{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:12:26Z","timestamp":1790820746316,"version":"4.1.0"},"update-to":[{"DOI":"10.12688\/f1000research.22466.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000}}],"reference-count":21,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Ectopic development of teeth in nondental areas is uncommon, especially in the maxillary sinus. A panoramic radiograph is the routine diagnostic radiographic examination performed for this type of eruption, although cone beam computed tomography (CBCT) is highly recommended for further localization of the ectopic tooth and assessment of the characteristics of any associated lesion before a surgical procedure. We report a case of a 13-year-old female student who presented with purulent discharge posterior to the upper right second molar with a bad taste and foul odour. Radiographic examination revealed a maxillary third molar tooth located at the posterosuperior aspect of the right maxillary sinus with a hyperdense lesion surrounding the crown, obliterating the sinus cavity. Both the tooth and dentigerous cyst were surgically removed under general anaesthesia through Caldwell-Luc antrostomy. After a three-month follow-up, the patient was symptom free and had an uneventful recovery. The rare and critical location of the reported third molar along with the infected dentigerous cyst indicates its complete enucleation to avoid complications as recurrence or malignant transformation.<\/ns4:p>","DOI":"10.12688\/f1000research.22466.2","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T18:15:21Z","timestamp":1587147321000},"page":"209","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Case Report: Ectopic third molar in the maxillary sinus with infected dentigerous cyst assessed by cone beam CT"],"prefix":"10.12688","volume":"9","author":[{"given":"Khairy","family":"Elmorsy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8184-7443","authenticated-orcid":false,"given":"Lubna K.","family":"Elsayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1570-4524","authenticated-orcid":false,"given":"Sara M.","family":"El Khateeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"820-824","DOI":"10.1017\/s0022215100138721","article-title":"Teeth in the maxillary sinus--imaging and management.","volume":"111","author":"L Bodner","year":"1997","journal-title":"J Laryngol Otol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"667-671","DOI":"10.4103\/ijdr.IJDR_347_17","article-title":"Ectopic teeth in the maxillary sinus: A case report and literature review.","volume":"29","author":"L Lombroni","year":"2018","journal-title":"Indian J Dent Res."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"1027-1031","DOI":"10.1097\/00005537-200106000-00017","article-title":"Endoscopic extraction of an intranasal tooth: A review of 13 cases.","volume":"111","author":"F Lee","year":"2001","journal-title":"Laryngoscope."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"277-281","DOI":"10.1016\/j.anl.2006.01.004","article-title":"Clinical impact of ectopic teeth in the maxillary sinus.","volume":"33","author":"T Baykul","year":"2006","journal-title":"Auris Nasus Larynx."},{"key":"ref-5","first-page":"080-081","article-title":"Ectopic eruption of maxillary molar tooth--an unusual cause of recurrent sinusitis.","volume":"42","author":"Y Goh","year":"2001","journal-title":"Singapore Med J."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"260-263","DOI":"10.1055\/s-0036-1581063","article-title":"Unusual Case of Sinusitis Related to Ectopic Teeth in the Maxillary Sinus Roof\/Orbital Floor: A Report.","volume":"09","author":"O Chagas J\u00fanior","year":"2016","journal-title":"Craniomaxillofacial Trauma Reconstr."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"620741","DOI":"10.1155\/2014\/620741","article-title":"Ectopic 3rd Molar Tooth in the Maxillary Antrum.","volume":"2014","author":"S Bello","year":"2014","journal-title":"Case Rep Dent."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"e133-e137","DOI":"10.4317\/jced.51871","article-title":"Ectopic third molar in the mandibular sigmoid notch: Report of a case and literature review.","volume":"7","author":"Y Findik","year":"2015","journal-title":"J Clin Exp Dent."},{"key":"ref-9","doi-asserted-by":"crossref","first-page":"219-221","DOI":"10.4103\/ejo.ejo_80_18","article-title":"Ectopic third molar in maxillary sinus: an asymptomatic accidental finding.","volume":"35","author":"M Kheir","year":"2019","journal-title":"Egypt J Otolaryngol."},{"key":"ref-10","first-page":"E6-E11","article-title":"Ectopic molar in the maxillary sinus precipitating a mucocele: a case report and literature review.","volume":"88","author":"J Lamb","year":"2009","journal-title":"Ear Nose Throat J."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"344-349","DOI":"10.1093\/ejo\/cjq102","article-title":"Two- versus three-dimensional imaging in subjects with unerupted maxillary canines.","volume":"33","author":"S Botticelli","year":"2011","journal-title":"Eur J Orthod."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"225-234","DOI":"10.1016\/j.tripleo.2005.10.039","article-title":"Assessment of bone segmentation quality of cone-beam CT versus multislice spiral CT: a pilot study.","volume":"102","author":"M Loubele","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"ref-13","first-page":"75-80","article-title":"Clinical Applications of Cone-Beam Computed Tomography in Dental Practice.","volume":"72","author":"W Scarfe","year":"2006","journal-title":"J Can Dent Assoc."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"93-102","DOI":"10.1093\/ejo\/cjq034","article-title":"Comparison of two cone beam computed tomographic systems versus panoramic imaging for localization of impacted maxillary canines and detection of root resorption.","volume":"33","author":"A Alqerban","year":"2011","journal-title":"Eur J Orthod."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"13-18","DOI":"10.1179\/1465313313Y.0000000076","article-title":"Localization of ectopic maxillary canines -- is CBCT more accurate than conventional horizontal or vertical parallax?","volume":"41","author":"P Serrant","year":"2014","journal-title":"J Orthod."