{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T20:12:27Z","timestamp":1773605547027,"version":"3.50.1"},"reference-count":19,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    \u00a0Core decompression is a hip preserving surgical procedure that is used to treat avascular necrosis (AVN) of the femoral head. The eventual clinical and radiological outcome following this procedure is varied in literature. Also, the time to a total hip replacement (THR) from the index procedure and the percentage of patients subsequently undergoing a THR is controversial. Furthermore, there are multiple surgical methods along with multiple augmentation techniques and various classification and staging systems described. The purpose of this systematic review, therefore, is to analyse the outcomes following decompression only, excluding any augmentation techniques for non-traumatic AVN of the femoral head.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:\u00a0<\/ns4:bold>\n                    This protocol is being developed in line with the PRISMA-P guidelines. The search strategy includes articles from Medline, Embase, Google Scholar, CINHAL and Cochrane library. The review and screening will be done by two independent reviewers. Review articles, editorials and correspondences will be excluded. Articles including patients with sickle cell disease and with core decompression where augmentation is used will be excluded. The risk of bias and quality of articles will be assessed using the Joanna Briggs Institute Critical Appraisal Checklist for the different study designs included.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Discussion:\u00a0<\/ns4:bold>\n                    This study will be a comprehensive review on all published articles having patients with AVN of the femoral head and undergoing core decompression surgery only. The systematic review will then define the outcomes of the core decompression surgery based on clinical and radiological outcomes. Each outcome will include the different stages within it and finally, the total mean time to THR will be calculated. This will then be followed by assessing the cumulative confidence in evidence from all the data collected using the GRADE tool. \u00a0\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Registration:<\/ns4:bold>\n                    \u00a0This systematic review is registered in the International Prospective Register for Systematic Reviews and Meta-analysis (PROSPERO) under the registration number:\u00a0\n                    <ns4:ext-link xmlns:ns3=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" ns3:href=\"https:\/\/protect-eu.mimecast.com\/s\/EPUwCzVBHW8qqsoU8Fy\">CRD42018100596<\/ns4:ext-link>\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.22167.1","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T08:00:06Z","timestamp":1580457606000},"page":"71","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["What are the outcomes of core decompression in patients with avascular necrosis? Protocol for a systematic review"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3743-7033","authenticated-orcid":false,"given":"Octavian","family":"Andronic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitham","family":"Shoman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ori","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9454-3978","authenticated-orcid":false,"given":"Vikas","family":"Khanduja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2020,1,31]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"pii: S0883-5403(19)31101-5","DOI":"10.1016\/j.arth.2019.11.029","article-title":"The 2019 Revised Version of 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necrosis.","volume":"85","author":"C Bergh","year":"2014","journal-title":"Acta Orthop."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"201-9","DOI":"10.1007\/s12178-015-9277-8","article-title":"Pathophysiology and risk factors for osteonecrosis.","volume":"8","author":"K Shah","year":"2015","journal-title":"Curr Rev Musculoskelet Med."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"1089-1095","DOI":"10.1007\/s00264-018-4018-4","article-title":"Classification systems of hip osteonecrosis: an updated review.","volume":"43","author":"A Sultan","year":"2019","journal-title":"Int Orthop."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"2636-9","DOI":"10.1007\/s11999-012-2416-2","article-title":"In brief: Ficat classification: avascular necrosis of the femoral head.","volume":"470","author":"M Jawad","year":"2012","journal-title":"Clin Orthop Relat 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Arbeloa-Gutierrez","year":"2016","journal-title":"Arthrosc Tech."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/scrt505","article-title":"Efficacy of autologous bone marrow buffy coat grafting combined with core decompression in patients with avascular necrosis of femoral head: a prospective, double-blinded, randomized, controlled study.","volume":"5","author":"Y Ma","year":"2014","journal-title":"Stem Cell Res Ther."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"674-80","DOI":"10.2106\/00004623-199505000-00003","article-title":"Core decompression of the osteonecrotic femoral head.","volume":"77","author":"S Smith","year":"1995","journal-title":"J Bone Joint Surg Am."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"200-9","DOI":"10.2106\/00004623-199902000-00007","article-title":"Survivorship analysis of hips treated with core decompression for nontraumatic osteonecrosis of the femoral head.","volume":"81","author":"K 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Yoon","year":"2018","journal-title":"Int Orthop."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"489-93","DOI":"10.5301\/HIP.2012.9748","article-title":"Efficacy of core decompression as treatment for osteonecrosis of the hip: a systematic review.","volume":"22","author":"M Rajagopal","year":"2012","journal-title":"Hip Int."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"132-40","DOI":"10.1097\/XEB.0000000000000055","article-title":"Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach.","volume":"13","author":"E Aromataris","year":"2015","journal-title":"Int J Evid Based Healthc."},{"key":"ref-19","article-title":"PRISMA-P checklist and flow chart for \u2018What are the Outcomes of Core Decompression in Patients with Avascular Necrosis? Protocol for a Systematic Review\u2019.","author":"O Andronic","year":"Dataset. 2020","journal-title":"figshare."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/9-71\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-71\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-71\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T11:00:09Z","timestamp":1585220409000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/9-71\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,31]]},"references-count":19,"URL":"https:\/\/doi.org\/10.12688\/f1000research.22167.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.24446.r60053","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.24446.r61725","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.24446.r61725","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.24446.r60053","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,31]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/9-71\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.24446.r60053, Tony Andrade, Department of Trauma and Orthopaedics, Royal Berkshire Hospital, Royal Berkshire NHS Foundation Trust, Reading, UK, 23 Mar 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-71\/v1#referee-response-60053","order":0,"name":"referee-response-60053","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.24446.r61725, Andreas Roth, Department of Orthopedic, Trauma and Plastic Surgery, University Clinic of Leipzig, Leipzig University, Leipzig, Germany, 26 Mar 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-71\/v1#referee-response-61725","order":1,"name":"referee-response-61725","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}