{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:24:51Z","timestamp":1790058291227,"version":"4.0.1"},"reference-count":55,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN2016-06066"],"award-info":[{"award-number":["RGPIN2016-06066"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-1192"],"award-info":[{"award-number":["MOP-1192"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["NIMHF32MH116592-01A1"],"award-info":[{"award-number":["NIMHF32MH116592-01A1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Even apparently simple choices, like selecting a dessert in a pastry shop, involve options characterized by multiple motivationally relevant attributes. Neuroeconomic research suggests that the human brain may track the subjective value of such options, allowing disparate reward-predictive information to be compared in a common currency. However, the brain mechanisms involved in identifying value-predictive features and combining these to assess the value of each decision option remain unclear. Here, we review recent evidence from studies of multi-attribute decision-making in people with focal frontal lobe damage and in healthy people undergoing functional magnetic resonance imaging. This work suggests that ventromedial and lateral prefrontal cortex and orbitofrontal cortex are important for forming value judgments under conditions of complexity. We discuss studies supporting the involvement of these regions in selecting among and evaluating option attributes during value judgment and decision-making and when learning from reward feedback. These findings are consistent with roles for these regions in guiding value construction. They argue for a more nuanced understanding of how ventral and lateral prefrontal cortex contribute to discovering and recognizing value, processes that are required under the complex conditions typical of many everyday decisions.<\/ns4:p>","DOI":"10.12688\/f1000research.21946.1","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T11:45:06Z","timestamp":1582890306000},"page":"158","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Under construction: ventral and lateral frontal lobe contributions to value-based decision-making and learning"],"prefix":"10.12688","volume":"9","author":[{"given":"Avinash R","family":"Vaidya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9144-092X","authenticated-orcid":false,"given":"Lesley 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.24198.r60277, Thorsten Kahnt, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, USA, 28 Feb 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-158\/v1#referee-response-60277","order":0,"name":"referee-response-60277","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.24198.r60276, Markus Ullsperger, Institute of Psychology and Center for Behavioral Brain Sciences, Otto-von-Guericke-Universit\u00e4t Magdeburg, Magdeburg, Germany, 28 Feb 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-158\/v1#referee-response-60276","order":1,"name":"referee-response-60276","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The authors acknowledge funding support from the National Institutes of Health (NIMH F32 MH116592-01A1), the Natural Sciences and Engineering Research Council of Canada (RGPIN 2016-06066), and the Canadian Institutes of Health Research (MOP-1192). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}