{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:43Z","timestamp":1772168983824,"version":"3.50.1"},"reference-count":14,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Provincial Secretariat for Higher Education and Scientific Research","award":["114-451-710"],"award-info":[{"award-number":["114-451-710"]}]},{"name":"Serbian Ministry of Education, Science and Technological Development","award":["175037"],"award-info":[{"award-number":["175037"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Sport-related mild traumatic brain injury (TBI) is a serious trauma that could impair brain function of an injured athlete. Treatment solutions for mild TBI typically concentrate on complete rest, while non-traditional therapeutic options remain largely ineffective. Molecular hydrogen (H\n                    <ns4:sub>\n                      <ns4:sup>2<\/ns4:sup>\n                    <\/ns4:sub>\n                    ) is an innovative neuroprotective agent that can easily reach the brain, yet no data are available concerning its value as a first-aid intervention after a mild TBI.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Case report:<\/ns4:bold>\n                    This case report demonstrates the efficacy and safety of a hydrogen-producing dissolving tablet administered buccally during the first 24 hours post-injury in a professional soccer player who suffered a mild TBI. The patient received a formulated dosage of hydrogen every 2 hours, with the first intervention given immediately after an initial examination (~ 15 min after the injury).\n                  <\/ns4:p>\n                  <ns4:p>The overall score for Sport Concussion Assessment Tool 2 (SCAT2), a standardized method of evaluating injured athletes for concussion, increased from 68 points (severe disruption) at baseline to 84 points (mild disruption) at 24-h follow-up. The patient reported no side effects of hydrogen intervention.<\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    This case has demonstrated that intensive consecutive therapy with oral transmucosal hydrogen formulation is a beneficial strategy with regard to the reduction of presence and severity of symptoms of sport-related mild TBI.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.19739.1","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T05:25:08Z","timestamp":1562649908000},"page":"1024","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete"],"prefix":"10.12688","volume":"8","author":[{"given":"Dejan","family":"Javorac","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdemar","family":"Stajer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-2541","authenticated-orcid":false,"given":"Sergej M.","family":"Ostojic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2019,7,9]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"375-378","DOI":"10.1097\/00001199-200609000-00001","article-title":"The epidemiology and impact of traumatic brain injury: a brief overview.","volume":"21","author":"J Langlois","year":"2006","journal-title":"J Head Trauma Rehabil."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"747-755","DOI":"10.1177\/0363546511435626","article-title":"Epidemiology of concussions among United States high school athletes in 20 sports.","volume":"40","author":"M Marar","year":"2012","journal-title":"Am J Sports Med."},{"key":"ref-3","doi-asserted-by":"crossref","article-title":"Sport-Related Traumatic Brain Injury.","author":"M Clark","DOI":"10.1201\/b18959-3"},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"403-408","DOI":"10.1016\/j.ncl.2017.03.011","article-title":"Pathophysiology of Sports-Related Concussion.","volume":"35","author":"K Steenerson","year":"2017","journal-title":"Neurol Clin."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"S359-368","DOI":"10.1016\/j.pmrj.2011.07.018","article-title":"The pathophysiology of concussion.","volume":"3","author":"S Signoretti","year":"2011","journal-title":"PM R."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"79-91","DOI":"10.1080\/1028415X.2016.1236174","article-title":"Supplements, nutrition, and alternative therapies for the treatment of traumatic brain injury.","volume":"21","author":"B Lucke-Wold","year":"2018","journal-title":"Nutr Neurosci."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"324-331","DOI":"10.2174\/1570159X14666160607205417","article-title":"Molecular Hydrogen as a Neuroprotective Agent.","volume":"15","author":"M Iketani","year":"2017","journal-title":"Curr Neuropharmacol."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"51-53","DOI":"10.1016\/j.phrs.2015.02.004","article-title":"Targeting molecular hydrogen to mitochondria: barriers and gateways.","volume":"94","author":"S Ostojic","year":"2015","journal-title":"Pharmacol Res."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"e0212541","DOI":"10.1371\/journal.pone.0212541","article-title":"The Sport Concussion Assessment Tool (SCAT2) for evaluating civilian mild traumatic brain injury. A pilot normative study.","volume":"14","author":"A R\u0103doi","year":"2019","journal-title":"PLoS One."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"132-140","DOI":"10.1080\/23279095.2013.867265","article-title":"Normative values of major SCAT2 and SCAT3 components for a college athlete population.","volume":"22","author":"A Zimmer","year":"2015","journal-title":"Appl Neuropsychol Adult."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"154-163","DOI":"10.1016\/j.freeradbiomed.2015.12.015","article-title":"Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia.","volume":"91","author":"K Imai","year":"2016","journal-title":"Free Radic Biol Med."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1213\/01.ane.0000492562.00670.62","article-title":"Neuroprotective effect of hydrogen gas on brain injury in a rat transient forebrain ischemia model.","volume":"123","author":"G Nagasaki","year":"2016","journal-title":"Anesth Analg."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2045-9912-1-7","article-title":"Hydrogen is neuroprotective against surgically induced brain injury.","volume":"1","author":"J Eckermann","year":"2011","journal-title":"Med Gas Res."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"1-13","DOI":"10.1016\/j.brainres.2016.01.029","article-title":"Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats.","volume":"1637","author":"R Tian","year":"2016","journal-title":"Brain Res."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/8-1024\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-1024\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-1024\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T08:55:12Z","timestamp":1592297712000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/8-1024\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,9]]},"references-count":14,"URL":"https:\/\/doi.org\/10.12688\/f1000research.19739.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.21648.r56420","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.21648.r64103","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.21648.r56420","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.21648.r64103","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,9]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/8-1024\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.21648.r56420, Cheong Hwa Ooi, Advanced Medical And Dental Institute, Universiti Sains Malaysia, Kepala Batas, Malaysia, 29 Nov 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1024\/v1#referee-response-56420","order":0,"name":"referee-response-56420","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.21648.r64103, Katsuhiro Koyama, Shohei Dobashi, Graduate School Department of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan, 16 Jun 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1024\/v1#referee-response-64103","order":1,"name":"referee-response-64103","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"his study is supported by the Serbian Ministry of Education, Science and Technological Development (#175037); the Provincial Secretariat for Higher Education and Scientific Research (#114-451-710); and the Center for Health, Exercise and Sport Sciences, Belgrade. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}