{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:30:24Z","timestamp":1790188224579,"version":"4.1.0"},"reference-count":10,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. During recovery, diameter and colour intensity of the cutaneous lesions increased, but after some weeks, lesions had a self-limited resolution without any treatment. Based on clinical and laboratory findings, a diagnosis of acute hemorrhagic edema of infancy (AHEI) was made.\u00a0 AHEI is a rare cutaneous leukocytoclastic vasculitis that usually affects children aged between 4 and 24 months. Etiology is unknown but almost of 75% of cases are preceded by infectious episodes, vaccinations or use of medications. In contrast to the dramatic cutaneous eruption, clinical conditions are usually optimal. Classically, AHEI is characterized by a triad of symptoms: fever, edema and purpura. Skin lesions are erythematous, annular, medallion-like, purpuric plaques that have a rapid onset and appear on the face and extremities, sparing trunk and mucosal membranes. Initially interpreted as a variant of Henoch-Sch\u00f6nlein purpura, now it is considered a distinct disease. In the majority of cases the disease is benign and self-limited without a visceral involvement, so a conservative approach is most often chosen.<\/ns4:p>","DOI":"10.12688\/f1000research.20645.1","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T10:50:06Z","timestamp":1571309406000},"page":"1771","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura)\u00a0\u2013 a dramatic presentation for a benign disease"],"prefix":"10.12688","volume":"8","author":[{"given":"Elena","family":"Carboni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Scavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Stefanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9027-6921","authenticated-orcid":false,"given":"Valentina","family":"Talarico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Zampogna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Concetta","family":"Galati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Raiola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"18-9","DOI":"10.1001\/jama.1913.04350010020008","article-title":"Purpura, urticaria and angioneurotic edema of the hands and feet in a nursing baby.","volume":"61","author":"I Snow","year":"1913","journal-title":"JAMA."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"684-695","DOI":"10.1016\/j.jaad.2008.06.005","article-title":"Acute hemorrhagic edema of young children (cockade purpura and edema): a case series and systematic review.","volume":"59","author":"E Fiore","year":"2008","journal-title":"J Am Acad 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Miorin","year":"2002","journal-title":"Medico e Bambino pagine elettroniche."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"197-9","DOI":"10.2147\/CCID.S51525","article-title":"Acute hemorrhagic edema of infancy: a worrisome presentation, but benign course.","volume":"6","author":"A Alhammadi","year":"2013","journal-title":"Clin Cosmet Investig Dermatol."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"114-7","DOI":"10.1111\/j.1651-2227.1996.tb13904.x","article-title":"Acute haemorrhagic oedema of infancy, a benign variant of leucocytoclastic vasculitis.","volume":"85","author":"I Krause","year":"1996","journal-title":"Acta Paediatr."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"e149-52","DOI":"10.1111\/pde.12004","article-title":"Acute hemorrhagic edema of infancy: a troubling cutaneous presentation with a self-limiting course.","volume":"30","author":"F Savino","year":"2013","journal-title":"Pediatr Dermatol."},{"key":"ref-10","article-title":"Edema acuto emorragico della prima infanzia (porpora di seidlmayer).","volume":"12","author":"A Tagliabue","year":"2009","journal-title":"Medico e Bambino pagine elettroniche."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/8-1771\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-1771\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/8-1771\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T05:05:11Z","timestamp":1577423111000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/8-1771\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,17]]},"references-count":10,"URL":"https:\/\/doi.org\/10.12688\/f1000research.20645.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.22706.r57605","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.22706.r57576","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.22706.r57576","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.22706.r57605","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,17]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/8-1771\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.22706.r57576, Mario Bianchetti, Universit\u00e0 della Svizzera italiana, Lugano, Switzerland, 09 Dec 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1771\/v1#referee-response-57576","order":0,"name":"referee-response-57576","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.22706.r57605, Antonio Francesco Urbino, Department\u00a0of\u00a0Pediatric Emergency, Regina Margherita Children's Hospital, A.O.U. Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy, 27 Dec 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-1771\/v1#referee-response-57605","order":1,"name":"referee-response-57605","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}