{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:10:54Z","timestamp":1793293854835,"version":"4.5.0"},"reference-count":68,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"None"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Seborrheic keratosis (SK) is a common benign epidermal tumor with predominance in adult patients. Whereas common SKs are more frequent in Caucasians, dermatosis papulosa nigra is more prevalent in patients with a Fitzpatrick skin type of at least 3. There seems to be a link between extrinsic skin aging and the occurrence of SK. Mutations of fibroblast growth factor receptor 3 and other signaling molecules are a frequent finding in SK lesions. However, this does not translate into any malignant potential. Viral infections are particularly common in genital lesions, although their pathogenetic relevance for SK is questionable. Different histologic and clinical subtypes have been identified. The great variability of SKs raises some difficulties in diagnosis. Dermoscopy is the preferred non-invasive diagnostic method, in particular to differentiate pigmented SKs from other pigment tumors, including cutaneous melanoma. Eruptive SKs can be a paraneoplastic condition known as the Leser\u2013Tr\u00e9lat sign. New targeted cancer treatments can cause a pseudo-Leser\u2013Tr\u00e9lat sign. The treatment in practice is mainly minor surgery, including cryosurgery, shave excisions, and laser-assisted removal. The medical approaches have only limited effects. Recently, two formulations for topical therapy have been evaluated: a product with 40% hydrogen peroxide (HP40) and an aqueous nitric\u2013zinc complex. Based on clinical trials, HP40 seems to be a promising alternative to surgery, in particular for facial lesions.<\/ns4:p>","DOI":"10.12688\/f1000research.18983.1","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T13:25:18Z","timestamp":1566998718000},"page":"1520","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":56,"title":["Recent advances in managing and understanding seborrheic keratosis"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-2913","authenticated-orcid":false,"given":"Uwe","family":"Wollina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"ref-1","first-page":"1119-25","article-title":"Current Understanding of Seborrheic Keratosis: Prevalence, Etiology, Clinical Presentation, Diagnosis, and 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Xiao","year":"2019"},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"957-60","DOI":"10.1111\/ijd.13633","article-title":"A clinical, dermoscopic, and histopathological study of Dermatosis Papulosa Nigra (DPN) - An Indian perspective.","volume":"56","author":"R Bhat","year":"2017","journal-title":"Int J Dermatol."},{"key":"ref-36","doi-asserted-by":"publisher","first-page":"270","DOI":"10.11604\/pamj.2018.30.270.16337","article-title":"The sign of leser-tr\u00e9lat: think in the adenocarcinoma of the lung.","volume":"30","author":"H Asri","year":"2018","journal-title":"Pan Afr Med J."},{"key":"ref-37","first-page":"802-4","article-title":"The sign of Leser-Trelat associated with esophageal carcinoma.","volume":"91","author":"T Chiba","year":"1996","journal-title":"Am J Gastroenterol."},{"key":"ref-38","doi-asserted-by":"publisher","first-page":"52-4","DOI":"10.1111\/j.1365-2230.2008.02923.x","article-title":"The Leser-Tr\u00e9lat sign is associated with nasopharyngeal 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sign of Leser-Trelat.","volume":"3","author":"T Patton","year":"2004","journal-title":"J Drugs Dermatol."},{"key":"ref-43","doi-asserted-by":"crossref","first-page":"475-7","DOI":"10.1097\/CMR.0000000000000477","article-title":"Nivolumab induced inflammation of seborrheic keratoses: a novel cutaneous manifestation in a metastatic melanoma patient.","volume":"28","author":"P Rambhia","year":"2018","journal-title":"Melanoma Res."},{"key":"ref-44","first-page":"16-25","article-title":"A Closer Look at Seborrheic Keratoses: Patient Perspectives, Clinical Relevance, Medical Necessity, and Implications for Management.","volume":"10","author":"J Del Rosso","year":"2017","journal-title":"J Clin Aesthet Dermatol."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"275-7","DOI":"10.1016\/j.clindermatol.2017.09.011","article-title":"The status of the seborrheic keratosis.","volume":"36","author":"A Karadag","year":"2018","journal-title":"Clin Dermatol."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"796-801","DOI":"10.1046\/j.1524-4725.2003.29211.x","article-title":"Frequency of seborrheic keratosis biopsies in the United States: a benchmark of skin lesion care quality and cost effectiveness.","volume":"29","author":"M Duque","year":"2003","journal-title":"Dermatol Surg."},{"key":"ref-47","doi-asserted-by":"publisher","first-page":"108-9","DOI":"10.1001\/2013.jamadermatol.275","article-title":"Effectiveness of cryosurgery vs curettage in the treatment of seborrheic keratoses.","volume":"149","author":"L Wood","year":"2013","journal-title":"JAMA Dermatol."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"477-80","DOI":"10.3109\/09546634.2015.1024597","article-title":"Effectiveness of erbium:YAG laser and cryosurgery in seborrheic keratoses: Randomized, prospective intraindividual comparison study.","volume":"26","author":"M Gurel","year":"2015","journal-title":"J Dermatolog 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Ther."