{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:32:10Z","timestamp":1790991130771,"version":"4.1.0"},"reference-count":65,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["284605"],"award-info":[{"award-number":["284605"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["295738"],"award-info":[{"award-number":["295738"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004012","name":"Jane and Aatos Erkko Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Research Council of Norway","award":["Centre of excellence (CCBIO) grant 223250"],"award-info":[{"award-number":["Centre of excellence (CCBIO) grant 223250"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>The efficient healing of skin wounds is crucial for securing the vital barrier function of the skin, but pathological wound healing and scar formation are major medical problems causing both physiological and psychological challenges for patients. A number of tightly coordinated regenerative responses, including haemostasis, the migration of various cell types into the wound, inflammation, angiogenesis, and the formation of the extracellular matrix, are involved in the healing process. In this article, we summarise the central mechanisms and processes in excessive scarring and acute wound healing, which can lead to the formation of keloids or hypertrophic scars, the two types of fibrotic scars caused by burns or other traumas resulting in significant functional or aesthetic disadvantages. In addition, we discuss recent developments related to the functions of activated fibroblasts, the extracellular matrix and mechanical forces in the wound environment as well as the mechanisms of scarless wound healing. Understanding the different mechanisms of wound healing is pivotal for developing new therapies to prevent the fibrotic scarring of large skin wounds.<\/ns4:p>","DOI":"10.12688\/f1000research.18293.1","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T20:40:07Z","timestamp":1559767207000},"page":"787","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":203,"title":["Toward understanding scarless skin wound healing and pathological 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.20011.r48945, Jouni Uitto, Department of Dermatology and Cutaneous Biology, The Sidney Kimmel Medical College at Thomas Jefferson University, Jefferson Institute of Molecular Medicine, Philadelphia, USA, 06 Jun 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-787\/v1#referee-response-48945","order":0,"name":"referee-response-48945","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.20011.r48946, Boris Hinz, Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Canada, 06 Jun 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-787\/v1#referee-response-48946","order":1,"name":"referee-response-48946","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The research of S-MK, RH and TP is supported by the Academy of Finland (grant 284605), the Jane and Aatos Erkko Foundation, and the Sigrid Jus\u00e9lius Foundation. DG and RH are supported by the Research Council of Norway (Centre of Excellence [CCBIO] grant ID 223250), and KT is supported by the Academy of Finland (grant 295738) and the Sigrid Jus\u00e9lius Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}