{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:10:58Z","timestamp":1789096258589,"version":"build-2803163510"},"reference-count":25,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Radiation therapy (RT) for central nervous system (CNS) malignancies can result in neurocognitive decline, affecting quality of life. While hippocampal-sparing approaches are well documented, limited data exist on the impact of radiation dose to other cognitive structures. This prospective study evaluates domain-specific cognitive changes following RT and explores correlations with radiation dose to key brain regions. Methodology Twenty-five patients with primary CNS tumours undergoing focal radiotherapy, with or without concurrent chemotherapy, were enrolled. Neurocognitive function was assessed using the Addenbrooke\u2019s Cognitive Examination III (ACE-III) tool, pre- and six months post-treatment. Radiation dose-volume histogram (DVH) data were analyzed for structures including the hippocampus, amygdala, cerebellum, and corpus callosum. Patients were stratified based on ACE-III score decline (\u22653 points vs. &lt;3 points), and dose-response correlations were examined. Results A statistically significant decline in mean ACE-III scores was observed post-treatment (pre: 89.48 \u00b1 6.84 vs. post: 87.91 \u00b1 6.29, p = 0.007). Attention, language, and fluency were the most affected domains. Patients with cognitive decline received higher radiation doses to all examined structures, with the corpus callosum showing the strongest association (mean dose in decline group: 35.91 Gy vs. 30.70 Gy; p = 0.440). However, no dose-response relationship reached statistical significance. Conclusion This study highlights early, domain-specific neurocognitive decline following focal RT for CNS tumours, with attention and language being most vulnerable. Corpus callosum dose emerged as a key correlate. These findings suggest the need to broaden neuroprotection strategies beyond the hippocampus and emphasize the value of incorporating routine neurocognitive assessment.<\/ns3:p>","DOI":"10.12688\/f1000research.166763.1","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T15:15:08Z","timestamp":1757517308000},"page":"895","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal Assessment of Neurocognitive Outcomes and Correlation with Limbic System Radiation Doses in Patients Undergoing Radiotherapy for Central Nervous System Tumours: A preliminary report"],"prefix":"10.12688","volume":"14","author":[{"given":"Prerana","family":"Baruah","sequence":"first","affiliation":[{"name":"Manipal Department of Radiation Oncology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, 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Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Simon","sequence":"additional","affiliation":[{"name":"Manipal Department of Radiation Oncology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muralidhar","family":"Pai","sequence":"additional","affiliation":[{"name":"Manipal Department of Neurosurgery, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayur","family":"Kamath","sequence":"additional","affiliation":[{"name":"Manipal Department of Neurosurgery, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Shetty","sequence":"additional","affiliation":[{"name":"Manipal Department of Neurosurgery, Kasturba Medical College Mangalore, 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Bergo","year":"2019","journal-title":"Eur. J. Cancer Care (Engl)."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"541-549","DOI":"10.1007\/s11060-010-0417-0","article-title":"Cognitive effects of tumour and surgical treatment in glioma patients.","volume":"103","author":"A Talacchi","year":"2011","journal-title":"J. Neuro-Oncol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1677-1685","DOI":"10.1093\/neuonc\/noaa076","article-title":"Hippocampal radiotherapy dose-constraints for predicting long-term neurocognitive outcomes: Mature data from a prospective trial in young patients with brain tumors.","volume":"22","author":"J Goda","year":"2020","journal-title":"Neuro-Oncology."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"634-640","DOI":"10.1097\/COC.0000000000000158","article-title":"Neurocognitive Deficits After Radiation Therapy for Brain Malignancies.","volume":"38","author":"S Saad","year":"2015","journal-title":"Am. J. Clin. 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Oncol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"35-42","DOI":"10.1016\/j.radonc.2015.12.003","article-title":"ESTRO-ACROP guideline \u201ctarget delineation of glioblastomas.\u201d","volume":"118","author":"M Niyazi","year":"2016 Jan 1 cited 2025 Jun 1","journal-title":"Radiother. Oncol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"259-265","DOI":"10.1016\/j.radonc.2021.05.013","article-title":"Update of the EPTN atlas for CT- and MR-based contouring in Neuro-Oncology.","volume":"160","author":"D Eekers","year":"2021 Jul 1 cited 2025 Jun 1","journal-title":"Radiother. Oncol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"99-105","DOI":"10.1016\/j.ctro.2022.07.003","article-title":"Time- and dose-dependent volume decreases in subcortical grey matter structures of glioma patients after radio (chemo)therapy.","volume":"36","author":"F Raschke","year":"2022 Sep 1 cited 2025 Jun 1","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1019-1029","DOI":"10.1200\/JCO.19.02767","article-title":"Hippocampal avoidance during whole-brain radiotherapy plus memantine for patients with brain metastases: Phase III trial NRG oncology CC001.","volume":"38","author":"P Brown","year":"2020 Apr 1 cited 2025 Jun 1","journal-title":"J. Clin. Oncol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1234-1242","DOI":"10.1016\/j.ijrobp.2018.04.037","article-title":"Association of Neuronal Injury in the Genu and Body of Corpus Callosum Following Cranial Irradiation in Children with Impaired Cognitive Control: A Prospective Study.","volume":"101","author":"K Redmond","year":"2018 Aug 1 cited 2025 Jun 1","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"234-240","DOI":"10.1016\/j.radonc.2016.06.021","article-title":"Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors.","volume":"120","author":"C Chapman","year":"2016 Aug 1 cited 2025 Jun 1","journal-title":"Radiother. Oncol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3810-3816","DOI":"10.1200\/JCO.2014.57.2909","article-title":"Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): A phase II multi-institutional trial.","volume":"32","author":"V Gondi","year":"2014 Dec 1 cited 2025 Jun 1","journal-title":"J. Clin. Oncol."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"489-501","DOI":"10.1016\/j.neuroimage.2008.08.039","article-title":"Functional topography in the human cerebellum: A meta-analysis of neuroimaging studies.","volume":"44","author":"C Stoodley","year":"2009 Jan 15 cited 2025 Jun 1","journal-title":"Neuroimage."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1218-1228","DOI":"10.1016\/j.ijrobp.2020.07.032","article-title":"Microstructural injury to left-sided perisylvian white matter predicts language decline after brain radiotherapy.","volume":"108","author":"M Tibbs","year":"2020 Dec 1 cited 2025 Jun 1","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1559-1561","DOI":"10.1093\/neuonc\/noaa208","article-title":"Impact of radiotherapy dosimetric parameters on neurocognitive function in brain tumor patients.","volume":"22","author":"R Kotecha","year":"2020 Nov 1 cited 2025 Jun 1","journal-title":"Neuro-Oncology."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e3-e9","DOI":"10.1016\/j.prro.2024.08.005","article-title":"Memory Tract Sparing Using Diffusion Tensor Imaging in Radiation Planning of Primary Brain Tumors.","volume":"15","author":"O Haisraely","year":"2024 Jan 1 cited 2025 Jun 1","journal-title":"Pract. Radiat. 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