{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:14Z","timestamp":1772168954957,"version":"3.50.1"},"reference-count":6,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Trichilemmal carcinoma is a rare tumour derived from the outer root sheath of hair follicles\n                    <ns3:sup>.<\/ns3:sup>\n                    \u00a0It can be difficult to distinguish both clinically and histologically from other skin lesions, particularly squamous cell carcinoma.\u00a0 We present the case of a 62-year-old female with a 20-year history of three 1-cm cysts on her scalp.\u00a0 Over a six-month period, a cyst overlying the occiput had become painful and grown in size.\u00a0 The general practitioner and subsequently local emergency department suspected infection.\u00a0 The lesion was incised, and the patient was treated with oral antibiotics.\u00a0 At the time of surgical excision, the lesion measured 3 x 4 cm.\n                  <\/ns3:p>\n                  <ns3:p>Microscopic examination identified rounded dermal lobules of squamous epithelium with trichilemmal keratinization, in keeping with a pre-existing pilar cyst.\u00a0 There were areas with nuclear pleomorphism, mitoses and an infiltrative architecture.\u00a0 A diagnosis of trichilemmal carcinoma arising in a pilar cyst was made.\u00a0 Trichilemmal carcinomas are considered to be a low-grade tumour, but they have the potential to spread to lymph nodes and to metastasise to distant sites in the body, therefore adequate excision and appropriate follow-up are required.<\/ns3:p>","DOI":"10.12688\/f1000research.19157.1","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T05:45:13Z","timestamp":1559627113000},"page":"779","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: A rapidly growing cyst on the scalp"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5050-589X","authenticated-orcid":false,"given":"Emma","family":"Short","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisling","family":"O'Shea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Mukkanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Docjinov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"44-9","DOI":"10.1111\/j.1600-0560.1993.tb01248.x","article-title":"Trichilemmal carcinoma: review of 8 cases.","volume":"20","author":"J Reis","year":"1993","journal-title":"J Cutan Pathol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1207-14","DOI":"10.1002\/1097-0142(19810901)48:5<1207::AID-CNCR2820480526>3.0.CO;2-1","article-title":"Proliferating trichilemmal cyst: a simulant of squamous cell carcinoma.","volume":"48","author":"M Brownstein","year":"1981","journal-title":"Cancer."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"50-3","DOI":"10.7181\/acfs.2017.18.1.50","article-title":"Trichilemmal Carcinoma from Proliferating Trichilemmal Cyst on the Posterior Neck.","volume":"18","author":"U Kim","year":"2017","journal-title":"Arch Craniofac Surg."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"394-406","DOI":"10.1111\/j.1600-0560.1995.tb00754.x","article-title":"Proliferating epithelial cysts. Clinicopathological analysis of 96 cases.","volume":"22","author":"P Sau","year":"1995","journal-title":"J Cutan Pathol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"493-5","DOI":"10.1007\/s12262-015-1427-0","article-title":"Malignant Proliferating Trichilemmal Tumour of the Scalp with Intra-Cranial Extension and Lung Metastasis-a Case Report.","volume":"78","author":"L Lobo","year":"2016","journal-title":"Indian J Surg."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"499-502","DOI":"10.3892\/mco.2013.74","article-title":"Survival study and clinicopathological evaluation of trichilemmal carcinoma.","volume":"1","author":"S Zhuang","year":"2013","journal-title":"Mol Clin Oncol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/8-779\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-779\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-779\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T04:45:24Z","timestamp":1608007524000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/8-779\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,4]]},"references-count":6,"URL":"https:\/\/doi.org\/10.12688\/f1000research.19157.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.20993.r64756","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.20993.r49455","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.20993.r76140","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.20993.r76140","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.20993.r64756","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.20993.r49455","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,4]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/8-779\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.20993.r49455, Laszlo Igali, Norfolk and Norwich University Hospital\u00a0(NNUH), Norwich, UK, 02 Jul 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-779\/v1#referee-response-49455","order":0,"name":"referee-response-49455","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.20993.r64756, Toshitsugu Nakamura, Department of Diagnostic Pathology, Ina Central Hospital, Ina, Japan, 29 Jun 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-779\/v1#referee-response-64756","order":1,"name":"referee-response-64756","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.20993.r76140, Manas Dave, NIHR Academic Clinical Fellow in Oral and Maxillofacial Pathology, The University of Manchester, Manchester, UK, 15 Dec 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-779\/v1#referee-response-76140","order":2,"name":"referee-response-76140","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}