{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:41:03Z","timestamp":1793932863929,"version":"4.8.0"},"reference-count":42,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council"},{"DOI":"10.13039\/501100000291","name":"Kidney Research UK","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000291","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Nephrotic Syndrome Trust"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Podocytes, or glomerular epithelial cells, form the final layer in the glomerular capillary wall of the kidney. Along with the glomerular basement membrane and glomerular endothelial cells, they make up the glomerular filtration barrier which allows the passage of water and small molecules and, in healthy individuals, prevents the passage of albumin and other key proteins. The podocyte is a specialised and terminally differentiated cell with a specific cell morphology that is largely dependent on a highly dynamic underlying cytoskeletal network and that is essential for maintaining glomerular function and integrity in healthy kidneys. The RhoGTPases (RhoA, Rac1 and Cdc42), which act as molecular switches that regulate actin dynamics, are known to play a crucial role in maintaining the cytoskeletal and molecular integrity of the podocyte foot processes in a dynamic manner. Recently, novel protein interaction networks that regulate the RhoGTPases in the podocyte and that are altered by disease have been discovered. This review will discuss these networks and their potential as novel therapeutic targets in nephrotic syndrome. It will also discuss the evidence that they are direct targets for (a) steroids, the first-line agents for the treatment of nephrotic syndrome, and (b) certain kinase inhibitors used in cancer treatment, leading to nephrotoxicity.<\/ns4:p>","DOI":"10.12688\/f1000research.20105.1","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T07:30:08Z","timestamp":1572852608000},"page":"1847","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Podocyte RhoGTPases: new therapeutic targets for nephrotic syndrome?"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9808-4518","authenticated-orcid":false,"given":"Moin A.","family":"Saleem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2148-6658","authenticated-orcid":false,"given":"Gavin 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.22073.r55572, Shreeram Akilesh, Kidney Research Institute, University of Washington, Seattle, Washington, USA, 04 Nov 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1847\/v1#referee-response-55572","order":0,"name":"referee-response-55572","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.22073.r55573, Robert Spurney, Gentzon Hall, Division of Nephrology, Department of Medicine, Duke University Health System, Durham, NC, USA, 04 Nov 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1847\/v1#referee-response-55573","order":1,"name":"referee-response-55573","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Work in the authors\u2019 laboratory is sponsored by the Medical Research Council, Kidney Research UK and the Nephrotic Syndrome Trust. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}