{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:26Z","timestamp":1772168966478,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.18129.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000}}],"reference-count":6,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Acute pyelonephritis is a common renal manifestation in patients with diabetes. A 52-year-old diabetic lady presented with loin pain, dysuria, and fever and urinary incontinence that had begun seven and three days prior to presentation respectively. She was treated with escalating spectra of intravenous antibiotics without improvement. Urine and blood cultures were sterile, while radiological investigations were suggestive of pyelonephritis. Mild hepatic dysfunction prompted consideration of scrub typhus and she improved with empirical doxycycline. Scrub IgM was later confirmed to be positive. In conclusion, local prevalence of systemic infections such as rickettsioses should always be considered in diabetics with fever, even if symptoms and signs otherwise suggest typical diabetes-related infections. We, therefore report a case of acute pyelonephritis caused by scrub typhus which has not been previously described in English medical literature.<\/ns4:p>","DOI":"10.12688\/f1000research.18129.2","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T03:45:13Z","timestamp":1562298313000},"page":"312","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Acute pyelonephritis and hearing loss in scrub typhus"],"prefix":"10.12688","volume":"8","author":[{"given":"Sivaranjini","family":"Venketesan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dheeraj","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5861-5161","authenticated-orcid":false,"given":"Stalin","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murugesan Sivagurunathan","family":"Gayathri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"ref-1","first-page":"85-103","article-title":"Kidney infections in diabetes mellitus.","volume":"31","author":"M Balachandar","year":"2002","journal-title":"Diabetol Croat."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"3488-93","DOI":"10.1093\/ndt\/gfr810","article-title":"Acute pyelonephritis in adults: a case series of 223 patients.","volume":"27","author":"C Rollino","year":"2012","journal-title":"Nephrol Dial Transplant."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"e013882","DOI":"10.1136\/bmjopen-2016-013882","article-title":"Incidence, risk factors and clinical outcomes of acute kidney injury associated with scrub typhus: a retrospective study of 510 consecutive patients in South Korea (2001-2013).","volume":"7","author":"K Hwang","year":"2017","journal-title":"BMJ Open."},{"key":"ref-4","first-page":"329","article-title":"[One case of scrub typhus patient with clinical manifestation of acute pyelonephritis].","volume":"31","author":"L Shu","year":"2013","journal-title":"Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi."},{"key":"ref-5","first-page":"24-8","article-title":"Outbreak of scrub typhus in Pondicherry.","volume":"58","author":"M Vivekanandan","year":"2010","journal-title":"J Assoc Physicians India."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"e6-8","DOI":"10.1086\/498747","article-title":"Acute hearing loss due to scrub typhus: a forgotten complication of a reemerging disease.","volume":"42","author":"R Premaratna","year":"2006","journal-title":"Clin Infect Dis."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/8-312\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-312\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-312\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T05:45:10Z","timestamp":1562305510000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/8-312\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,5]]},"references-count":6,"URL":"https:\/\/doi.org\/10.12688\/f1000research.18129.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.21739.r50808","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.21739.r50808","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,5]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/8-312\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.19827.r45955, Ravindra Prabhu Attur, Dharshan Rangaswamy, Department of Nephrology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India, 03 Apr 2019, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/8-312\/v1#referee-response-45955","order":0,"name":"referee-response-45955","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Stalin Viswanathan<\/b>; \n<i>Posted: 26 Jun 2019<\/i>; Dear Sir,The lady did not receive any prior treatment. The details have been included.It was not a chance sending of Scrub IgM. That facility is not available at our institution. Since LFT was done only on day 4, we could send a sample for Scrub IgM to a private lab only on day5.Malarial parasites were not visualized on peripheral smear. Moreover, the LFT dysfunction was without hyperbilirubinemia.All these details were not mentioned since this manuscript was submitted to another journal previously with a word count of 1000, and such information fell prey to the editing keys.Unusual was the absence of eschar, but it is well known in Indian populations that the incidence of eschar is varying between 4-46% (Vivekanandan \n<i>et al<\/i>, 2010).Thrombocytopenia was expected in a case of scrub typhus, and such a finding would have enabled us to pursue a diagnosis of scrub typhus earlier, even before the LFT.","URL":"https:\/\/f1000research.com\/articles\/8-312\/v2#referee-comment-4706","order":1,"name":"referee-comment-4706","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.21739.r50808, Tri Wangrangsimakul, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 05 Jul 2019, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/8-312\/v2#referee-response-50808","order":2,"name":"referee-response-50808","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}