{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:51:28Z","timestamp":1791895888414,"version":"4.3.4"},"update-to":[{"DOI":"10.12688\/f1000research.178649.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000}}],"reference-count":19,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Introduction Invasive aspergillosis is a severe infection that usually affects immunocompromised patients. Primary cutaneous involvement is a rare presentation and presents a challenge for early diagnosis. We report a case of primary cutaneous aspergillosis (PCA) in an immunocompromised patient with no evident prior skin trauma and with pulmonary dissemination. Case report We report the case of primary cutaneous aspergillosis involving the left ankle in a 5-year-old girl with no history of preceding trauma. The patient was undergoing chemotherapy for lymphoblastic leukemia.\n                    <ns3:italic>Aspergillus<\/ns3:italic>\n                    hyphae were identified on skin biopsy. Cultures grew\n                    <ns3:italic>Aspergillus flavus.<\/ns3:italic>\n                    The diagnosis of cutaneous aspergillosis enabled the diagnosis of probable pulmonary aspergillosis, although there was no mycopathological proof of lung infection. The patient was treated with initial Amphotericin B followed by Voriconazole with complete skin and respiratory response. Conclusion This case underscores the critical need to consider cutaneous aspergillosis in immunocompromised patients with necrotic skin lesions\u2014 even in the absence of obvious trauma\u2014as prompt diagnosis and treatment are vital to prevent dissemination and and improve outcomes.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.178649.2","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:34:06Z","timestamp":1781001246000},"page":"454","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Primary Cutaneous Aspergillosis in a Neutropenic Child with Pulmonary Dissemination: A case report"],"prefix":"10.12688","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3616-2164","authenticated-orcid":false,"given":"Yasmine","family":"KALBOUSSI","sequence":"first","affiliation":[{"name":"Laboratory of Parasitology - Mycology Sousse Sousse Farhat Hached University Hospital of Sousse"},{"name":"Monastir Monastir University of Monastir Faculty of Medicine of Monastir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafa","family":"CHENBAH","sequence":"additional","affiliation":[{"name":"Department of Hematology Sousse Sousse Farhat Hached University Hospital of Sousse"},{"name":"Sousse Sousse University of Sousse Faculty of Medicine of Sousse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"CHOUAIEB","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology - Mycology Sousse Sousse Farhat Hached University Hospital of Sousse"},{"name":"Sousse Sousse University of Sousse Faculty of Medicine of Sousse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"GAALOUL","sequence":"additional","affiliation":[{"name":"Department of Hematology Sousse Sousse Farhat Hached University Hospital of Sousse"},{"name":"Sousse Sousse University of Sousse Faculty of Medicine of Sousse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6152-0988","authenticated-orcid":false,"given":"Samar","family":"ISMAIL","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology - Mycology Sousse Sousse Farhat Hached University Hospital of Sousse"},{"name":"Sousse Sousse University of Sousse Faculty of Medicine of Sousse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"GUERMAZI","sequence":"additional","affiliation":[{"name":"Department of Hematology Sousse Sousse Farhat Hached University Hospital of Sousse"},{"name":"Sousse Sousse University of Sousse Faculty of Medicine of Sousse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem","family":"BEN TICHA","sequence":"additional","affiliation":[{"name":"Sousse Sousse University of Sousse Faculty of Medicine of Sousse"},{"name":"Department of Infectious diseases Sousse Sousse Farhat Hached University Hospital of Sousse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imene","family":"KHAMMARI","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology - 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Dis."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"408-415","DOI":"10.1056\/NEJMoa020191","article-title":"Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis.","volume":"347","author":"R Herbrecht","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e3747","DOI":"10.1097\/MD.0000000000003747","article-title":"Factors affecting patient outcome in primary cutaneous aspergillosis.","volume":"95","author":"A Tatara","year":"2016","journal-title":"Medicine (Baltimore)."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2511-2516","DOI":"10.1128\/AAC.40.11.2511","article-title":"In vitro interaction between amphotericin B and azoles in Candida albicans.","volume":"40","author":"J Vazquez","year":"1996","journal-title":"Antimicrob. 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