{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:37Z","timestamp":1772168977455,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.20420.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000}}],"reference-count":15,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Ovarian borderline serous tumors present with peritoneal involvement in 20% of cases, either as non-invasive or invasive implants, the latter also known as extraovarian low-grade serous carcinoma. The coexistence of high-grade serous carcinoma is rare, suggesting a synchronous neoplasia with a distinct and independent tumor biology and behavior. We aim to describe a case of a synchronous ovary-peritoneum neoplasia: serous borderline tumor and primary peritoneal high-grade serous carcinoma. A discussion and literature review concerning the optimal diagnostic and therapeutic approach is provided.<\/ns4:p>","DOI":"10.12688\/f1000research.20420.2","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T10:21:12Z","timestamp":1573208472000},"page":"1630","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Borderline tumor and primary peritoneal carcinoma - a rare synchronism"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5974-9671","authenticated-orcid":false,"given":"Mariana","family":"Rei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Raposo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds","family":"S\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"ref-1","first-page":"57-62","article-title":"(Chapter 1: Tumours of the ovary)","author":"J Prat","year":"2014"},{"key":"ref-2","first-page":"151-160","article-title":"Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.","volume":"27","author":"R Kurman","year":"2008","journal-title":"Int J Gynecol Pathol."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"700-10","DOI":"10.1086\/318787","article-title":"Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer.","volume":"68","author":"H Risch","year":"2001","journal-title":"Am J Hum Genet."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"433-438","DOI":"10.1016\/j.ygyno.2016.08.320","article-title":"Low-grade serous ovarian cancer: A review.","volume":"143","author":"A Kaldawy","year":"2016","journal-title":"Gynecol Oncol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"733-47","DOI":"10.1016\/j.ajpath.2015.11.011","article-title":"The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded.","volume":"186","author":"R Kurman","year":"2016","journal-title":"Am J Pathol."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"8794-8801","DOI":"10.1200\/JCO.2005.01.7632","article-title":"Logistic regression model to distinguish between the benign and malignant adnexal mass before surgery: a multicenter study by the International Ovarian Tumor Analysis Group.","volume":"23","author":"D Timmerman","year":"2005","journal-title":"J Clin Oncol."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"g5920","DOI":"10.1136\/bmj.g5920","article-title":"Evaluating the risk of ovarian cancer before surgery using the ADNEX model to differentiate between benign, borderline, early and advanced stage invasive, and secondary metastatic tumours: prospective multicentre diagnostic study.","volume":"349","author":"B Van Calster","year":"2014","journal-title":"BMJ."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"784-792","DOI":"10.1002\/uog.17225","article-title":"Estimating risk of malignancy in adnexal masses: external validation of the ADNEX model and comparison with other frequently used ultrasound methods.","volume":"49","author":"E Meys","year":"2017","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1757-2215-7-49","article-title":"Preoperative HE4 and ROMA values do not improve the CA125 diagnostic value for borderline tumors of the ovary (BOT) - 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The reviewers\u2019 comments were highly appreciated and were thoroughly taken into consideration.1.Additional clinical details were provided in order to demonstrate the pathological diagnosis in which the case relies on, namely&nbsp;regarding the morphological and immunohistochemical features and a new set of histologic images.2.In the last paragraph of the Discussion section we display&nbsp;a final summary of the main findings and their implications for the clinical practice, while trying to be clear and concise.Thank you in advance for your encouraging and inspiring review. We hope that the manuscript is now appropriate for being considered for publication. Please do not hesitate to contact me if any further information is needed.&nbsp;Kind regards,Mariana Rei, MD","URL":"https:\/\/f1000research.com\/articles\/8-1630\/v2#referee-comment-5013","order":2,"name":"referee-comment-5013","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}