{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:58:25Z","timestamp":1781650705122,"version":"3.54.5"},"reference-count":8,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Several case reports have been published describing the coexistence of sarcoidosis and cancer. In the literature, simultaneous occurrence of head and neck cancer and sarcoidosis is rarely reported.<\/ns4:p>\n                  <ns4:p>In this paper we present a case of a 42-year-old man with squamous cell carcinoma of the oral cavity, locally advanced, which after surgery and adjuvant radiotherapy developed local persistence and progression in the mediastinal lymph nodes. The patient was submitted to chemotherapy and after a complete response, new suspicious mediastinal and hilar lymph nodes appeared in the thoracic computed tomography (CT) scan and\u00a018F-fluorodeoxyglucose positron emission\u00a0tomography (FDG-PET) scan. To enroll the patient in a clinical trial, the patient underwent mediastinoscopy with mediastinal lymph node dissection. The histopathological findings were consistent with sarcoidosis and no metastatic disease was found. Since the patient had no symptoms and the levels of serum angiotensin converting enzyme\u00a0were normal, no further pharmacological intervention was done. After 4 years of follow up the patient remains without evidence of cancer.<\/ns4:p>\n                  <ns4:p>This case shows that although imagological techniques (CT and FDG-PET scan) are extensively used to assess the tumor response, false-positive cases can occur. Whenever it is possible a biopsy of the suspected metastatic site should always be performed.<\/ns4:p>","DOI":"10.12688\/f1000research.17834.1","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T04:00:10Z","timestamp":1551067210000},"page":"215","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Sarcoidosis mimicking head and neck cancer progression"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-4505","authenticated-orcid":false,"given":"Edgar","family":"Pratas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Domingues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Khouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Eufr\u00e1sio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isonda","family":"Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2019,2,25]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"1155-1167","DOI":"10.1016\/S0140-6736(13)60680-7","article-title":"Sarcoidosis.","volume":"383","author":"D Valeyre","year":"2014","journal-title":"Lancet."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1427-34","DOI":"10.1093\/annonc\/mdq614","article-title":"Survival in cancer patients with previous hospitalization for sarcoidosis: a Swedish population-based cohort study during 1964-2006.","volume":"22","author":"X Shu","year":"2011","journal-title":"Ann Oncol."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"7643-7652","DOI":"10.3892\/ol.2017.7247","article-title":"Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma.","volume":"14","author":"C Spiekermann","year":"2017","journal-title":"Oncol Lett."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"529-534","DOI":"10.1053\/j.seminoncol.2013.05.015","article-title":"Sarcoidosis mimicking metastatic bone disease in head and neck cancer.","volume":"40","author":"C Arana Yi","year":"2013","journal-title":"Semin Oncol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"640-641","DOI":"10.1200\/JCO.2005.02.089","article-title":"Benign lesions in cancer patients: Case 1. Sarcoidosis after chemoradiation for head and neck cancer.","volume":"23","author":"M Yao","year":"2005","journal-title":"J Clin Oncol."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"496-507","DOI":"10.1056\/NEJMra050276","article-title":"Positron-emission tomography and assessment of cancer therapy.","volume":"354","author":"M Juweid","year":"2006","journal-title":"N Engl J Med."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"e1146","DOI":"10.7759\/cureus.1146","article-title":"False Positive Positron Emission Tomography \/ Computed Tomography Scans in Treated Head and Neck Cancers.","volume":"9","author":"M Cheung","year":"2017","journal-title":"Cureus."},{"key":"ref-8","first-page":"2698-2708","article-title":"Sarcoidosis of mediastinal lymph nodes mimicking distant metastasis of oral squamous cell carcinoma: a case report and review of literature.","volume":"11","author":"T Maruyama","year":"2018","journal-title":"Int J Clin Exp Med."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/8-215\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-215\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-215\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T05:45:09Z","timestamp":1570081509000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/8-215\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,25]]},"references-count":8,"URL":"https:\/\/doi.org\/10.12688\/f1000research.17834.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.19499.r54554","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.19499.r44879","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.19499.r44879","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.19499.r54554","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,25]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/8-215\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.19499.r44879, Robin J.D. Prestwich, Department of Clinical Oncology, St. James's University Hospital, \u00a0Leeds Cancer Centre, \u00a0Leeds, UK, 04 Mar 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-215\/v1#referee-response-44879","order":0,"name":"referee-response-44879","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.19499.r54554, Christoph Spiekermann, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital M\u00fcnster, M\u00fcnster, Germany, 03 Oct 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-215\/v1#referee-response-54554","order":1,"name":"referee-response-54554","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}