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Balerna","year":"1975","journal-title":"Biochemistry."},{"key":"ref-60","doi-asserted-by":"publisher","first-page":"1158-67","DOI":"10.1164\/rccm.201406-1136OC","article-title":"Obstructive sleep apnea during REM sleep and hypertension. results of the Wisconsin Sleep Cohort.","volume":"190","author":"B Mokhlesi","year":"2014","journal-title":"Am J Respir Crit Care Med."},{"key":"ref-61","doi-asserted-by":"publisher","first-page":"303-7","DOI":"10.1056\/NEJM199302043280502","article-title":"Sympathetic-nerve activity during sleep in normal subjects.","volume":"328","author":"V Somers","year":"1993","journal-title":"N Engl J Med."},{"key":"ref-62","doi-asserted-by":"publisher","first-page":"322-325","DOI":"10.1378\/chest.123.2.322","article-title":"Pembrey\u2019s Dream.","volume":"123","author":"S Javaheri","year":"2003","journal-title":"Chest."},{"key":"ref-63","doi-asserted-by":"publisher","first-page":"149-57","DOI":"10.1016\/j.sleep.2015.10.017","article-title":"Nocturnal oxygen 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Ding","year":"2008","journal-title":"J Appl Physiol (1985)."},{"key":"ref-76","doi-asserted-by":"publisher","first-page":"1151-1159","DOI":"10.1038\/nm.4173","article-title":"Purinergic receptors in the carotid body as a new drug target for controlling hypertension.","volume":"22","author":"W Pijacka","year":"2016","journal-title":"Nat Med."},{"key":"ref-77","doi-asserted-by":"publisher","first-page":"178-184","DOI":"10.1089\/ham.2017.0147","article-title":"Adaptive Servoventilation as Treatment for Central Sleep Apnea Due to High-Altitude Periodic Breathing in Nonacclimatized Healthy Individuals.","volume":"19","author":"J Orr","year":"2018","journal-title":"High Alt Med Biol."},{"key":"ref-78","doi-asserted-by":"publisher","first-page":"61-70","DOI":"10.1089\/ham.2018.0074","article-title":"The Effect of an Expiratory Resistance Mask with Dead Space on Sleep, Acute Mountain Sickness, Cognition, and Ventilatory Acclimatization in Normobaric Hypoxia.","volume":"20","author":"A Patrician","year":"2019","journal-title":"High Alt Med Biol."},{"key":"ref-79","doi-asserted-by":"publisher","first-page":"131-138","DOI":"10.1378\/chest.11-0375","article-title":"Patients with obstructive sleep apnea syndrome benefit from acetazolamide during an altitude sojourn: a randomized, placebo-controlled, double-blind trial.","volume":"141","author":"Y Nussbaumer-Ochsner","year":"2012","journal-title":"Chest."},{"key":"ref-80","doi-asserted-by":"publisher","first-page":"2167-74","DOI":"10.1097\/j.pain.0000000000000279","article-title":"Sleep-disordered breathing decreases after opioid withdrawal: results of a prospective controlled trial.","volume":"156","author":"A 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.20084.r49766, Danny Eckert, Adelaide Institute for Sleep Health (AISH): A Flinders Centre of Research Excellence, College of Medicine and Public Health, Flinders University, Adelaide, Australia, 28 Jun 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-981\/v1#referee-response-49766","order":0,"name":"referee-response-49766","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.20084.r49765, Michael Khoo, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA, 28 Jun 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-981\/v1#referee-response-49765","order":1,"name":"referee-response-49765","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Original research cited in the article was supported by the National Heart, Lung, and Blood Institute (R21 HL137874). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}