{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:51:47Z","timestamp":1775026307328,"version":"3.50.1"},"reference-count":9,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    \u00a0Herein we report a rare case of acute liver failure due to levetiracetam, which has been considered to have an excellent safety profile with minimal hepatic side effects.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Case presentation:<\/ns4:bold>\n                    \u00a0A 55-year-old male patient presenting with sudden onset dizziness, slurring of speech and headache was operated for posterior fossa cerebellar hematoma. His post-surgical period was complicated by development of icterus with elevation of liver enzymes. After ruling out common inciting factors, it was decided to stop levetiracetam which was given prophylactically for preventing seizures owing to presence of external ventricular drain. From the next day patient had dramatic improvement in liver functions and sensorium.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    \u00a0We would like to highlight this side effect that is potentially life threatening, though rare, of levetiracetam, which is very commonly used in today\u2019s practice and fast superseding all other time-tested antiepileptics.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.18198.1","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T04:18:05Z","timestamp":1550204285000},"page":"187","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Case Report: Levetiracetam causing acute liver failure complicating post-operative management in a neurosurgical patient"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1809-3407","authenticated-orcid":false,"given":"Sharanya","family":"Jayashankar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-3792","authenticated-orcid":false,"given":"Sunil","family":"Munakomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vignesh","family":"Sayeerajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-1128","authenticated-orcid":false,"given":"Prakash","family":"Kafle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramod","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagdishchandra","family":"Thingujam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Poudel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1750-7740","authenticated-orcid":false,"given":"Iype","family":"Cherian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"e385-e392","DOI":"10.1016\/j.wneu.2018.01.052","article-title":"Seizures After Intracerebral Hemorrhage: Incidence, Risk Factors, and Impact on Mortality and Morbidity.","volume":"112","author":"A Mehta","year":"2018","journal-title":"World Neurosurg."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"23-36","DOI":"10.1016\/j.pediatrneurol.2017.09.013","article-title":"Antiepileptic Drugs and Liver Disease.","volume":"77","author":"J Vidaurre","year":"2017","journal-title":"Pediatr Neurol."},{"key":"ref-3","article-title":"Topical Review-Antiepileptic Drugs and Liver Disease; Division of Pediatric Neurology, Department of Pediatrics, Nationwide Children\u2019s Hospital, Columbus, Ohio","author":"J Vidaurre"},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"685-6","DOI":"10.1212\/01.wnl.0000324604.11657.c6","article-title":"Levetiracetam as a possible cause of fulminant liver failure.","volume":"71","author":"T Tan","year":"2008","journal-title":"Neurology."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"41-4","DOI":"10.4236\/crcm.2012.12010","article-title":"Acute liver failure following levetiracetam therapy for seizure prophylaxis in traumatic brain injury.","volume":"1","author":"A Syed","year":"2012","journal-title":"Case Rep Clin Med."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"123-4","DOI":"10.1515\/dmdi-2013-0006","article-title":"Asymptomatic elevation of liver enzymes due to levetiracetam: a case report.","volume":"28","author":"N Sethi","year":"2013","journal-title":"Drug Metabol Drug Interact."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"1590-1594","DOI":"10.1161\/01.STR.28.8.1590","article-title":"Predictive factors of early seizures after acute cerebrovascular disease.","volume":"28","author":"A Arboix","year":"1997","journal-title":"Stroke."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"36-9","DOI":"10.1111\/j.1528-1167.2001.00008.x","article-title":"Safety profile of levetiracetam.","volume":"42 Suppl 4","author":"C Harden","year":"2001","journal-title":"Epilepsia."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"1323-1330","DOI":"10.1016\/0895-4356(93)90101-6","article-title":"Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.","volume":"46","author":"G Danan","year":"1993","journal-title":"J Clin Epidemiol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/8-187\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-187\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-187\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T02:15:09Z","timestamp":1573006509000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/8-187\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,15]]},"references-count":9,"URL":"https:\/\/doi.org\/10.12688\/f1000research.18198.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.19906.r46050","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.19906.r46049","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.19906.r46049","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.19906.r46050","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,15]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/8-187\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.19906.r46050, Subish Palaian, Department of Pharmacy Practice, College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates, 25 Mar 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-187\/v1#referee-response-46050","order":0,"name":"referee-response-46050","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.19906.r46049, Pathiyil\u00a0Ravi Shankar, Department of Pharmacology, Health City University, Gros Islet, Saint Lucia, 01 Apr 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-187\/v1#referee-response-46049","order":1,"name":"referee-response-46049","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}