{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:27:41Z","timestamp":1781886461994,"version":"3.54.5"},"reference-count":42,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fred and Suzanne Biesecker Pediatric Liver Center"},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["R56 DK119290"],"award-info":[{"award-number":["R56 DK119290"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Biliary atresia (BA) is a neonatal liver disease characterized by progressive obstruction and fibrosis of the extrahepatic biliary tree as well as fibrosis and inflammation of the liver parenchyma. Recent studies found that infants who will go on to develop BA have elevated direct bilirubin levels in the first few days of life, suggesting that the disease starts <ns4:italic>in utero<\/ns4:italic>. The etiology and pathogenesis of BA, however, remain unknown. Here, we discuss recent studies examining potential pathogenetic mechanisms of BA, including genetic susceptibility, involvement of the immune system, and environmental insults such as viruses and toxins, although it is possible that there is not a single etiological agent but rather a large group of injurious insults that result in a final common pathway of extrahepatic bile duct obstruction and liver fibrosis. The management and diagnosis of BA have not advanced significantly in the past decade, but given recent advances in understanding the timing and potential pathogenesis of BA, we are hopeful that the next decade will bring early diagnostics and novel therapeutics.<\/ns4:p>","DOI":"10.12688\/f1000research.16732.1","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T05:20:27Z","timestamp":1551072027000},"page":"218","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Recent advances in understanding biliary atresia"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-4037","authenticated-orcid":false,"given":"Andrew","family":"Wehrman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orith","family":"Waisbourd-Zinman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca G","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2019,2,25]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"211-7","DOI":"10.1016\/j.jpeds.2015.11.058","article-title":"Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia.","volume":"170","author":"B Shneider","year":"2016","journal-title":"J 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.18289.r44674, Tatsuo Kuroda, Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, Japan, 25 Feb 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-218\/v1#referee-response-44674","order":0,"name":"referee-response-44674","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.18289.r44673, Jan B F Hulscher, Department of Surgery, Division of Pediatric Surgery, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands, 25 Feb 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-218\/v1#referee-response-44673","order":1,"name":"referee-response-44673","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.18289.r44675, Mohamed Rela, Dr. Rela Institute & Medical Centre, National Foundation for Liver Research, Chennai, India, 25 Feb 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-218\/v1#referee-response-44675","order":2,"name":"referee-response-44675","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by the Fred and Suzanne Biesecker Pediatric Liver Center and the National Institute of Diabetes and Digestive and Kidney Diseases (R56 DK119290). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}