{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:10:04Z","timestamp":1792509004710,"version":"4.5.0"},"reference-count":32,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Obesity and osteoporosis are both common conditions with high rates of morbidity and mortality. There is a relationship between obesity and bone. There are multiple factors that influence the risk of fracture, including the quality of bone, the risk of falls, and the padding around the bone. These multiple factors partly explain the finding that obesity protects against fractures in some sites while increasing the risk in other parts of the body. While it is well known that increased weight builds bone, there are several mechanisms related to the obese state that make the bone more fragile. These include the increased production of bone marrow fat cells at the expense of bone-forming osteoblasts, an increase in inflammatory cytokines leading to the activation of bone-resorbing osteoclasts, mutations in the<ns4:italic>FTO<\/ns4:italic>gene, and obesity-induced increased osteoblast senescence. Surprisingly, the relationship between bone and obesity is not unidirectional; there is now evidence that osteocytes are able to regulate body weight by acting as weighing machines.<\/ns4:p>","DOI":"10.12688\/f1000research.20875.1","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T11:25:07Z","timestamp":1599650707000},"page":"1111","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["Obesity and Bone"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8517-2076","authenticated-orcid":false,"given":"Joseph","family":"Proietto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.21037\/atm.2017.03.107","article-title":"Morbidity and mortality associated with obesity.","volume":"5","author":"M Abdelaal","year":"2017","journal-title":"Ann Transl Med."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1174-81","DOI":"10.1210\/jc.2009-0852","article-title":"Effect of osteoporosis treatment on mortality: A meta-analysis.","volume":"95","author":"M Bolland","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"447-55","DOI":"10.1007\/s00198-004-1762-7","article-title":"Quality of life in patients with osteoporosis.","volume":"16","author":"P Lips","year":"2005","journal-title":"Osteoporos Int."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"361","DOI":"10.12968\/bjca.2010.5.8.66243","article-title":"Is \u2018obese\u2019 the new \u2018big-boned\u2019?","volume":"5","author":"V Stuart-Jones","year":"2010","journal-title":"British Journal of Cardiac Nursing."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"51-60","DOI":"10.1016\/j.arr.2014.02.007","article-title":"Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels.","volume":"15","author":"J Ilich","year":"2014","journal-title":"Ageing Res Rev."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"1022-30","DOI":"10.1002\/jbmr.3984","article-title":"Preschool Obesity Is Associated With an Increased Risk of Childhood Fracture: A Longitudinal Cohort Study of 466,997 Children and Up to 11 Years of Follow-up in Catalonia, Spain.","volume":"35","author":"J Lane","year":"2020","journal-title":"J Bone Miner Res."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"1333-8","DOI":"10.1002\/jbmr.5650110918","article-title":"The effect of weight-bearing exercise on bone mineral density: A study of female ex-elite athletes and the general population.","volume":"11","author":"J Etherington","year":"1996","journal-title":"J Bone Miner Res."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"567-73","DOI":"10.1002\/jbmr.5650080507","article-title":"Effects of weight and body mass index on bone mineral density in men and women: The Framingham study.","volume":"8","author":"D Felson","year":"1993","journal-title":"J Bone Miner Res."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"1327-42","DOI":"10.1007\/s11695-018-03685-4","article-title":"Fractures in Adults After Weight Loss from Bariatric Surgery and Weight Management Programs for Obesity: Systematic Review and Meta-analysis.","volume":"29","author":"A Ablett","year":"2019","journal-title":"Obes Surg."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"4639-50","DOI":"10.1210\/jc.2019-00074","article-title":"Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial.","volume":"104","author":"I Murai","year":"2019","journal-title":"J Clin Endocrinol Metab."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"817-20","DOI":"10.1111\/j.1742-1241.2009.02301.x","article-title":"Is obesity protective for osteoporosis?: Evaluation of bone mineral density in individuals with high body mass index.","volume":"64","author":"E Greco","year":"2010","journal-title":"Int J Clin Pract."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"857-63","DOI":"10.3349\/ymj.2010.51.6.857","article-title":"Relation between obesity and bone mineral density and vertebral fractures in Korean postmenopausal women.","volume":"51","author":"K Kim","year":"2010","journal-title":"Yonsei Med J."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"487-93","DOI":"10.1002\/jbmr.2051","article-title":"Relationship of Weight, Height, and Body Mass Index With Fracture Risk at Different Sites in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women (GLOW).","volume":"29","author":"J Compston","year":"2014","journal-title":"J Bone Miner Res."