{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:32:02Z","timestamp":1777984322155,"version":"3.51.4"},"reference-count":14,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns7:p>Abstract* Background Chronic venous insufficiency (CVI) is a prevalent and underdiagnosed disease affecting over 25 million adults worldwide. Endovenous laser ablation (EVLA) remains the gold standard for great saphenous vein (GSV) insufficiency. However, conventional EVLA performed 1\u20132 cm distal to the saphenofemoral junction (SFJ) often leaves residual tributaries, increasing the risk of recurrence. Zone-zero laser crossectomy, defined as laser crossectomy performed exactly at the 0 cm zone of the SFJ (zone-zero ablation), had been proposed as a minimally invasive alternative technique to eliminate residual stumps and reduce varicose vein recurrence. This case series of zone-zero laser crossectomy aims to share our experiences and outcomes amongst 57 patients in our center. Methods A total of 57 consecutive patients with symptomatic GSV insufficiency (CEAP C2\u2013C6) underwent EVLA using a 1470 nm radial double-ring swift laser with zone-zero ablation at the SFJ. Procedural parameters, complications, and postoperative outcomes were recorded. Patients were followed at 7 days, 4, 8, and 12 weeks with physical and duplex ultrasound examinations. Results The mean age was 61.6 years. No recanalization was observed during the 3-month follow-up, with duplex ultrasound confirming complete obliteration of treated GSVs. Postoperative complications included leg pain in 3 cases (5.26%), EHIT grade I\u2013II in 1 case (1.75%), hyperpigmentation in 1 case (1.75%), and paresthesia in 1 case (1.75%). All complications were mild and managed conservatively. Conclusions Zone-zero laser crossectomy is a safe and effective modification of EVLA for GSV insufficiency, demonstrating high obliteration rates and low complication rates. Larger cohorts with longer follow-up are needed to confirm durability.<\/ns7:p>","DOI":"10.12688\/f1000research.170645.1","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:24:08Z","timestamp":1768973048000},"page":"96","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful single-center experiences of laser crossectomy in zone zero in Endovenous Laser Ablation (EVLA) for chronic venous insufficiency - a case series"],"prefix":"10.12688","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6363-9010","authenticated-orcid":false,"given":"Taofan","family":"Taofan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2848-0566","authenticated-orcid":false,"given":"Suko","family":"Ardiarto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-0390","authenticated-orcid":false,"given":"Suci","family":"Indriani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth Grace","family":"Aurora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelin","family":"Dhivi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aris","family":"Munandar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vekky","family":"Sariowan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Mulia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadhil","family":"Pratama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rido Jati","family":"Kuncara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyun","family":"Pamungkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4789-0747","authenticated-orcid":false,"given":"Kelvin","family":"Kohar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8001-9054","authenticated-orcid":false,"given":"Matthew","family":"Sebastian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Rachman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Ferdinand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6366-833X","authenticated-orcid":false,"given":"Junichi","family":"Utoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Vuylsteke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Weiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5360-2759","authenticated-orcid":false,"given":"Iwan","family":"Dakota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5325-4125","authenticated-orcid":false,"given":"Bambang","family":"Widyantoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"184-267","DOI":"10.1016\/j.ejvs.2021.12.024","article-title":"Editor\u2019s Choice \u2013 European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs.","volume":"63","author":"M Maeseneer","year":"2022 Feb 1","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"101670","DOI":"10.1016\/j.jvsv.2023.08.011","article-title":"The 2023 Society for Vascular Surgery, American Venous Forum, and American Vein and Lymphatic Society clinical practice guidelines for the management of varicose veins of the lower extremities. Part II: Endorsed by the Society of Interventional Radiology and the Society for Vascular Medicine.","volume":"12","author":"P Gloviczki","year":"2024 Jan 1 cited 2025 Sep 2","journal-title":"J. Vasc. Surg. Venous Lymphat. Disord."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"767-773","DOI":"10.4103\/ejs.ejs_117_23","article-title":"Closed randomized comparative study of great saphenous vein crossectomy laser ablation versus standard laser technique to minimize recurrence in the treatment of primary varicose veins.","volume":"42","author":"S Nagib","year":"2023 Sep","journal-title":"Egypt J. Surg."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"822-829","DOI":"10.1016\/j.jvs.2007.10.060","article-title":"High ligation combined with stripping and endovenous laser ablation of the great saphenous vein: early results of a randomized controlled study.","volume":"47","author":"M Kalteis","year":"2008 Apr","journal-title":"J. Vasc. Surg."},{"key":"ref5","first-page":"7843-7848","article-title":"Comparison of high ligation and stripping of the great saphenous vein combined with foam sclerotherapy versus conventional surgery for the treatment of superficial venous varicosities of the lower extremity.","volume":"8","author":"Z Zhao","year":"2015 May 15","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"101842","DOI":"10.1016\/j.jvsv.2024.101842","article-title":"Endovenous radiofrequency ablation vs laser ablation in patients with lower extremity varicose veins: A meta-analysis.","volume":"12","author":"W Jiang","year":"2024 Sep 1","journal-title":"J. Vasc. Surg. Venous Lymphat. Disord."},{"key":"ref7","article-title":"Flush Endovenous Laser Ablation (fEVLA) in the Treatment of Lower Limb Venous Insufficiency a Systematic Review and Meta-Analysis - PubMed.","year":"cited 2025 Sep 2"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1744-1750","DOI":"10.1016\/j.avsg.2014.05.005","article-title":"The incidence and outcome of endothermal heat-induced thrombosis after endovenous laser ablation.","volume":"28","author":"K Kane","year":"2014 Oct","journal-title":"Ann. Vasc. Surg."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"S43-S48","DOI":"10.34172\/jlms.2020.S7","article-title":"Comparing the Success Rate and Side Effects of Endovenous Laser Ablation and Radiofrequency Ablation to Treat Varicose Veins in the Lower Limbs: A Randomized Clinical Trial.","volume":"11","author":"A Mohammadi Tofigh","year":"2020","journal-title":"J. Lasers Med. Sci."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"400-405","DOI":"10.1016\/j.ejvs.2010.11.029","article-title":"Does Puncture Site Affect the Rate of Nerve Injuries Following Endovenous Laser Ablation of the Small Saphenous Veins?","volume":"41","author":"S Doganci","year":"2011 Mar","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"484-485","DOI":"10.1177\/02683555231183780","article-title":"Prevention of saphenous nerve injury after below-knee laser ablation of incompetent great saphenous veins: A trial of two-step ablation and an early result.","volume":"38","author":"J Utoh","year":"2023 Aug 1","journal-title":"Phlebology."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.30193801","article-title":"Figure 1 - Bar Graph of Cases of CVI Based on CEAP Classification. Figshare Digital Repository. CC BY 4.0 [Licence].","author":"M Sebastian","year":"2025"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.30029992","article-title":"Laser Crossectomy Supplementary Data for F1000. Figshare Digital Repository. 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