{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:56:19Z","timestamp":1775858179532,"version":"3.50.1"},"reference-count":7,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Pseudoxanthoma elasticum (PXE) is a rare inherited disorder, characterised by a progressive mineralization and fragmentation of elastic fibres of the skin, retina and cardiovascular system. At an initial stage, the skin usually exhibits distinctive lesions and subsequently extra-dermal manifestations. The diagnosis is based on clinical manifestations, histological analysis of the lesions and genetic analysis.<\/ns4:p>\n                  <ns4:p>This is a case report of a 12-year-old child complaining of painless, mildly itchy yellow papules in the cervical region with 1 year of evolution.<\/ns4:p>\n                  <ns4:p>PXE is currently an incurable disease and has a favourable prognosis when cardiovascular and retinal complications are prevented and monitored.<\/ns4:p>","DOI":"10.12688\/f1000research.21431.1","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T07:35:05Z","timestamp":1578555305000},"page":"9","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Case Report: Pseudoxanthoma elasticum"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7913-2238","authenticated-orcid":false,"given":"Catarina","family":"Lucas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Aranha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"da Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6657-5921","authenticated-orcid":false,"given":"Domingos","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"89-93","DOI":"10.1111\/j.1365-2133.2006.07286.x","article-title":"Pseudoxanthoma elasticum: evaluation of diagnostic criteria based 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Neurol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"897-898","DOI":"10.1590\/abd1806-4841.20176845","article-title":"Pseudoxanthoma elasticum-like papillary dermal elastolysis.","volume":"92","author":"C Ribeiro","year":"2017","journal-title":"An Bras Dermatol."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"598262","DOI":"10.6064\/2012\/598262","article-title":"Histopathology of pseudoxanthoma elasticum and related disorders: histological hallmarks and diagnostic clues.","volume":"2012","author":"M Hosen","year":"2012","journal-title":"Scientifica (Cairo)."},{"key":"ref-7","first-page":"223-6","article-title":"Elast\u00f3lise da derme papilar semelhante a pseudoxantoma el\u00e1stico.","volume":"72","author":"L Lopes","year":"2014","journal-title":"Rev Soc Port Dermatol Venereol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/9-9\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-9\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-9\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T06:30:25Z","timestamp":1595226625000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/9-9\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,9]]},"references-count":7,"URL":"https:\/\/doi.org\/10.12688\/f1000research.21431.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.23605.r66222","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.23605.r58434","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.23605.r66211","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.23605.r66220","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.23605.r66211","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.23605.r66222","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.23605.r58434","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,9]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/9-9\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.23605.r58434, Olivier M. Vanakker, Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium, 17 Feb 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-9\/v1#referee-response-58434","order":0,"name":"referee-response-58434","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.23605.r66211, M\u00e1rta Medvecz, Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary, 17 Jul 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-9\/v1#referee-response-66211","order":1,"name":"referee-response-66211","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.23605.r66222, Annamaria Offidani, Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, Ancona, Italy, 20 Jul 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-9\/v1#referee-response-66222","order":2,"name":"referee-response-66222","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}