{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:36:08Z","timestamp":1778837768625,"version":"3.51.4"},"reference-count":149,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Perinatal brain injury is a major cause of neurological disability in both premature and term infants. In this review, we summarize the evidence behind some established neuroprotective practices such as administration of antenatal steroids, intrapartum magnesium for preterm delivery, and therapeutic hypothermia. In addition, we examine emerging practices such as delayed cord clamping, postnatal magnesium administration, recombinant erythropoietin, and non-steroidal anti-inflammatory agents and finally inform the reader about novel interventions, some of which are currently in trials, such as xenon, melatonin, topiramate, allopurinol, creatine, and autologous cord cell therapy.<\/ns4:p>","DOI":"10.12688\/f1000research.20722.1","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T11:20:07Z","timestamp":1575026407000},"page":"2031","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Recent advances in perinatal neuroprotection"],"prefix":"10.12688","volume":"8","author":[{"given":"Samata","family":"Singhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3701-6028","authenticated-orcid":false,"given":"Michael","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"56-64","DOI":"10.1002\/1098-2779(200102)7:1<56::AID-MRDD1008>3.0.CO;2-A","article-title":"Perinatal brain injury: from pathogenesis to neuroprotection.","volume":"7","author":"J Volpe","year":"2001","journal-title":"Ment Retard Dev Disabil Res Rev."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"2162-72","DOI":"10.1016\/S0140-6736(12)60820-4","article-title":"National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications.","volume":"379","author":"H Blencowe","year":"2012","journal-title":"Lancet."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"334-40","DOI":"10.1111\/j.1469-8749.2008.02047.x","article-title":"Prevalence, type, distribution, and severity of cerebral palsy in relation to gestational age: a meta-analytic review.","volume":"50","author":"E Himpens","year":"2008","journal-title":"Dev Med Child Neurol."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"F159-64","DOI":"10.1136\/fn.85.3.f159","article-title":"Outcome at 14 years of extremely low birthweight infants: a regional study.","volume":"85","author":"L Doyle","year":"2001","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"CD004454","DOI":"10.1002\/14651858.CD004454.pub3","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.","volume":"3","author":"D Roberts","year":"2017","journal-title":"Cochrane Database Syst Rev."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"1297-305","DOI":"10.1172\/JCI112103","article-title":"Postnatal development of alveoli. 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