{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:26Z","timestamp":1772168966369,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.18062.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000}},{"DOI":"10.12688\/f1000research.18062.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000}},{"DOI":"10.12688\/f1000research.18062.3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000}},{"DOI":"10.12688\/f1000research.18062.4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000}}],"reference-count":54,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007482","name":"Arizona State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007482","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008982","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1539129SBERIDIR"],"award-info":[{"award-number":["1539129SBERIDIR"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Arizona State University Institute for Social Science Research"},{"DOI":"10.13039\/100001906","name":"Washington Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001906","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Speech and language therapy is typically initiated reactively after a child shows delays. Infants with classic galactosemia (CG), a metabolic disease with a known high risk for both speech and language disorders, hold the keys towards evaluating whether preventive treatment is effective when the risks are known at birth.\u00a0We present pilot data from a randomized parallel trial of an innovative proactive speech and language intervention program, the Babble Boot Camp (BBC).\u00a0\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Method<\/ns4:bold>\n                    : Five children with CG, otherwise healthy, participated in the study from approximately 2 to 24 months of age. One of these was randomly selected as control receiving conventional management, which typically starts at age 2-3 years. A pediatric speech-language pathologist met weekly via telepractice with the parents in the treatment cohort. Parents implemented the prespeech, speech, and language stimulation and expansion activities according to the intervention protocol. The control child was still too young for conventional treatment. Primary outcome measures were speech sound production complexity in babble and speech and expressive vocabulary size. Secondary outcome measures were vocalization rates and developmental milestones in communication, motor, and cognition. The trial is ongoing.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results<\/ns4:bold>\n                    :\u00a0 All four treated children had higher speech sound skills in babble, three had higher speech sound skills in meaningful speech, two had higher expressive vocabularies, three had higher global developmental scores, and two had higher vocalization rates, compared to the control child with CG.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Discussion:<\/ns4:bold>\n                    Given the high risk for speech and language delays in children with CG, finding on-schedule abilities in two or more of the treated children but not the untreated child is unexpected under random conditions. The trends toward beneficial effects of the BBC on speech sound production, expressive language, and communication milestones warrant appropriately powered larger clinical trials with full randomization.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Trial registration:<\/ns4:bold>\n                    ClinicalTrials.gov\n                    <ns4:ext-link xmlns:ns3=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" ns3:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03838016\">NCT03838016<\/ns4:ext-link>\n                    (12\n                    <ns4:sup>th<\/ns4:sup>\n                    February 2019).\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.18062.5","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T09:15:09Z","timestamp":1594026909000},"page":"271","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Toward a paradigm shift from deficit-based to proactive speech and language treatment: Randomized pilot trial of the Babble Boot Camp in infants with classic galactosemia"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-8522","authenticated-orcid":false,"given":"Beate","family":"Peter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inbal","family":"Donenfeld-Peled","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizbeth","family":"Finestack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Stoel-Gammon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Lien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9620-3157","authenticated-orcid":false,"given":"Laurel","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Vose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Eng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanako","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Olds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1906-5774","authenticated-orcid":false,"given":"Mark","family":"VanDam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"ref-41","doi-asserted-by":"publisher","first-page":"41-50","DOI":"10.1177\/1096250615598815","article-title":"Coaching 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Wetherby","year":"2014","journal-title":"Pediatrics."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/8-271\/v5\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-271\/v5\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-271\/v5\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T09:15:17Z","timestamp":1594026917000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/8-271\/v5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,6]]},"references-count":54,"URL":"https:\/\/doi.org\/10.12688\/f1000research.18062.5","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.27718.r66483","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,6]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/8-271\/v5#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.24580.r59625, Shelley Velleman, Claudia Abbiati, \u00a0Department of Communication Sciences and Disorders, University of Vermont, Burlington, VT, USA, 02 Mar 2020, version 3, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/8-271\/v3#referee-response-59625","order":0,"name":"referee-response-59625","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Beate Peter<\/b>; \n<i>Posted: 17 Mar 2020<\/i>; We appreciate Reviewer 1\u2019s third review. In the previous revision, we had addressed Reviewer 2\u2019s concerns and addressed Reviewer 1\u2019s new concerns as follows:&nbsp;Inter-rater reliability: To obtain inter-rater reliability, 10% of the sound files were transcribed by a different transcriber who also computed MBL and SSL values for the reliability transcription. Differences between the first and second scores were calculated as an absolute value and expressed as a percent score relative to the average difference between the first and second scores. The average difference amounted to 8.5%, which is acceptable. The second reliability procedure, a complete recalculation of all MBL and SSL scores by a different team member, was based on the original transcriptions. Any computational errors that were identified with a discrepancy between the first and second score were corrected and the validated values were entered into the final database.&nbsp;MBL and SSL sample selection: Reviewer 1 pointed out that studies of typical children are based on naturalistic half- or whole-hour recordings whereas we selected 5-minute segments with the highest volubility from a day-long recording. This is an excellent point regarding our study design that ideally would have been made in the first round of review. We added explanatory text to the Methods and revised the interpretation of our results, which make a lot more sense now.&nbsp;Writing style: We had implemented 11 of the 16 suggestions for improving the writing style. Of five cases flagged as run-on or long sentences, we have now broken down two into shorter components but in the remaining three, we preferred our own wording. In this revision, we made a few additional improvements of spelling and punctuation. Since no details regarding style were mentioned in this review, we trust that our writing style is acceptable now.","URL":"https:\/\/f1000research.com\/articles\/8-271\/v5#referee-comment-5317","order":1,"name":"referee-comment-5317","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.25295.r61857, Barbara L. Davis, Department of Communication Sciences and Disorders, University of Texas at Austin, Austin, TX, USA, 14 Apr 2020, version 4, indexed","URL":"https:\/\/f1000research.com\/articles\/8-271\/v4#referee-response-61857","order":2,"name":"referee-response-61857","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.25295.r63031, Rebecca McCauley, Department of Speech and Hearing Science, The Ohio State University, Columbus, OH, USA, 11 Jun 2020, version 4, indexed","URL":"https:\/\/f1000research.com\/articles\/8-271\/v4#referee-response-63031","order":3,"name":"referee-response-63031","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Beate Peter<\/b>; \n<i>Posted: 27 Jun 2020<\/i>; Many thanks for this very thorough and helpful review. We greatly appreciate the suggestions for the present manuscript and also for the larger clinical trial regarding barriers to implementation fidelity and reporting standards. We have addressed the concerns as follows:- Added an appendix that lists and describes all intervention components of the study. The descriptions of the activities and routines were excerpted from the program overview that parents receive at the start of the intervention.- Contextualized our transcription reliability by converting the accuracy measure from differences to agreement and by showing that our agreement rates were nearly identical to those in the original MBL paper.- Outlined the implementation and reporting procedures in place for the clinical trial that followed the pilot study described in the present manuscript.- Described implementation and fidelity measures planned for future expansions of this project, not only in terms of additional research but, eventually, in terms of clinical practice.We made a few additional minor changes, e.g., corrected some typographical errors that had previously escaped notice and updated some of the information.","URL":"https:\/\/f1000research.com\/articles\/8-271\/v5#referee-comment-5668","order":4,"name":"referee-comment-5668","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by a seed grand from the Arizona State University Institute for Social Science Research and an Arizona State University New Faculty Startup Fund award to B. Peter and by NSF SBE RIDIR 1539129 and the Washington Research Foundation to M. VanDam. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":5,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}