{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:25:24Z","timestamp":1787023524577,"version":"build-2736575974"},"reference-count":13,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns5:p>\n                    Background and aims Infectious aneurysm is an aneurysm of the arteries originating from endogenous bacteraemia due to bacterial or fungal origin. The major vessels involved are femoral, aorta, then intracranial visceral arteries and pulmonary arteries. These aneurysms are identified by their fusiform shape, multiple, distal location involving the entire wall of the vessel and changing morphology on repeat imaging studies. The study aims to discuss the clinical presentation &amp; management of post infectious aneurysms. Methods This is a retrospective study of 11 case series of postinfectious aneurysms over a period of 10 years admitted at a tertiary care hospital. The detailed clinical data that included the clinical presentation, diagnostic and treatment was studied from the hospital medical records department and laboratory information system. Results Among the 11 patients diagnosed with aneurysms, 4 presented with intracranial, 4 with intra pulmonary and 3 with intra-abdominal aortic aneurysms involvement. Source was either of bacterial cause such as\n                    <ns5:italic>E.coli, Streptococcus gallolyticus, Salmonella<\/ns5:italic>\n                    Typhi,\n                    <ns5:italic>M. tuberculosis, Klebsiella pneumoniae<\/ns5:italic>\n                    , Methicillin Resistant\n                    <ns5:italic>S. aureus, S. hominis<\/ns5:italic>\n                    or fungal origin being\n                    <ns5:italic>Aspergillus spp.<\/ns5:italic>\n                    All of them had elevated C-reactive protein level, ESR and confirmed by positive cultures or Xpert Tb. Management of mycotic aneurysm includes imaging studies along with laboratory workup, endovascular intervention with intravenous antibiotics, or a combination of these. Conclusion High index of suspicion in patients presenting with fever, elevated C-reactive protein, ESR, total counts with sudden development of atypical aneurysms requires timely blood culture pre and post procedure. Definitive surgical\/endovascular under antibiotic coverage at the earliest is a prerequisite in the management to prevent re-rupture.\n                  <\/ns5:p>","DOI":"10.12688\/f1000research.171966.1","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T15:55:08Z","timestamp":1764777308000},"page":"1356","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring infectious aneurysms through a series of cases in a tertiary care unit in South India"],"prefix":"10.12688","volume":"14","author":[{"given":"Keerthiraj","family":"B","sequence":"first","affiliation":[{"name":"Kasturba Medical College Mangalore Manipal Manipal Academy of Higher Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0471-7351","authenticated-orcid":false,"given":"Bergin","family":"C","sequence":"additional","affiliation":[{"name":"Kasturba Medical College Mangalore Manipal Manipal Academy of Higher Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0717-783X","authenticated-orcid":false,"given":"Pooja","family":"Rao","sequence":"additional","affiliation":[{"name":"Kasturba Medical College Mangalore Manipal Manipal Academy of Higher Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udayalaxmi","family":"Jeppu","sequence":"additional","affiliation":[{"name":"Kasturba Medical College Mangalore Manipal Manipal Academy of Higher Education"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"353-356","DOI":"10.1136\/neurintsurg-2013-010755","article-title":"Onyx embolization of infectious intracranial aneurysms.","volume":"6","author":"R Grandhi","year":"2014","journal-title":"J. Neurointerv. Surg."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"ofae121","DOI":"10.1093\/ofid\/ofae121","article-title":"Epidemiology and Risk Factors of Mycotic Aneurysm in Patients with Infective Endocarditis and the Impact of its Rupture in Outcomes. Analysis of a National Prospective Cohort.","volume":"11","author":"J Calder\u00f3n-Parra","year":"2024 Mar 13","journal-title":"Open Forum Infect. Dis."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"467-470","DOI":"10.1136\/bmj.1.1262.467","article-title":"The gulstonian lectures, on malignant endocarditis.","volume":"1","author":"W Osler","year":"1885","journal-title":"Br. Med. J."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"S61-S70","DOI":"10.21037\/cdt.2017.09.03","article-title":"Inflammatory and infectious aortic diseases.","volume":"8","author":"A Deipolyi","year":"2018","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e412-e460","DOI":"10.1161\/CIR.0000000000000457","article-title":"Vascular Graft Infections, Mycotic Aneurysms, and Endovascular Infections: a scientific statement from the American Heart Association.","volume":"134","author":"W Wilson","year":"2016","journal-title":"Circulation."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"344-350","DOI":"10.2176\/nmc.oa.2019-0051","article-title":"Treatment Strategies for Infectious Intracranial Aneurysms: Report of Three Cases and Review of the Literature.","volume":"59","author":"K Ando","year":"2019 Sep 15","journal-title":"Neurol. Med. Chir. (Tokyo)."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1-3","DOI":"10.1136\/bcr-2019-233461","article-title":"Mycotic abdominal aortic aneurysm complicated by infective spondylitis due to Pseudomonas aeruginosa.","volume":"13","author":"R Dsouza","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref8","first-page":"e31010","article-title":"Mycotic Thoracic Aortic Aneurysm: Epidemiology, Pathophysiology, Diagnosis, and Management.","volume":"14","author":"L Raavi","journal-title":"Cureus."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"708-716","DOI":"10.1136\/neurintsurg-2017-013603","article-title":"Infectious intracranial aneurysms: a systematic review of epidemiology, management, and outcomes.","volume":"10","author":"A Alawieh","year":"2018","journal-title":"J. Neurointerv. Surg."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e6864","DOI":"10.1590\/1414-431x20186864","article-title":"Mycotic aneurysm due to Salmonella species: clinical experiences and review of the literature.","volume":"51","author":"Y Guo","year":"2018","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"861-867","DOI":"10.1067\/mva.2001.111977","article-title":"Ruptured mycotic thoracoabdominal aortic aneurysms: A report of three cases and a systematic review.","volume":"33","author":"C Cin\u00e0","year":"2001 Apr 1","journal-title":"J. Vasc. Surg."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"290-298","DOI":"10.1089\/sur.2013.011","article-title":"Clinical, Microbiologic, and Outcome Analysis of Mycotic Aortic Aneurysm: The Role of Endovascular Repair.","volume":"15","author":"Y Huang","year":"2014 Jun 1","journal-title":"Surg. Infect."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"29-35","DOI":"10.3400\/avd.oa.16-00117","article-title":"Surgical Management of Mycotic Aortic Aneurysms.","volume":"10","author":"C Aoki","year":"2017 Mar 24","journal-title":"Ann. Vasc. Dis."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/14-1356\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/14-1356\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/14-1356\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:44:10Z","timestamp":1787021050000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/14-1356\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":13,"URL":"https:\/\/doi.org\/10.12688\/f1000research.171966.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.189639.r497554","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.189639.r439175","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.189639.r497554","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.189639.r439175","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/14-1356\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.189639.r439175, Richa Sinha, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 30 Dec 2025, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/14-1356\/v1#referee-response-439175","order":0,"name":"referee-response-439175","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.189639.r497554, Rama Shankar Rath, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 18 Aug 2026, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/14-1356\/v1#referee-response-497554","order":1,"name":"referee-response-497554","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Ramashankar Rath<\/b>; \n<i>Posted: 23 Jul 2026<\/i>; Nicely written manuscript depicting a 11 cases.","URL":"https:\/\/f1000research.com\/articles\/14-1356\/v1#article-response-16739","order":2,"name":"article-response-16739","label":"Article Comment","group":{"name":"article-comments","label":"Article Comments"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}