{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:18:44Z","timestamp":1788023924685,"version":"build-2784847793"},"update-to":[{"DOI":"10.12688\/f1000research.172834.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000}},{"DOI":"10.12688\/f1000research.172834.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000}},{"DOI":"10.12688\/f1000research.172834.3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000}}],"reference-count":26,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009509","name":"Kementerian Riset Teknologi Dan Pendidikan Tinggi Republik Indonesia","doi-asserted-by":"publisher","award":["0419\/C3\/DT.05.00\/2025"],"award-info":[{"award-number":["0419\/C3\/DT.05.00\/2025"]}],"id":[{"id":"10.13039\/501100009509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Diabetic neuropathy is one of the complications of diabetes that occurs due to poor glycemic control. Brain-derived neurotrophic factor (BDNF) levels can increase when patients are first diagnosed with type 2 diabetes mellitus and can change in response to glycemic control conditions throughout the course of the disease. However, the correlation between glycemic control and BDNF remains unclear. The objective of this study was to investigate whether glycemic control can predict the BDNF levels in patients with diabetic neuropathy, based on diabetic duration. Methods A cross-sectional study was conducted on 8 patients with diabetic neuropathy who were treated at a clinic in Central Java. We use glycated hemoglobin (HbA1c) levels as a parameter of glycemic control, which were measured according to the National Glycohemoglobin Standardization Program. BDNF serum levels were evaluated using the Enzyme-Linked Immunosorbent Assay (ELISA) method in the laboratory. Analysis was performed using ANCOVA tests. Results Together, HbA1c levels, diabetic duration, and interactions between diabetic duration and HbA1c explained 9.9% of variability in BDNF levels (p=0.046). However, HbA1c levels explained 8.1% of the variability in BDNF levels (p = 0.011), with only minor contributions from diabetic duration and interaction them. Conclusions The HbA1c levels significantly explained the variability in BDNF levels in patients with diabetic neuropathy regardless of diabetic duration.<\/ns3:p>","DOI":"10.12688\/f1000research.172834.4","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:14:06Z","timestamp":1781241246000},"page":"1312","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycemic control predicts the Brain-derived neurotrophic factor levels in diabetic neuropathy patients with a diabetic duration of at least 5 years: A cross-sectional study"],"prefix":"10.12688","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8867-8339","authenticated-orcid":false,"given":"Maria","family":"Suryani","sequence":"first","affiliation":[{"name":"Nursing Semarang Central Java Sekolah Tinggi Ilmu Kesehatan Elisabeth Semarang"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Agustina","family":"Ermi Tri Sulistiyowati","sequence":"additional","affiliation":[{"name":"Nursing Semarang Central Java Sekolah Tinggi Ilmu Kesehatan Elisabeth Semarang"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3914-375X","authenticated-orcid":false,"given":"Medina","family":"Sianturi","sequence":"additional","affiliation":[{"name":"Nursing Semarang Central Java Sekolah Tinggi Ilmu Kesehatan Elisabeth Semarang"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"17-31","DOI":"10.1038\/s41582-024-01041-y","article-title":"The global and regional burden of diabetic peripheral neuropathy.","volume":"21","author":"M Savelieff","year":"2025","journal-title":"Nat. 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The revised version of the manuscript incorporates the corrections suggested by the reviewer. We still use predictor term according to new statistical analysis. We have used the updated references according to our topic.","URL":"https:\/\/f1000research.com\/articles\/14-1312\/v4#referee-comment-15641","order":1,"name":"referee-comment-15641","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.203067.r492257, Eric Siegel, University of Arkansas for Medical Sciences, Little Rock, AR, 12 Jun 2026, version 4, indexed","URL":"https:\/\/f1000research.com\/articles\/14-1312\/v4#referee-response-492257","order":2,"name":"referee-response-492257","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study was funded by the Kemendiktisaintek, Indonesia grant 0419\/C3\/DT.05.00\/2025. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}