{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:34:05Z","timestamp":1791689645415,"version":"4.3.4"},"reference-count":143,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>This is a selective review of recent publications on dengue clinical features, epidemiology, pathogenesis, and vaccine development placed in a context of observations made over the past half century. Four dengue viruses (DENVs) are transmitted by urban cycle mosquitoes causing diseases whose nature and severity are influenced by interacting factors such as virus, age, immune status of the host, and human genetic variability. A phenomenon that controls the kinetics of DENV infection, antibody-dependent enhancement, best explains the correlation of the vascular permeability syndrome with second heterotypic DENV infections and infection in the presence of passively acquired antibodies. Based on growing evidence<ns4:italic>in vivo<\/ns4:italic>and<ns4:italic>in vitro<\/ns4:italic>, the tissue-damaging DENV non-structural protein 1 (NS1) is responsible for most of the pathophysiological features of severe dengue. This review considers the contribution of hemophagocytic histiocytosis syndrome to cases of severe dengue, the role of movement of humans in dengue epidemiology, and modeling and planning control programs and describes a country-wide survey for dengue infections in Bangladesh and efforts to learn what controls the clinical outcome of dengue infections. Progress and problems with three tetravalent live-attenuated vaccines are reviewed. Several research mysteries remain: why is the risk of severe disease during second heterotypic DENV infection so low, why is the onset of vascular permeability correlated with defervescence, and what are the crucial components of protective immunity?<\/ns4:p>","DOI":"10.12688\/f1000research.19197.1","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T08:45:08Z","timestamp":1564562708000},"page":"1279","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":100,"title":["Recent advances in understanding dengue"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7818-348X","authenticated-orcid":false,"given":"Scott","family":"Halstead","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"402-12","DOI":"10.1016\/j.virol.2006.08.049","article-title":"Potential of ancestral sylvatic dengue-2 viruses to re-emerge.","volume":"358","author":"N Vasilakis","year":"2007","journal-title":"Virology."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"279-295","DOI":"10.1016\/j.meegid.2018.04.032","article-title":"Understanding dengue virus evolution to support epidemic surveillance and counter-measure development.","volume":"62","author":"S Pollett","year":"2018","journal-title":"Infect Genet Evol."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"854-860","DOI":"10.1093\/biosci\/biy119","article-title":"Recent History of Aedes aegypti: Vector Genomics and Epidemiology Records.","volume":"68","author":"J Powell","year":"2018","journal-title":"BioScience."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"854-863","DOI":"10.1038\/s41564-019-0376-y","article-title":"Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus.","volume":"4","author":"M Kraemer","year":"2019","journal-title":"Nat Microbiol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"1562-608","DOI":"10.3390\/v3091562","article-title":"Dengue--quo tu et quo vadis?","volume":"3","author":"R Chen","year":"2011","journal-title":"Viruses."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"1-76","DOI":"10.1016\/S0065-3527(08)00401-6","article-title":"The history and evolution of human dengue emergence.","volume":"72","author":"N Vasilakis","year":"2008","journal-title":"Adv Virus Res."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"504-7","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue.","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1186\/1756-3305-6-351","article-title":"Modelling adult Aedes aegypti and Aedes albopictus survival at different temperatures in laboratory and field settings.","volume":"6","author":"O Brady","year":"2013","journal-title":"Parasit Vectors."},{"key":"ref-9","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7024.1","article-title":"Pathogenesis of Dengue: Dawn of a New Era [version 1; peer review: 3 approved].","volume":"4","author":"S Halstead","year":"2015","journal-title":"F1000Res."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"30-50","DOI":"10.4269\/ajtmh.1952.1.30","article-title":"Research on dengue during World War II.","volume":"1","author":"A Sabin","year":"1952","journal-title":"Am J Trop Med Hyg."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"954-71","DOI":"10.4269\/ajtmh.1969.18.954","article-title":"Dengue and chikungunya virus infection in man in Thailand, 1962-1964. 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