{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:05:10Z","timestamp":1779879910625,"version":"3.53.1"},"reference-count":13,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background<\/ns3:bold>\n                    : Penile necrosis is a rare condition that may present in patients with diabetes mellitus or chronic kidney disease (CKD). The recommended treatment is controversial. We report a case of penile necrosis in a diabetic patient caused by episode of paraphimosis associated with uremic arteriopathy treated with partial amputation.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Clinical Case<\/ns3:bold>\n                    : A 53-year-old male with a background of arterial hypertension, diabetes mellitus and CKD in hemodialysis. The patient presented with paraphimosis and glans necrosis. An emergency circumcision was carried out. A doppler ultrasound found fluid collection in the left corpus cavernosum, parietal vascular calcifications and vascular insufficiency in the corpus cavernosum that suggested necrosis. A partial amputation of the penis was carried out. After three years of follow-up, the outcome has remained favorable.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusions<\/ns3:bold>\n                    : Penile necrosis is a rare but serious complication of terminal CKD. In these patients, systemic calciphylaxis is usually observed. The main take-away lesson is that a multidisciplinary approach is necessary.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.18834.1","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T09:45:10Z","timestamp":1563529510000},"page":"1133","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Case Report: Penile necrosis associated to paraphimosis with calciphylaxis due to terminal chronic kidney disease"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4876-3755","authenticated-orcid":false,"given":"J. Antonio","family":"Grandez-Urbina","sequence":"first","affiliation":[{"name":"Calle Jun\u00edn 355, Miraflores, Lima 15046 Universidad Continental"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Corrales-Acosta","sequence":"additional","affiliation":[{"name":"Urology Deparment Avenida Argentina 29, Callao 07001 Hospital Alberto Leopoldo Barton Thompson"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Eduardo","family":"Tejeda-Mariaca","sequence":"additional","affiliation":[{"name":"Urology Department Jr. Colina 1081 Bellavista, Callao 07011 Hospital Nacional Alberto Sabogal Sologuren"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-4557","authenticated-orcid":false,"given":"Rafael","family":"Pichardo-Rodriguez","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute Avenida Alfredo Benavides 5430, Santiago de Surco, Lima 15039 Universidad Ricardo Palma"},{"name":"Avenida Javier Prado Este 3028, San Borja, Lima 15031 Clinica de Urologia Avanzada Urozen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herney","family":"Garcia-Perdomo","sequence":"additional","affiliation":[{"name":"Medicine School Calle 4B # 36-00, Cali Universidad del Valle"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"136-7","DOI":"10.5489\/cuaj.2331","article-title":"Penile lesion in end-stage renal failure - cancer or otherwise?: Calcific uremic arteriolopathy presenting with a penile lesion.","volume":"9","author":"T Malthouse","year":"2015","journal-title":"Can Urol Assoc J."},{"key":"ref-2","first-page":"137-43","article-title":"Calciphylaxis: a syndrome of skin necrosis and acral gangrene in chronic renal failure.","volume":"27","author":"J Hafner","year":"1998","journal-title":"Vasa."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"231-5","DOI":"10.1023\/A:1023258127729","article-title":"Progression to wet gangrene in penile necrosis and calciphylaxis.","volume":"34","author":"L Barthelmes","year":"2002","journal-title":"Int Urol Nephrol."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"e3334","DOI":"10.7759\/cureus.3334","article-title":"Chronic Kidney Disease and Calciphylaxis: A Literature Review.","volume":"10","author":"M Ahmed","year":"2018","journal-title":"Cureus."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"20-28","DOI":"10.1016\/j.nefro.2016.07.001","article-title":"Plant phosphates, phytate and pathological calcifications in chronic kidney disease.","volume":"37","author":"J Buades Fuster","year":"2017","journal-title":"Nefrologia."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"2206-9","DOI":"10.1097\/01.ju.0000064334.85656.a1","article-title":"Penile calciphylaxis: analysis of risk factors and mortality.","volume":"169","author":"E Karpman","year":"2003","journal-title":"J Urol."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"57-58","DOI":"10.1016\/j.eucr.2017.09.016","article-title":"Glans penis necrosis following paraphimosis: A rare case with brief literature review.","volume":"16","author":"F Palmisano","year":"2018","journal-title":"Urol Case Rep."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"536-539","DOI":"10.1097\/WON.0000000000000483","article-title":"Management of penile calciphylaxis. A Case Study.","volume":"45","author":"J Zillioux","year":"2018","journal-title":"J Wound Ostomy Continence Nurs."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"2014-6","DOI":"10.1016\/s0022-5347(17)32294-2","article-title":"Penile gangrene associated with chronic renal failure: report of 7 cases and review of the literature.","volume":"152","author":"M Stein","year":"1994","journal-title":"J Urol."},{"key":"ref-10","first-page":"10-4","article-title":"Necrosis de pene: Experiencia en el Hospital de Especialidades Centro M\u00e9dico Nacional Siglo XXI.","volume":"20","author":"G Mart\u00ednez","year":"2005","journal-title":"Bol Col Mex Urol."},{"key":"ref-11","first-page":"711-3","article-title":"Calciphylaxis leading to penile necrosis.","volume":"64","author":"I Haider","year":"2014","journal-title":"J Pak Med Assoc."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"113-116","DOI":"10.1016\/j.eucr.2017.03.008","article-title":"Penile Calciphylaxis: The Use of Radiological Investigations in the Management of a Rare and Challenging Condition.","volume":"13","author":"R Campbell","year":"2017","journal-title":"Urol Case Rep."},{"key":"ref-13","doi-asserted-by":"crossref","first-page":"47-50","DOI":"10.1177\/0391560310077016S11","article-title":"[Calciphylaxis and penile necrosis: a case report and review of the literature].","volume":"77","author":"M Grande","year":"2010","journal-title":"Urologia."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/8-1133\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-1133\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-1133\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:29:10Z","timestamp":1779877750000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/8-1133\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,19]]},"references-count":13,"URL":"https:\/\/doi.org\/10.12688\/f1000research.18834.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.20638.r51410","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.20638.r51408","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.20638.r51410","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.20638.r51408","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,19]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/8-1133\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.20638.r51410, Felix Grases, Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research (IUNICS- IdisBa), University of Balearic Islands, Palma de Mallorca, 30 Jul 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1133\/v1#referee-response-51410","order":0,"name":"referee-response-51410","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.20638.r51408, Munis M. Ahmed, Internal Medicine, Mayo Hospital, King Edward Medical University, Lahore, 06 Aug 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1133\/v1#referee-response-51408","order":1,"name":"referee-response-51408","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}