{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:12Z","timestamp":1772168892237,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.17660.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000}}],"reference-count":21,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kobe University Hospital"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    The best method of antimicrobial prophylaxis administration for surgical site infection (SSI) in transurethral holmium laser resection and enucleation of the prostate (HoLEP)\/bipolar transurethral enucleation (TUEB) remains controversial. The purpose of this study is to compare one-day and two-day cefazolin in a randomized 2\n                    <ns4:sup>nd<\/ns4:sup>\n                    -phase study to help establish a protocol with a 95% confidence interval (CI) for SSI prevention.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    Patients undergoing HoLEP\/TUEB for benign prostate hyperplasia without preoperative pyuria will be enrolled and randomized to receive prophylactic antibiotic administration for HoLEP\/TUEB in two groups, 1-day (single dose) cefazolin and 2-day cefazolin. The primary endpoint is the occurrence rate of postoperative urinary tract infection or urogenital infection within 30 days after HoLEP\/TUEB with a statistical 95% CI in comparison between those groups. Secondary outcomes include the kind of infectious disease and evidence of diagnosis, day of diagnosis of infectious disease, performance of urine or blood culture, detection of bacteria, treatments, duration of treatments, AEs other than surgical site infection, and drug-induced AEs.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Discussion:<\/ns4:bold>\n                    The results of this study will provide evidence for defining the optimal duration of cefazolin prophylactic antibiotic administration for SSI.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Trial registration:<\/ns4:bold>\n                    This study was registered in the University Hospital Medical Information Network-Clinical Trial Registry (\n                    <ns4:ext-link xmlns:ns3=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" ns3:href=\"https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr_e\/ctr_view.cgi?recptno=R000032025\">UMIN000027955<\/ns4:ext-link>\n                    ) based on recommendations from the International Committee of Medical Journal Editors (ICMJE) on July 1\n                    <ns4:sup>st<\/ns4:sup>\n                    2017.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.17660.2","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T11:17:27Z","timestamp":1557400647000},"page":"161","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Protocol for a comparison study of 1-day (single dose) versus 2-day prophylactic antibiotic administration in Holmium Laser enucleation of the prostate (HoLEP): a randomized controlled trial"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5695-2794","authenticated-orcid":false,"given":"Katsumi","family":"Shigemura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fukashi","family":"Yamamichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-3400","authenticated-orcid":false,"given":"Kento","family":"Nishimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"386-94","DOI":"10.1016\/j.eururo.2012.09.038","article-title":"Antibiotic 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Kiyo."},{"key":"ref-8","article-title":"Replication data for Protocol for a comparison study of 1-day versus 2-day prophylactic antibiotic administration in Holmium Laser enucleation of the prostate (HoLEP): a randomized controlled trial.","author":"K Shigemura","year":"2019","journal-title":"Harvard Dataverse, V1."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"45-50","DOI":"10.4103\/0974-7796.198904","article-title":"Outcomes of transurethral resection and holmium laser enucleation in more than 60 g of prostate: A prospective randomized study.","volume":"9","author":"A Jhanwar","year":"2017","journal-title":"Urol Ann."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"CD011360","DOI":"10.1002\/14651858.CD011360.pub2","article-title":"Written information for patients (or parents of child patients) to reduce the use of antibiotics for acute upper respiratory tract infections in primary care.","volume":"11","author":"J O\u2019Sullivan","year":"2016","journal-title":"Cochrane Datebase Syst Rev."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"325-31","DOI":"10.1016\/j.jhin.2018.03.005","article-title":"The first multi-centre point-prevalence survey in four Japanese university hospitals.","volume":"99","author":"H Morioka","year":"2018","journal-title":"J Hosp Infect."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"593-8","DOI":"10.4111\/kju.2014.55.9.593","article-title":"The real practice of antibiotic prophylaxis for prostate biopsy in Korea where the prevalence of quinolone-resistant Escherichia coli is high.","volume":"55","author":"D Kim","year":"2014","journal-title":"Korean J Urol."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"S122-9","DOI":"10.1038\/nm1145","article-title":"Antibacterial resistance worldwide: causes, challenges and responses.","volume":"10","author":"S Levy","year":"2004","journal-title":"Nat Med."},{"key":"ref-14","first-page":"48-57","article-title":"[Antibiotics in transurethral resection of the prostate in patients with low risk of infectious complications: randomized prospective comparative study].","volume":"57","author":"J Valdevenito Sep\u00falveda","year":"2004","journal-title":"Arch Esp Urol."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"814-824","DOI":"10.1111\/iju.13161","article-title":"Essential Japanese guidelines for the prevention of perioperative infections in the urological field: 2015 edition.","volume":"23","author":"S Yamamoto","year":"2016","journal-title":"Int J Urol."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"338-42","DOI":"10.1016\/j.urology.2015.04.028","article-title":"Predictors of Enucleation and Morcellation Time During Holmium Laser Enucleation of the Prostate.","volume":"86","author":"M 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Int."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"674-9","DOI":"10.1016\/j.juro.2007.09.090","article-title":"Antibiotic prophylaxis for the prevention of recurrent urinary tract infection in children with low grade vesicoureteral reflux: results from a prospective randomized study.","volume":"179","author":"G Roussey-Kesler","year":"2008","journal-title":"J Urol."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"1919-24","DOI":"10.1097\/01.ju.0000140729.07840.16","article-title":"Randomized, double-blind placebo controlled trial of the once daily antimuscarinic agent solifenacin succinate in patients with overactive bladder.","volume":"172","author":"L Cardozo","year":"2004","journal-title":"J 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.21093.r48237, Seung-Ju Lee, Department of Urology, St Vincent's Hospital, The Catholic University of Korea, Paldal-gu, Suwon, South Korea, 16 May 2019, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/8-161\/v2#referee-response-48237","order":0,"name":"referee-response-48237","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.19311.r47977, Florian Wagenlehner, Clinic & Policlinic for Urology, Pediatric Urology & Andrology, Justus-Liebig University, Giessen, Germany, 02 May 2019, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/8-161\/v1#referee-response-47977","order":1,"name":"referee-response-47977","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Katsumi Shigemura<\/b>; \n<i>Posted: 02 May 2019<\/i>; Thanks, we added the patients with&nbsp;leucocyturia and reflected on the text (See in&nbsp;Eligibility criteria).We revised as same way in another part (See in Screening test).","URL":"https:\/\/f1000research.com\/articles\/8-161\/v2#referee-comment-4617","order":2,"name":"referee-comment-4617","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study is funded by research contribution in Department of Urology, Kobe University Hospital. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}