},{"key":"ref-14","first-page":"1452-63","article-title":"New insight into fat, muscle and bone relationship in women: Determining the threshold at which body fat assumes negative relationship with bone mineral density.","volume":"5","author":"P Liu","year":"2014","journal-title":"Int J Prev Med."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"540-5","DOI":"10.1016\/j.bone.2011.06.030","article-title":"New factors controlling the balance between osteoblastogenesis and adipogenesis.","volume":"50","author":"B Abdallah","year":"2012","journal-title":"Bone."},{"key":"ref-16","doi-asserted-by":"crossref","first-page":"341-51","DOI":"10.1242\/jcs.102.2.341","article-title":"Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures.","volume":"102","author":"J Beresford","year":"1992","journal-title":"J Cell Sci."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"290-4","DOI":"10.1016\/j.coph.2004.03.002","article-title":"Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications.","volume":"4","author":"M Nuttall","year":"2004","journal-title":"Curr Opin Pharmacol."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"3242-9","DOI":"10.1016\/j.febslet.2010.06.010","article-title":"PPARgamma in adipocyte differentiation and metabolism--novel insights from genome-wide studies.","volume":"584","author":"R Siersbaek","year":"2010","journal-title":"FEBS Lett."},{"key":"ref-19","first-page":"S143-51","article-title":"The effect of leptin on bone: An evolving concept of action.","volume":"57 Suppl 1","author":"V Cirmanov\u00e1","year":"2008","journal-title":"Physiol Res."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"68-75","DOI":"10.4161\/org.4.2.5851","article-title":"Wnt signal transduction pathways.","volume":"4","author":"Y Komiya","year":"2014","journal-title":"Organogenesis."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"745-56","DOI":"10.1016\/j.yexcr.2010.12.015","article-title":"Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations.","volume":"317","author":"H Taipaleenm\u00e4ki","year":"2011","journal-title":"Exp Cell Res."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"1695-705","DOI":"10.1038\/ijo.2010.107","article-title":"Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity.","volume":"34","author":"C Lagathu","year":"2010","journal-title":"Int J Obes (Lond)."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"2409-15","DOI":"10.1172\/JCI117936","article-title":"Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.","volume":"95","author":"G Hotamisligil","year":"1995","journal-title":"J Clin Invest."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"408-14","DOI":"10.1111\/j.1365-2796.2007.01852.x","article-title":"Obesity-induced inflammation: A metabolic dialogue in the language of inflammation.","volume":"262","author":"A Ferrante","year":"2007","journal-title":"J Intern Med."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3389\/fendo.2019.00269","article-title":"Mechanisms Involved in Childhood Obesity-Related Bone Fragility.","volume":"10","author":"M Faienza","year":"2019","journal-title":"Front Endocrinol (Lausanne)."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"889-94","DOI":"10.1126\/science.1141634","article-title":"A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity.","volume":"316","author":"T Frayling","year":"2007","journal-title":"Science."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"e27312","DOI":"10.1371\/journal.pone.0027312","article-title":"The fat mass and obesity associated gene, FTO, is also associated with osteoporosis phenotypes.","volume":"6","author":"Y Guo","year":"2011","journal-title":"PLoS One."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"17980-9","DOI":"10.1073\/pnas.1905489116","article-title":"The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage.","volume":"116","author":"Q Zhang","year":"2019","journal-title":"Proc Natl Acad Sci U S A."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"2050-2062.e6","DOI":"10.1016\/j.celrep.2019.04.066","article-title":"Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility.","volume":"27","author":"M Tencerova","year":"2019","journal-title":"Cell Rep."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"1052-65","DOI":"10.1002\/jbmr.3390","article-title":"Osteoblast-like MC3T3-E1 Cells Prefer Glycolysis for ATP Production but Adipocyte-like 3T3-L1 Cells Prefer Oxidative Phosphorylation.","volume":"33","author":"A Guntur","year":"2018","journal-title":"J Bone Miner Res."},{"key":"ref-31","doi-asserted-by":"publisher","first-page":"266-300","DOI":"10.1210\/er.2009-0024","article-title":"From estrogen-centric to aging and oxidative stress: A revised perspective of the pathogenesis of osteoporosis.","volume":"31","author":"S Manolagas","year":"2010","journal-title":"Endocr Rev."},{"key":"ref-32","doi-asserted-by":"publisher","first-page":"427-32","DOI":"10.1073\/pnas.1715687114","article-title":"Body weight homeostat that regulates fat mass independently of leptin in rats and mice.","volume":"115","author":"J Jansson","year":"2018","journal-title":"Proc Natl Acad Sci U S 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