{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:31Z","timestamp":1772168971977,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.19056.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000}},{"DOI":"10.12688\/f1000research.19056.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000}},{"DOI":"10.12688\/f1000research.19056.3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000}}],"reference-count":23,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns5:p>Dentists play a fundamental role in the early diagnosis of oral leishmaniasis. Although these lesions are rare at oral mucosa, this is one of the manifestations sites of the disease This study reports seven clinical cases of orofacial mucocutaneous leishmaniasis. All had leishmaniasis diagnosis confirmed by laboratory tests, with orofacial involvement. Five out of the seven cases were males, and in four cases, patients had associated comorbidities. Late diagnosis was observed, resulting in treatment delay and increased hospitalization stay. One patient had severe psychological consequences due to facial deformity. The lack of differential diagnosis due the great variability of clinical presentation of the lesions and frequent unspecific histopathology represent a challenge for the dentist. In two reported cases, there were unspecific biopsy results. This series of cases highlights the importance of a multidisciplinary approach in the diagnosis and treatment of oral and perioral leishmaniasis. Patients with atypical lesions, originating from or living in endemic regions, should be investigated for leishmaniasis. These procedures could avoid delays in diagnosis and decrease the risk of disease dissemination.<\/ns5:p>","DOI":"10.12688\/f1000research.19056.4","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T06:35:34Z","timestamp":1600929334000},"page":"756","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Orofacial manifestations of mucocutaneous leishmaniasis: a case series from Brazil"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1586-7750","authenticated-orcid":false,"given":"Gleicy Gabriela Vit\u00f3ria Spinola Carneiro","family":"Falc\u00e3o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-0002","authenticated-orcid":false,"given":"Liliane","family":"Lins-Kusterer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Miranda","family":"Leite-Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4403-3659","authenticated-orcid":false,"given":"Viviane Almeida","family":"Sarmento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"e70-8","DOI":"10.1111\/odi.12268","article-title":"Mucosal leishmaniasis with primary oral involvement: a case series and a review of the literature.","volume":"21","author":"M Mignogna","year":"2015","journal-title":"Oral Dis."},{"key":"ref-2","article-title":"Control of the leishmaniases.","year":"2010","journal-title":"World Health Organ Tech Rep Ser."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"e1168-71","DOI":"10.1111\/j.1741-2358.2011.00512.x","article-title":"Leishmaniasis with oral mucosa involvement.","volume":"29","author":"A Pellicioli","year":"2012","journal-title":"Gerodontology."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"e20-6","DOI":"10.1016\/j.oooo.2014.09.008","article-title":"Mucocutaneous leishmaniasis must be included in the differential diagnosis of midline destructive disease: two case reports.","volume":"119","author":"R Crovetto-Mart\u00ednez","year":"2015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"396-8","DOI":"10.1016\/j.bjoms.2015.01.021","article-title":"Primary oral leishmaniasis mimicking oral cancer: a case report.","volume":"53","author":"A Celentano","year":"2015","journal-title":"Br J Oral Maxillofac Surg."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"e199-203","DOI":"10.1016\/j.oooo.2016.02.017","article-title":"Mucosal leishmaniasis in Brazilian patients: two case reports with similar clinical presentation and different approaches.","volume":"122","author":"A Cruz","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"739-42","DOI":"10.1111\/1346-8138.12564","article-title":"A case of mucocutaneous leishmaniasis diagnosed by serology.","volume":"41","author":"Y Okumura","year":"2014","journal-title":"J Dermatol."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"54-6","DOI":"10.1016\/j.ijid.2016.08.003","article-title":"Localized mucosal leishmaniasis caused by Leishmania infantum mimicking cancer in the rhinolaryngeal region.","volume":"50","author":"F Cobo","year":"2016","journal-title":"Int J Infect Dis."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"153-63","DOI":"10.1016\/j.inhe.2012.06.004","article-title":"Local or systemic treatment for New World cutaneous leishmaniasis? 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