 in: Association of thrombocytopenia with splenomegaly in malaria patients in East Kalimantan: A cross-sectional, retrospective study.","author":"L Siagian","year":"2018","journal-title":"F1000Research."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/7-1832\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/7-1832\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/7-1832\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T06:35:09Z","timestamp":1572417309000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/7-1832\/v3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":13,"URL":"https:\/\/doi.org\/10.12688\/f1000research.16606.3","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.23205.r55902","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.23205.r55902","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/7-1832\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.22114.r52475, Jontari Hutagalung, Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health (Indonesia), Jakarta, Indonesia, 27 Aug 2019, version 2, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/7-1832\/v2#referee-response-52475","order":0,"name":"referee-response-52475","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.23205.r55902, Brendan J. McMorran, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia, 30 Oct 2019, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/7-1832\/v3#referee-response-55902","order":1,"name":"referee-response-55902","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The Islamic Development Bank funded this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}