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Despite this burden of disease, it is not currently a reportable disease in the United States. Recent advances in the epidemiology, diagnosis, and management of<ns4:italic>T. vaginalis<\/ns4:italic>infection are described in this article. This includes updated global and U.S. prevalence data in women and men as well as recent epidemiological data in HIV-infected individuals and pregnant women. Advances in molecular diagnostics are also reviewed, as are data from recent clinical trials regarding the treatment of trichomonas in women.<\/ns4:p>","DOI":"10.12688\/f1000research.19972.1","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T13:10:06Z","timestamp":1568985006000},"page":"1666","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":89,"title":["Recent advances in the epidemiology, diagnosis, and management of Trichomonas vaginalis infection"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9362-6234","authenticated-orcid":false,"given":"Olivia T.","family":"Van Gerwen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-3858","authenticated-orcid":false,"given":"Christina A.","family":"Muzny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"548-562P","DOI":"10.2471\/BLT.18.228486","article-title":"Chlamydia, gonorrhoea, trichomoniasis and syphilis: Global prevalence and incidence estimates, 2016.","volume":"97","author":"J Rowley","year":"2019","journal-title":"Bull World Health Organ."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1195-206","DOI":"10.1097\/00006250-200605000-00049","article-title":"ACOG Practice Bulletin. 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Dis."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"1455-8","DOI":"10.1016\/s0022-5347(17)36414-5","article-title":"Natural history of urogenital trichomoniasis in men.","volume":"149","author":"J Krieger","year":"1993","journal-title":"J Urol."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"163-70","DOI":"10.1093\/cid\/ciq074","article-title":"Re-evaluating the treatment of nongonococcal urethritis: emphasizing emerging pathogens--a randomized clinical trial.","volume":"52","author":"J Schwebke","year":"2011","journal-title":"Clin Infect Dis."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"13-22","DOI":"10.1086\/511144","article-title":"Trichomonas vaginalis infection in male sexual partners: implications for diagnosis, treatment, and prevention.","volume":"44","author":"A Se\u00f1a","year":"2007","journal-title":"Clin Infect Dis."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1097\/OLQ.0b013e318264248b","article-title":"Prevalence of urethral Trichomonas vaginalis in black and white men who have sex with men.","volume":"39","author":"C Kelley","year":"2012","journal-title":"Sex Transm Dis."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"1319-26","DOI":"10.1086\/522532","article-title":"The prevalence of Trichomonas vaginalis infection among reproductive-age women in the United States, 2001-2004.","volume":"45","author":"M Sutton","year":"2007","journal-title":"Clin Infect Dis."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"1696-703","DOI":"10.2105\/AJPH.2011.300213","article-title":"Neighborhood social disorganization and the acquisition of trichomoniasis among young adults in the United States.","volume":"101","author":"J Ford","year":"2011","journal-title":"Am J Public Health."},{"key":"ref-18","first-page":"S20-7","article-title":"Examining racial disparities in HIV: lessons from sexually transmitted infections research.","volume":"47 Suppl 1","author":"J Kraut-Becher","year":"2008","journal-title":"J Acquir Immune Defic Syndr."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"927-32","DOI":"10.3201\/eid0706.010603","article-title":"Trichomonas vaginalis, HIV, and African-Americans.","volume":"7","author":"F Sorvillo","year":"2001","journal-title":"Emerg Infect Dis."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"226-9","DOI":"10.1136\/sextrans-2016-052660","article-title":"Trichomonas vaginalis infection is uncommon in the British general population: implications for clinical testing and public health screening.","volume":"94","author":"N Field","year":"2018","journal-title":"Sex Transm Infect."