{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:47:44Z","timestamp":1790786864170,"version":"4.1.0"},"reference-count":50,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Microvillus inclusion disease (MVID) is a rare congenital severe malabsorptive and secretory diarrheal\u00a0disease characterized by blunted or absent microvilli with accumulation of secretory granules and inclusion bodies in enterocytes. The typical clinical presentation of the disease is severe chronic diarrhea that rapidly leads to dehydration and metabolic acidosis. Despite significant advances in our understanding of the causative factors, to date, no curative therapy for MVID and associated diarrhea exists. Prognosis mainly relies on life-long total parenteral nutrition (TPN) and eventual small bowel and\/or liver transplantation. Both TPN and intestinal transplantation are challenging and present with many side effects. A breakthrough in the understanding of MVID emanated from seminal findings revealing mutations in<ns4:italic>MYO5B<\/ns4:italic>as a cause for MVID. During the last decade, many studies have thus utilized cell lines and animal models with knockdown of<ns4:italic>MYO5B<\/ns4:italic>to closely recapitulate the human disease and investigate potential therapeutic options in disease management. We will review the most recent advances made in the research pertaining to MVID. We will also highlight the tools and models developed that can be utilized for basic and applied research to increase our understanding of MVID and develop novel and effective targeted therapies.<\/ns4:p>","DOI":"10.12688\/f1000research.20762.1","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T15:15:08Z","timestamp":1575558908000},"page":"2061","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Recent advances in understanding and managing malabsorption: focus on microvillus inclusion disease"],"prefix":"10.12688","volume":"8","author":[{"given":"Dulari","family":"Jayawardena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waddah A.","family":"Alrefai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep 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Shanthi Srinivasan, Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA, USA, 05 Dec 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-2061\/v1#referee-response-57208","order":2,"name":"referee-response-57208","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.22836.r57206, Sabine Middendorp, Department of Paediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands, 05 Dec 2019, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/8-2061\/v1#referee-response-57206","order":3,"name":"referee-response-57206","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}