{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:42Z","timestamp":1772168922267,"version":"3.50.1"},"reference-count":117,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Society of Endodonology","award":["ESE research grant 2015"],"award-info":[{"award-number":["ESE research grant 2015"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Wnt signaling is of high relevance in the development, homeostasis, and regeneration of oral tissues. Therefore, Wnt signaling is considered to be a potential target for therapeutic strategies. The action of Wnt is tightly controlled by the inhibitors sclerostin (SOST) and Dickkopf (DKK)-1. Given the impact of SOST and DKK-1 in hard tissue formation, related diseases and healing, it is of high relevance to understand their role in oral tissues. The clinical relevance of this knowledge is further underlined by systemic and local approaches which are currently in development for treating a variety of diseases such as osteoporosis and inflammatory hard tissue resorption. In this narrative review, we summarize the current knowledge and understanding on the Wnt signaling inhibitors SOST and DKK-1, and their role in physiology, pathology, and regeneration in oral tissues. We present this role from the perspective of the different specialties in dentistry, including endodontics, orthodontics, periodontics, and oral surgery.<\/ns4:p>","DOI":"10.12688\/f1000research.17801.1","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T13:01:19Z","timestamp":1548853279000},"page":"128","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The role of sclerostin and dickkopf-1 in oral tissues \u2013 A review from the perspective of the dental 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.19462.r43827, Francisco Javier Rodr\u00edguez-Lozano, Cellular Therapy and Hematopoietic Transplant Unit, Hematology Department, Virgen de la Arrixaca Clinical University Hospital, IMIB-Arrixaca, University of Murcia, Murcia, Spain, 04 Feb 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-128\/v1#referee-response-43827","order":0,"name":"referee-response-43827","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.19462.r46090, Qiming Jin, Department of Cariology,\u00a0Restorative Sciences, and\u00a0Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA, 15 Apr 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-128\/v1#referee-response-46090","order":1,"name":"referee-response-46090","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"We thank the European Society of Endodontology (ESE) for financial support of our research [ESE research grant 2015]. The authors deny any conflict of interest. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}