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"1-137","DOI":"10.1016\/j.annemergmed.2015.07.526","article-title":"Sexually transmitted diseases treatment guidelines, 2015.","volume":"64","author":"K Workowski","year":"2015","journal-title":"MMWR Recomm Rep."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"519-22","DOI":"10.1086\/338399","article-title":"Trichomonas vaginalis is associated with pelvic inflammatory disease in women infected with human immunodeficiency virus.","volume":"34","author":"P Moodley","year":"2002","journal-title":"Clin Infect Dis."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"344-52","DOI":"10.1177\/0956462418807115","article-title":"Incidence and predictors of reinfection with trichomoniasis based on nucleic acid amplification testing results in HIV-infected patients.","volume":"30","author":"C Muzny","year":"2019","journal-title":"Int J STD AIDS."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"483-8","DOI":"10.1097\/OLQ.0000000000000479","article-title":"Trichomonas vaginalis Nucleic Acid Amplification Testing at an Urban HIV Clinic.","volume":"43","author":"C Muzny","year":"2016","journal-title":"Sex Transm Dis."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"495-500","DOI":"10.4269\/ajtmh.1998.58.495","article-title":"Risk factors for trichomoniasis among women with human immunodeficiency virus (HIV) infection at a public clinic in Los Angeles County, California: implications for HIV prevention.","volume":"58","author":"F Sorvillo","year":"1998","journal-title":"Am J Trop Med Hyg."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"332-6","DOI":"10.1097\/OLQ.0000000000000756","article-title":"Prevalence and Detection of Trichomonas vaginalis in HIV-Infected Pregnant Women.","volume":"45","author":"C Price","year":"2018","journal-title":"Sex Transm Dis."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"487-93","DOI":"10.1056\/NEJMoa003329","article-title":"Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection.","volume":"345","author":"M Klebanoff","year":"2001","journal-title":"N Engl J Med."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"43-50","DOI":"10.1097\/OGX.0b013e318279fb7d","article-title":"Trichomonas vaginalis vaginitis in obstetrics and gynecology practice: new concepts and controversies.","volume":"68","author":"J Coleman","year":"2013","journal-title":"Obstet Gynecol Surv."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"450-8","DOI":"10.1097\/OLQ.0000000000000460","article-title":"Prevalence of Curable Sexually Transmitted Infections in Pregnant Women in Low- and Middle-Income Countries From 2010 to 2015: A Systematic Review.","volume":"43","author":"D Joseph Davey","year":"2016","journal-title":"Sex Transm Dis."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"e0197696","DOI":"10.1371\/journal.pone.0197696","article-title":"Incidence of sexually transmitted infections during pregnancy.","volume":"13","author":"C Teasdale","year":"2018","journal-title":"PLoS One."},{"key":"ref-31","doi-asserted-by":"publisher","first-page":"2-8","DOI":"10.1097\/OLQ.0000000000000902","article-title":"Unexpected High Rates of Persistent Trichomonas vaginalis Infection in a Retrospective Cohort of Treated Pregnant Women.","volume":"46","author":"G Lazenby","year":"2019","journal-title":"Sex Transm Dis."},{"key":"ref-32","doi-asserted-by":"publisher","first-page":"794-803","DOI":"10.1128\/CMR.17.4.794-803.2004","article-title":"Trichomoniasis.","volume":"17","author":"J Schwebke","year":"2004","journal-title":"Clin Microbiol Rev."},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"434-8","DOI":"10.1136\/sextrans-2013-051057","article-title":"Modern diagnosis of Trichomonas vaginalis infection.","volume":"89","author":"M Hobbs","year":"2013","journal-title":"Sex Transm Infect."},{"key":"ref-34","doi-asserted-by":"publisher","first-page":"35-8","DOI":"10.1155\/2005\/373920","article-title":"The laboratory diagnosis of Trichomonas vaginalis.","volume":"16","author":"G Garber","year":"2005","journal-title":"Can J Infect Dis Med Microbiol."},{"key":"ref-35","doi-asserted-by":"crossref","first-page":"3749-50","DOI":"10.1128\/JCM.37.11.3749-3750.1999","article-title":"Viability of Trichomonas vaginalis in transport medium.","volume":"37","author":"A Beverly","year":"1999","journal-title":"J Clin Microbiol."