{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:09:03Z","timestamp":1791353343567,"version":"4.3.1"},"reference-count":29,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, affecting 5-20% of women worldwide. Hyperandrogenism, as the primary characteristic of PCOS, is not always present in every patient. The hyperandrogenic phenotype of PCOS patients is influenced by both hormonal and metabolic dysfunctions. Therefore, this study aims to determine the correlation between hormone profile, lipid profile, and clinical profile with free testosterone index in subjects with PCOS.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    This prospective cross-sectional study was conducted in the Dr. Cipto Mangunkusumo General Hospital between July 2014 and December 2016. The study involved 76 women with PCOS, who were classified into 2 subgroups: 39 subjects in the hyperandrogenism group and 37 subjects in the non-hyperandrogenism group. Each subject underwent physical examination, blood sample collection, and USG examination. Bivariate analysis was done using independent t-tests and Mann Whitney U-tests, while multivariate analysis was done using logistic regression.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    Triglyceride and testosterone level showed weak (r = 0.232, p = 0.044) and moderate (r = 0.460, p \u00a1 0.001) positive correlation with FTI, while SHBG level showed moderate negative correlation (r = -0.483, p \u00a1 0.001). Triglyceride was also found to be determinant of hyperandrogenism condition in PCOS patient (OR 0.02, 95% CI 0.00\u20130.04, p = 0.013). However, there was no significant difference observed between FGS and hyperandrogenism (p = 0.43).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    Triglycerides, testosterone, and SHBG were associated with hyperandrogenism in PCOS patients, while FGS showed no such association.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.16815.1","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T11:56:27Z","timestamp":1548244587000},"page":"94","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7424-679X","authenticated-orcid":false,"given":"Andon","family":"Hestiantoro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Putri Deva","family":"Karimah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Shadrina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budi","family":"Wiweko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-3931","authenticated-orcid":false,"given":"R.","family":"Muharam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brilliant Putri Kusuma","family":"Astuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"1-13","DOI":"10.2147\/CLEP.S37559","article-title":"Epidemiology, diagnosis, and management of polycystic ovary syndrome.","volume":"6","author":"S Sirmans","year":"2013","journal-title":"Clin Epidemiol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12958-016-0173-x","article-title":"Genetic, hormonal and metabolic aspects of PCOS: an update.","volume":"14","author":"V De Leo","year":"2016","journal-title":"Reprod Biol Endocrinol."},{"key":"ref-3","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7624932","article-title":"Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology.","volume":"2018","author":"R Dadachanji","year":"2018","journal-title":"Genet Res 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Hestiantoro","year":"2019","journal-title":"F1000Research."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/8-94\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-94\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-94\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T03:00:33Z","timestamp":1593572433000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/8-94\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,23]]},"references-count":29,"URL":"https:\/\/doi.org\/10.12688\/f1000research.16815.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.18382.r44622","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.18382.r43535","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.18382.r43535","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.18382.r44622","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,23]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/8-94\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.18382.r43535, Xue Lian Li, Dan-Feng Du, Department of Gynaecology,  OB\/GYN Hospital, Fudan University, Shanghai, China, 05 Feb 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-94\/v1#referee-response-43535","order":0,"name":"referee-response-43535","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Andon Hestiantoro<\/b>; \n<i>Posted: 13 Mar 2019<\/i>; Dear Dr. Xue Lian Li,We are very sorry for the late reply. Thank you for your constructive comments and suggestions about our study.I admit that one of the limitations of this study is the small sample size, which makes the generalisation of these results to entire PCOS populations difficult. Therefore, future studies with greater sample size and longer observation durations should be established.As you mentioned previously in your reviews, I did not differentiate and classify the phenotype of PCOS in this study. Distinguishing PCOS phenotypes is an important aspect in the diagnosis and treatment of this syndromes, for different phenotypes might present in different manifestations and required different approach. This might be the reason why some of the findings in our study showed different or even contradictory results to another studies.Once again, thank you for your kind reviews. I look forward to be working and collaborating with you in some future researches.&nbsp;Cordially,&nbsp;Andon Hestiantoro","URL":"https:\/\/f1000research.com\/articles\/8-94\/v1#referee-comment-4479","order":1,"name":"referee-comment-4479","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.18382.r44622, Zheying Min, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Key Laboratory of Assisted Reproduction, Ministry of Education, Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China, 07 Mar 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-94\/v1#referee-response-44622","order":2,"name":"referee-response-44622","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Andon Hestiantoro<\/b>; \n<i>Posted: 13 Mar 2019<\/i>; Dear Dr. Zheying Min,Thank you for your constructive comments and suggestions about our study. Please find below a point-by-point response to your reviews.&nbsp;\n<b>The average BMI of all PCOS patients were more than 25 (27.6). Could obesity influence the statistical&nbsp;analysis of the hormone?<\/b>There is a possibility that obesity affect the lipid and hormonal profiles of our subjects. Pathophysiologically speaking, obesity is closely related with dyslipidemia as well as insulin resistance, therefore statistical analysis with body mass index adjustment should be performed to independently study the association between PCOS and hormone concentrations.&nbsp;\n<b>There are some evident errors in Tables. For example, In Table 1, is the average value of the body weight 0.6?<\/b>I am sorry for my carelessness and thank you for alerting me about this mistakes. We will revise it soon.&nbsp;\n<b>The manuscript must be edited again for typo errors. In the discussion, \u201cThere are marked increases in GnRH and LH secretion, along with relative deficit in FSH secretion\u2026\u2026\u201d I think it should change deficit&nbsp;to deficiency.<\/b>I am sorry again for my carelessness and we also will revise it soon.\n<b>There are too many references in the discussion part, which&nbsp;should be moved to the introduction part. Because it only includes 9 references in the introduction.<\/b>We will re-arrange it and see if any of these references could be moved to introduction part.Once again, thank you for your kind reviews. I look forward to be working and collaborating with you in some future researches.&nbsp;Cordially,&nbsp;Andon Hestiantoro","URL":"https:\/\/f1000research.com\/articles\/8-94\/v1#referee-comment-4480","order":3,"name":"referee-comment-4480","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}