},{"key":"ref-52","doi-asserted-by":"publisher","first-page":"304-6","DOI":"10.5606\/kbbihtisas.2016.04810","article-title":"Treatment of seborrheic keratosis in bilateral external auditory canal using fiber CO2 laser.","volume":"26","author":"R Cevizci","year":"2016","journal-title":"Kulak Burun Bogaz Ihtis Derg."},{"key":"ref-53","doi-asserted-by":"publisher","first-page":"618206","DOI":"10.1155\/2014\/618206","article-title":"Unconventional use of intense pulsed light.","volume":"2014","author":"D Piccolo","year":"2014","journal-title":"Biomed Res Int."},{"key":"ref-54","doi-asserted-by":"publisher","first-page":"321","DOI":"10.4103\/0019-5154.156447","article-title":"Effectiveness of the Pulse Dye Laser Treatment in a Caucasian Women With Dermatosis Papulosa Nigra.","volume":"60","author":"A Karadag","year":"2015","journal-title":"Indian J Dermatol."},{"key":"ref-55","doi-asserted-by":"publisher","first-page":"120-2","DOI":"10.1080\/14764170801950070","article-title":"Treatment of dermatosis papulosa nigra with a 1064 nm Nd:YAG laser: report of two cases.","volume":"10","author":"E Schweiger","year":"2008","journal-title":"J Cosmet Laser Ther."},{"key":"ref-56","doi-asserted-by":"publisher","first-page":"1827-31","DOI":"10.1007\/s10103-018-2459-z","article-title":"Treatment of flat and elevated pigmented disorders with a 755-nm alexandrite picosecond laser: clinical and histological evaluation.","volume":"33","author":"A Alegre-Sanchez","year":"2018","journal-title":"Lasers Med Sci."},{"key":"ref-57","doi-asserted-by":"publisher","first-page":"869-77","DOI":"10.1016\/j.jaad.2018.05.044","article-title":"Safety and efficacy of hydrogen peroxide topical solution, 40% (w\/w), in patients with seborrheic keratoses: Results from 2 identical, randomized, double-blind, placebo-controlled, phase 3 studies 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keratosis.","volume":"7","author":"H Akta\u015f","year":"2016","journal-title":"Indian Dermatol Online J."},{"key":"ref-64","doi-asserted-by":"publisher","first-page":"177-9","DOI":"10.4103\/2229-5178.182354","article-title":"Inverted follicular keratosis successfully treated with imiquimod.","volume":"7","author":"A Karadag","year":"2016","journal-title":"Indian Dermatol Online J."},{"key":"ref-65","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.01.2012.5628","article-title":"Clearance of seborrhoeic keratoses with topical dobesilate.","volume":"2012","author":"P Cuevas","year":"2012","journal-title":"BMJ Case Rep."},{"key":"ref-66","doi-asserted-by":"publisher","first-page":"525-31","DOI":"10.1111\/ics.12080","article-title":"The roles of vitamin D in seborrhoeic keratosis: possible genetic and cellular signalling mechanisms.","volume":"35","author":"K L\u01b0\u01a1ng","year":"2013","journal-title":"Int J Cosmet Sci."},{"key":"ref-67","first-page":"91-108","article-title":"Off-label uses of topical vitamin D in dermatology: a systematic review.","volume":"18","author":"H Wat","year":"2014","journal-title":"J Cutan Med Surg."},{"key":"ref-68","doi-asserted-by":"publisher","first-page":"2270-5","DOI":"10.3889\/oamjms.2018.460","article-title":"Seborrheic Keratoses - The Most Common Benign Skin Tumor of Humans. Clinical presentation and an update on pathogenesis and treatment options.","volume":"6","author":"U Wollina","year":"2018","journal-title":"Open Access Maced J Med Sci."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/8-1520\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-1520\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-1520\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T19:40:27Z","timestamp":1664221227000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/8-1520\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,28]]},"references-count":68,"URL":"https:\/\/doi.org\/10.12688\/f1000research.18983.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.20808.r53126","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.20808.r53125","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.20808.r53124","asserted-by":"subject"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,28]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/8-1520\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.20808.r53124, Iris Zalaudek, Dermatology Clinic, Hospital Maggiore, University of Trieste, Trieste, Italy, 29 Aug 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1520\/v1#referee-response-53124","order":0,"name":"referee-response-53124","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.20808.r53125, Karalikkattil T Ashique, Amanza Health Care, Nahas Skin Clinic, Perinthalmanna, Kerala, India, 29 Aug 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1520\/v1#referee-response-53125","order":1,"name":"referee-response-53125","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.20808.r53126, Lawrence Charles Parish, Department of Dermatology and Cutaneous Biology and the Jefferson Center for International Dermatology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA, 29 Aug 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1520\/v1#referee-response-53126","order":2,"name":"referee-response-53126","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}