},{"key":"ref-36","doi-asserted-by":"publisher","first-page":"205-8","DOI":"10.1016\/S1054-139X(97)00214-0","article-title":"Diagnosis of Trichomonas vaginalis in adolescent females: InPouch TV culture versus wet-mount microscopy.","volume":"22","author":"C Ohlemeyer","year":"1998","journal-title":"J Adolesc Health."},{"key":"ref-37","doi-asserted-by":"crossref","first-page":"1275-9","DOI":"10.1128\/JCM.25.7.1275-1279.1987","article-title":"Cell culture compared with broth for detection of Trichomonas vaginalis.","volume":"25","author":"G Garber","year":"1987","journal-title":"J Clin Microbiol."},{"key":"ref-38","doi-asserted-by":"crossref","first-page":"2265-8","DOI":"10.1128\/JCM.30.9.2265-2268.1992","article-title":"The plastic envelope method, a simplified technique for culture diagnosis of trichomoniasis.","volume":"30","author":"C Beal","year":"1992","journal-title":"J Clin Microbiol."},{"key":"ref-39","doi-asserted-by":"publisher","first-page":"3875-6","DOI":"10.1128\/JCM.02006-13","article-title":"Diagnostic rates differ on the basis of the number of read days with the use of the InPouch culture system for Trichomonas vaginalis screening.","volume":"51","author":"C Rivers","year":"2013","journal-title":"J Clin Microbiol."},{"key":"ref-40","first-page":"771-93","article-title":"Trichomonas vaginalis and trichomoniasis","author":"S Hobbs MM","year":"2008"},{"key":"ref-41","doi-asserted-by":"publisher","first-page":"4106-11","DOI":"10.1128\/JCM.01291-11","article-title":"Molecular testing for Trichomonas vaginalis in women: results from a prospective U.S. clinical trial.","volume":"49","author":"J Schwebke","year":"2011","journal-title":"J Clin Microbiol."},{"key":"ref-42","doi-asserted-by":"publisher","first-page":"885-9","DOI":"10.1128\/JCM.02966-13","article-title":"Detection of Trichomonas vaginalis DNA by use of self-obtained vaginal swabs with the BD ProbeTec Qx assay on the BD Viper system.","volume":"52","author":"B van der Pol","year":"2014","journal-title":"J Clin Microbiol."},{"key":"ref-43","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01091-17","article-title":"Clinical Evaluation of the Cepheid Xpert TV Assay for Detection of Trichomonas vaginalis with Prospectively Collected Specimens from Men and Women.","volume":"56","author":"J Schwebke","year":"2018","journal-title":"J Clin Microbiol."},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"188.e1-7","DOI":"10.1016\/j.ajog.2008.10.005","article-title":"Comparison of APTIMA Trichomonas vaginalis transcription-mediated amplification to wet mount microscopy, culture, and polymerase chain reaction for diagnosis of trichomoniasis in men and women.","volume":"200","author":"M Nye","year":"2009","journal-title":"Am J Obstet Gynecol."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1186\/s12879-016-1573-4","article-title":"A novel point-of-care testing strategy for sexually transmitted infections among pregnant women in high-burden settings: results of a feasibility study in Papua New Guinea.","volume":"16","author":"S Badman","year":"2016","journal-title":"BMC Infect Dis."},{"key":"ref-46","doi-asserted-by":"publisher","DOI":"10.16966\/2380-5536.115","article-title":"Point of Care Tests for Diagnosis of Sexually Transmitted Infections: A Landscape Analysis.","volume":"2","author":"R Ridzon","year":"2016","journal-title":"J HIV AIDS."},{"key":"ref-47","doi-asserted-by":"publisher","first-page":"303-6","DOI":"10.1080\/14737159.2017.1282823","article-title":"Clinical performance of the Solana\u00ae Point-of-Care Trichomonas Assay from clinician-collected vaginal swabs and urine specimens from symptomatic and asymptomatic women.","volume":"17","author":"C Gaydos","year":"2017","journal-title":"Expert Rev Mol Diagn."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"369-73","DOI":"10.1097\/OLQ.0000000000000447","article-title":"Rapid Diagnosis of Trichomonas vaginalis by Testing Vaginal Swabs in an Isothermal Helicase-Dependent AmpliVue Assay.","volume":"43","author":"C Gaydos","year":"2016","journal-title":"Sex Transm Dis."},{"key":"ref-49","doi-asserted-by":"publisher","first-page":"49-53","DOI":"10.1016\/j.diagmicrobio.2012.05.003","article-title":"Performance of rapid immunochromatographic assay in the diagnosis of Trichomoniasis vaginalis.","volume":"74","author":"M Hegazy","year":"2012","journal-title":"Diagn Microbiol Infect Dis."