{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:17Z","timestamp":1772168957461,"version":"3.50.1"},"reference-count":12,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R00218\/1"],"award-info":[{"award-number":["MR\/R00218\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000398","name":"Royal College of Radiologists","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001279","name":"Great Ormond Street Hospital Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["15\/190"],"award-info":[{"award-number":["15\/190"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001273","name":"CHILDREN with CANCER UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>This manuscript describes the study of two cases of craniopharyngioma, which have been examined repeatedly over three separate centuries. This includes analysis by Josef Engel in 1839, who sought to uncover the physiological role of the pituitary gland; Jacob Erdheim in 1904, who initially described the disease we now call craniopharyngioma, and recent high resolution MRI and micro-CT imaging and attempted DNA analyses of the tumours. The cases highlight how, rightly or wrongly, our interpretation of data is shaped by the technologies, methodologies and prevailing theories of a given time.<\/ns4:p>","DOI":"10.12688\/f1000research.19626.1","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T05:30:08Z","timestamp":1567143008000},"page":"1544","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Learning from cases: Analysis of two cases of craniopharyngioma from the 19th to the 21st centuries."],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-482X","authenticated-orcid":false,"given":"John R.","family":"Apps","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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Media."},{"key":"ref-10","article-title":"Virtual dissection of 1904 case of craniopharyngioma described by Jacob Erdheim by micro-CT imaging.","author":"J Apps","year":"2019","journal-title":"f1000research.com."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"845-853","DOI":"10.1177\/33.8.3894502","article-title":"Formaldehyde fixation.","volume":"33","author":"C Fox","year":"1985","journal-title":"J Histochem Cytochem."},{"key":"ref-12","first-page":"274-275","article-title":"Fluid Preservation: A comprehensive reference","volume":"27\u201328","author":"J Simmons","year":"2014"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/8-1544\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-1544\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-1544\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T05:05:10Z","timestamp":1580101510000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/8-1544\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,30]]},"references-count":12,"URL":"https:\/\/doi.org\/10.12688\/f1000research.19626.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.21523.r54329","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.21523.r53215","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.21523.r53215","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.21523.r54329","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,30]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/8-1544\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.21523.r53215, Ashley Grossman, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, UK, 02 Sep 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1544\/v1#referee-response-53215","order":0,"name":"referee-response-53215","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.21523.r54329, Ruth Prieto, Jose M. Pascual, Department of Neurosurgery, Puerta de Hierro University Hospital, Madrid, Spain, 27 Jan 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1544\/v1#referee-response-54329","order":1,"name":"referee-response-54329","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"JRA was funded by a Cancer Research UK, Clinical Research Training Fellowship. SCS is supported by a RCUK\/UKRI Innovation Fellowship and Medical Research Council (MRC) Clinical Research Training Fellowship [MR\/R00218\/1]. This award is jointly funded by the Royal College of Radiologists (RCR). NJS is supported by NIHR Senior Investigator award and OJA by NIHR Clinician Scientist fellowship award. NJS receives funding from the Great Ormond Street Hospital Children\u2019s Charity. J.P.M.B. is a Great Ormond Street Hospital for Children\u2019s Charity Principal Investigator. Funding was also received from Children with Cancer UK [15\/190].  This work was undertaken at GOSH\/ICH, UCLH\/UCL who received a proportion of funding from the United Kingdom Department of Health\u2019s NIHR Biomedical Research Centre funding scheme. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}