{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:57Z","timestamp":1772168997338,"version":"3.50.1"},"reference-count":18,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T00:00:00Z","timestamp":1384473600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Purpose:<\/ns4:bold>\n                    To present a case who developed Bell\u2019s palsy while using interferon alpha 2a for Beh\u00e7et uveitis.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    A patient with Beh\u00e7et disease presented with decreased vision in his right eye. Ophthalmic examination, fundus fluorescein angiography and optical coherence tomography were performed. After developing facial paralysis while on interferon therapy, the patient was referred to our neurology service for differential diagnosis and treatment.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    Examination of right eye revealed panuveitis with branch retinal vein occlusion, so high dose steroids were prescribed. In three days there was no improvement in terms of vitreous inflammation and so steroids were replaced with interferon. At the seventh month, patient experienced a facial paralysis. After eliminating other causes, including viral infections, trauma, cold exposure and neurological evaluation with cranial MRI, the patient was diagnosed to have Bell\u2019s palsy by a neurologist. Interferon was replaced with mycophenolate mofetil and the Bell\u2019s palsy was treated with oral steroids.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion:<\/ns4:bold>\n                    It is important to be alert to both common and rare complications while treating with interferon.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.2-245.v1","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T04:52:13Z","timestamp":1384491133000},"page":"245","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Bell\u2019s palsy during interferon alpha 2a treatment in a case with Beh\u00e7et uveitis"],"prefix":"10.12688","volume":"2","author":[{"given":"Fatime Nil\u00fcfer","family":"Yal\u00e7inda\u011f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Alay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"423-31","DOI":"10.1136\/bjo.87.4.423","article-title":"Human recombinant interferon alfa-2a for the treatment of Beh\u00e7et's disease with sight threatening posterior or panuveitis.","volume":"87","author":"I K\u00f6tter","year":"2003","journal-title":"Br J Ophthalmol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"439-43","DOI":"10.1089\/jop.2011.0238","article-title":"Results of Interferon Alpha-2a Therapy in Patients with Behcet's Disease.","volume":"28","author":"F Yal\u00e7inda\u011f","year":"2012","journal-title":"J Ocul Pharmacol Ther."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"110-2","DOI":"10.1046\/j.1365-2516.2000.00391.x","article-title":"Bell\u2019s palsy during interferon therapy for chronic hepatitis C infection in patients with haemorrhagic disorders.","volume":"6","author":"O Ogundipe","year":"2000","journal-title":"Haemophilia."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"174-6","DOI":"10.1089\/jir.2005.25.174","article-title":"Bell\u2019s palsy associated with IFN-alpha and ribavirin therapy for hepatitis C virus infection.","volume":"25","author":"M Hoare","year":"2005","journal-title":"J Interferon Cytokine Res."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"152-3","DOI":"10.1097\/RHU.0b013e31821557e7","article-title":"Interferon-\u03b1 induced lupus in a patient with chronic hepatitis C virus.","volume":"17","author":"R Rizvi","year":"2011","journal-title":"J Clin 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Gastroenterol."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"240-3","DOI":"10.2298\/SARH1004240H","article-title":"Late onset of severe thrombocytopenia during interferon treatment for chronic hepatitis C infection--case report.","volume":"138","author":"J Hajder","year":"2010","journal-title":"Srp Arh Celok Lek."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"316-8","DOI":"10.1016\/j.lpm.2010.10.024","article-title":"Complete atrio-ventricular block: a rare complication of interferon alpha therapy.","volume":"40","author":"N Roche","year":"2011","journal-title":"Presse Med."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"749-50","DOI":"10.1016\/j.eimc.2010.02.019","article-title":"Pericardial effusion associated to interferon in an immunocompetent patient.","volume":"28","author":"J Velasco","year":"2010","journal-title":"Enferm Infecc Microbiol Clin."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"942-9","DOI":"10.1016\/j.biopsych.2010.04.019","article-title":"Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol.","volume":"68","author":"C Raison","year":"2010","journal-title":"Biol Psychiatry."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"299-304","DOI":"10.1076\/ocii.10.4.299.15588","article-title":"Multiple sclerosis-like disease secondary to alpha interferon.","volume":"10","author":"T Matsuo","year":"2002","journal-title":"Ocul Immunol Inflamm."},{"key":"ref-14","first-page":"251-3","article-title":"Anterior ischemic optic neuropathy in a patient with hepatitis C treated with interferon-alpha and ribavirin.","volume":"13","author":"B Knyazer","year":"2011","journal-title":"Isr Med Assoc J."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"318-21","DOI":"10.3748\/wjg.14.318","article-title":"Acute inflammatory demyelinating polyneuropathy associated with pegylated interferon alpha 2a therapy for chronic hepatitis C virus infection.","volume":"14","author":"V Khiani","year":"2008","journal-title":"World J Gastroenterol."},{"key":"ref-16","first-page":"97-9","article-title":"Axonal neuropathy and hearing loss associated with alpha interferon treatment in chronic hepatitis B: a case report.","volume":"15","author":"A Tunca","year":"2004","journal-title":"Turk J Gastroenterol."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"637-40","DOI":"10.2169\/internalmedicine.33.637","article-title":"Abducent nerve paralysis during interferon alpha-2a therapy in a case of chronic active hepatitis C.","volume":"33","author":"Y Fukumoto","year":"1994","journal-title":"Intern Med."},{"key":"ref-18","first-page":"111-4","article-title":"Oculomotor nerve paralysis induced by alpha II-interferon.","volume":"90","author":"G Bauherz","year":"1990","journal-title":"Acta Neurol Belg."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/2-245\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/2-245\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/2-245\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T08:30:30Z","timestamp":1543825830000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/2-245\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,15]]},"references-count":18,"URL":"https:\/\/doi.org\/10.12688\/f1000research.2-245.v1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.2863.r3445","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.2863.r2953","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.2863.r2953","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.2863.r3445","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,15]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/2-245\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.2863.r2953, Erkan Alpsoy, Department of Dermatology and Venerology, Faculty of Medicine, Akdeniz University, Antalya, Turkey, 14 Jan 2014, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/2-245\/v1#referee-response-2953","order":0,"name":"referee-response-2953","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.2863.r3445, Sumru Onal, Uveitis Service, Department of Ophthalmology, Marmara University School of Medicine, Uskudar, Istanbul, Turkey, 10 Feb 2014, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/2-245\/v1#referee-response-3445","order":1,"name":"referee-response-3445","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}