},{"key":"ref-50","doi-asserted-by":"publisher","first-page":"251-6","DOI":"10.1177\/0956462414534833","article-title":"Microscopy outperformed in a comparison of five methods for detecting Trichomonas vaginalis in symptomatic women.","volume":"26","author":"B Nathan","year":"2015","journal-title":"Int J STD AIDS."},{"key":"ref-51","doi-asserted-by":"publisher","first-page":"1002-3","DOI":"10.1016\/j.ajem.2018.10.022","article-title":"The OSOM\u00ae Trichomonas Test is unable to accurately diagnose Trichomonas vaginalis from urine in men.","volume":"37","author":"J Sheele","year":"2019","journal-title":"Am J Emerg Med."},{"key":"ref-52","doi-asserted-by":"publisher","first-page":"e0196209","DOI":"10.1371\/journal.pone.0196209","article-title":"Beyond syndromic management: Opportunities for diagnosis-based treatment of sexually transmitted infections in low- and middle-income countries.","volume":"13","author":"N Garrett","year":"2018","journal-title":"PLoS One."},{"key":"ref-53","doi-asserted-by":"publisher","first-page":"456-8","DOI":"10.1136\/sti.47.6.456","article-title":"Trichomonal vaginitis treated with one dose of metronidazole.","volume":"47","author":"G Csonka","year":"1971","journal-title":"Br J Vener Dis."},{"key":"ref-54","doi-asserted-by":"publisher","first-page":"65-8","DOI":"10.1136\/sti.48.1.65","article-title":"Treatment of trichomonal vaginitis with a single oral dose of metronidazole.","volume":"48","author":"K Woodcock","year":"1972","journal-title":"Br J Vener Dis."},{"key":"ref-55","doi-asserted-by":"publisher","first-page":"354-6","DOI":"10.1136\/sti.55.5.354","article-title":"Double-blind comparison of a single dose and a five-day course of metronidazole in the treatment of trichomoniasis.","volume":"55","author":"R Thin","year":"1979","journal-title":"Br J Vener Dis."},{"key":"ref-56","first-page":"743-5","article-title":"Treatment of vaginal trichomoniasis. Single, 2-gram dose of metronidazole as compared with a seven-day course.","volume":"27","author":"J Aubert","year":"1982","journal-title":"J Reprod Med."},{"key":"ref-57","doi-asserted-by":"publisher","first-page":"29-34","DOI":"10.1097\/OLQ.0000000000000537","article-title":"Single-Dose Compared With Multidose Metronidazole for the Treatment of Trichomoniasis in Women: A Meta-Analysis.","volume":"44","author":"K Howe","year":"2017","journal-title":"Sex Transm Dis."},{"key":"ref-58","doi-asserted-by":"publisher","first-page":"565-71","DOI":"10.1097\/QAI.0b013e3181eda955","article-title":"A randomized treatment trial: single versus 7-day dose of metronidazole for the treatment of Trichomonas vaginalis among HIV-infected women.","volume":"55","author":"P Kissinger","year":"2010","journal-title":"J Acquir Immune Defic Syndr."},{"key":"ref-59","doi-asserted-by":"publisher","first-page":"1251-9","DOI":"10.1016\/S1473-3099(18)30423-7","article-title":"Single-dose versus 7-day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial.","volume":"18","author":"P Kissinger","year":"2018","journal-title":"Lancet Infect Dis."},{"key":"ref-60","doi-asserted-by":"publisher","first-page":"e57-e59","DOI":"10.1097\/OLQ.0000000000000959","article-title":"Is It Time to Stop Using Single-dose Oral Metronidazole for the Treatment of Trichomoniasis in Women?","volume":"46","author":"C Muzny","year":"2019","journal-title":"Sex Transm Dis."},{"key":"ref-61","doi-asserted-by":"publisher","first-page":"170-9","DOI":"10.2174\/157488631002150515124548","article-title":"The use of metronidazole during pregnancy: A review of evidence.","volume":"10","author":"O Sheehy","year":"2015","journal-title":"Curr Drug Saf."},{"key":"ref-62","doi-asserted-by":"publisher","first-page":"9-11","DOI":"10.1097\/00007435-198701000-00002","article-title":"Urethral trichomoniasis in men.","volume":"14","author":"A Latif","year":"1987","journal-title":"Sex Transm Dis."},{"key":"ref-63","first-page":"18-21","article-title":"[Clinical and microbiological efficacy of metronidazole and ornidazole in the treatment of urogenital trichomoniasis in men].","volume":"51","author":"A Khrianin","year":"2006","journal-title":"Antibiot Khimioter."},{"key":"ref-64","doi-asserted-by":"publisher","first-page":"812-4","DOI":"10.1128\/aac.28.6.812","article-title":"Concentrations of metronidazole and tinidazole in male genital tissues.","volume":"28","author":"J Viitanen","year":"1985","journal-title":"Antimicrob Agents Chemother."},{"key":"ref-65","doi-asserted-by":"publisher","first-page":"77-80","DOI":"10.1136\/sti.54.2.77","article-title":"Secnidazole. A 5-nitroimidazole derivative with a long half-life.","volume":"54","author":"D Videau","year":"1978","journal-title":"Br J Vener Dis."},{"key":"ref-66","doi-asserted-by":"publisher","first-page":"193-4","DOI":"10.1136\/sti.53.3.193","article-title":"Comparison of ornidazole and tinidazole in single-dose treatment of trichomoniasis in women.","volume":"53","author":"L Hillstr\u00f6m","year":"1977","journal-title":"Br J Vener Dis."},{"key":"ref-67","doi-asserted-by":"publisher","first-page":"1341-6","DOI":"10.1086\/323034","article-title":"Tinidazole therapy for metronidazole-resistant vaginal trichomoniasis.","volume":"33","author":"J Sobel","year":"2001","journal-title":"Clin Infect Dis."},{"key":"ref-68","doi-asserted-by":"publisher","first-page":"e1-e2","DOI":"10.1097\/OLQ.0000000000000903","article-title":"Metronidazole-Resistant Trichomoniasis: Beneficial Pharmacodynamic Relationship With High-Dose Oral Tinidazole and Vaginal Paromomycin Combination Therapy.","volume":"46","author":"M Henien","year":"2019","journal-title":"Sex Transm Dis."},{"key":"ref-69","doi-asserted-by":"publisher","first-page":"962-3","DOI":"10.1097\/OLQ.0b013e31822037e4","article-title":"Resistant trichomoniasis: successful treatment with combination therapy.","volume":"38","author":"P Nyirjesy","year":"2011","journal-title":"Sex Transm Dis."},{"key":"ref-70","doi-asserted-by":"publisher","first-page":"653-60","DOI":"10.1016\/j.trstmh.2008.09.008","article-title":"Paromomycin.","volume":"103","author":"R Davidson","year":"2009","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-71","doi-asserted-by":"publisher","first-page":"986-8","DOI":"10.1086\/513951","article-title":"Difficult-to-treat trichomoniasis: results with paromomycin cream.","volume":"26","author":"P Nyirjesy","year":"1998","journal-title":"Clin Infect Dis.."},{"key":"ref-72","doi-asserted-by":"publisher","first-page":"934-6","DOI":"10.1016\/s0002-9378(96)70329-0","article-title":"An incremental dosing protocol for women with severe vaginal trichomoniasis and adverse reaction to metronidazole.","volume":"174","author":"M Pearlman","year":"1996","journal-title":"Am J Obstet Gynecol."},{"key":"ref-73","doi-asserted-by":"publisher","first-page":"66-9","DOI":"10.2500\/ar.2014.5.0080","article-title":"Modified oral metronidazole desensitization protocol.","volume":"5","author":"S Gendelman","year":"2014","journal-title":"Allergy Rhinol (Providence)."},{"key":"ref-74","doi-asserted-by":"publisher","first-page":"423-5","DOI":"10.1136\/sextrans-2012-050893","article-title":"The clinical spectrum of Trichomonas vaginalis infection and challenges to management.","volume":"89","author":"C Muzny","year":"2013","journal-title":"Sex Transm Infect."},{"key":"ref-75","doi-asserted-by":"publisher","first-page":"389-91","DOI":"10.1071\/SH11114","article-title":"Symptomatic Trichomonas vaginalis infection in the setting of severe nitroimidazole allergy: successful treatment with boric acid.","volume":"9","author":"C Muzny","year":"2012","journal-title":"Sex Health."},{"key":"ref-76","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/OLQ.0000000000000559","article-title":"Trichomonas vaginalis Treated With Boric Acid in a Metronidazole Allergic Female.","volume":"44","author":"K Backus","year":"2017","journal-title":"Sex Transm Dis."},{"key":"ref-77","doi-asserted-by":"crossref","first-page":"397-8","DOI":"10.1097\/OLQ.0b013e3181dd27ba","article-title":"Should expedited partner treatment for women with Trichomonas vaginalis be recommended?","volume":"37","author":"P Kissinger","year":"2010","journal-title":"Sex Transm Dis."},{"key":"ref-78","doi-asserted-by":"publisher","first-page":"S63-75","DOI":"10.1097\/OLQ.0000000000000399","article-title":"The Expedited Partner Therapy Continuum: A Conceptual Framework to Guide Programmatic Efforts to Increase Partner Treatment.","volume":"43","author":"J Schillinger","year":"2016","journal-title":"Sex 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Van Gerwen is currently supported by grant T32 HS013852 from the Agency for Healthcare Research and Quality. Christina A. Muzny is currently supported by the National Institute of Allergy and Infectious Diseases (grant K23AI106957-01A1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}