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"67-71","DOI":"10.1016\/j.tripleo.2009.07.043","article-title":"Dentigerous cyst associated with an ectopic tooth in the maxillary sinus: a report of 3 cases and review of the literature.","volume":"109","author":"M Buyukkurt","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"72-78","DOI":"10.1111\/ors.12111","article-title":"Maxillary dentigerous cyst associated with an ectopic third molar in the maxillary sinus: a literature review and report of six consecutive cases.","volume":"7","author":"S Sivolella","year":"2014","journal-title":"Oral Surg."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1177\/014556130808700606","article-title":"Endoscopic view of a maxillary dentigerous cyst.","volume":"87","author":"D Christmas","year":"2008","journal-title":"Ear Nose Throat J."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"e568-e570","DOI":"10.1097\/SCS.0000000000004346","article-title":"Endoscopically Assisted Modified Caldwell-Luc Approach to Enucleation of Dentigerous Cyst With Ectopic Tooth From the Maxillary Sinus.","volume":"29","author":"I Liau","year":"2018","journal-title":"J Craniofac Surg."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"756-758","DOI":"10.4103\/0970-9290.127628","article-title":"Transoral removal of ectopic maxillary third molar situated superiorly to maxillary antrum and posteroinferiorly to the floor of orbit.","volume":"24","author":"A Rai","year":"2013","journal-title":"Indian J Dent Res."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"48-51","DOI":"10.4103\/2321-4848.113566","article-title":"Ectopic premolar tooth in the maxillary sinus: A case report and review of literature.","volume":"1","author":"K Gangadhara Somayaji","year":"2013","journal-title":"Arch Med Health Sci."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/9-209\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-209\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-209\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:18:02Z","timestamp":1696040282000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/9-209\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,16]]},"references-count":21,"URL":"https:\/\/doi.org\/10.12688\/f1000research.22466.2","relation":{},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,16]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/9-209\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.24794.r61698, Najla Dar-odeh, Department of Oral Basic and Clinical Sciences, College of Dentistry, Taibah University, Al Madinah Al Munawarah, Saudi Arabia, 02 Apr 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-209\/v1#referee-response-61698","order":0,"name":"referee-response-61698","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>sara elkhateeb<\/b>; <i>Posted: 04 Apr 2020<\/i>; <b>Comment No 1<\/b>The term \u201cectopic eruption\u201d was used throughout the text, however, taking into consideration the age&nbsp;of the patient and the definition of \u201ceruption\u201d, it is preferable to replace it with the term \u201cectopic tooth\u201d. <b>Reply to No 1:<\/b>The term \u201ceruption\u201d means <b>emission<\/b>, <b>ejection<\/b> or <b>discharge<\/b>. Since the molar was clinically \u201cvisible\u201d in&nbsp;the maxillary sinus, it is scientifically correct to describe it as \u201ceruption\u201d inside maxillary sinus.Also, the term \u201cectopic eruption\u201d was previously reported in papers published in indexed journals in similar ectopic cases in maxillary sinus. <b>Paper examples:<\/b>-Sharma S, Chauhan JS. Bilateral ectopic third molars in maxillary sinus associated with dentigerous cyst.\u2014A rare case report. International journal of surgery case reports. 2019 Jan 1; 61:298-301.-Lombroni LG, Farronato G, Santamaria G, Lombroni DM, Gatti P, Capelli M. Ectopic teeth in the maxillarysinus: A case report and literature review. Indian Journal of Dental Research. 2018 Sep 1;29(5):667.-Jalal H, Hicham S, Lahcen K, Karim EK. Dentigerous Cyst Associated with an Ectopic Third Molar in the Maxillary Sinus: Report of Cases and Review of Literature. Oral &amp; Maxillofacial Pathology Journal. 2018 Jan 1;9(1). <b>&nbsp;Comment No 2<\/b>Literature review was thorough, however, several references were published more than a decade ago. <b>Reply to No 2:&nbsp;<\/b>We agree to some extent with this comment, reference no. 2 will be replaced with:Lombroni L, Farronato G, Santamaria G, Lombroni D, Gatti P, Capelli M. Ectopic teeth in the maxillary sinus: A case report and literature review. <i>Indian J Dent Res<\/i>. 2018;29(5):667.For the rest of references, we cannot make any changes in them as we think that having diversity in time ranges in the references and enriches our literature, as we included also 2013\/14\/18 and 19 articles. <b>Comment No 3<\/b>Discussion: first paragraph mentions that exact aetiology is not clear, what do you think the aetiology for&nbsp;ectopic tooth is in your case? <b>Reply to No 3<\/b>There is no exact etiology for ectopic teeth development, there are multiple theories to get closer to the exact cause. We will add the following statement to get closer to the etiology of developing ectopic molar in our case:&quot;In our case, we may suggest that the theory of the associated pathology with the third molar might have caused its ectopic location&quot;.(To be added at the end of the first paragraph in discussion).&nbsp; <b>Comment No 4<\/b>Discussion: How many cases of ectopic teeth in the maxillary sinus were reported so far? And how many&nbsp;of them were for third molars? <b>Reply to No 4<\/b>According to latest review of literature 2018 (added ref no 2) there were 51 patients were observed, with higher prevalence of ectopic teeth in the third molars, 21 cases.&nbsp;Lombroni L, Farronato G, Santamaria G, Lombroni D, Gatti P, Capelli M. Ectopic teeth in the maxillary sinus: A case report and literature review. <i>Indian J Dent Res<\/i>. 2018;29(5):667. <b> <\/b>","URL":"https:\/\/f1000research.com\/articles\/9-209\/v2#referee-comment-5395","order":1,"name":"referee-comment-5395","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.24794.r61700, Shadia Abdel-Hameed Elsayed, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt, 03 Apr 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-209\/v1#referee-response-61700","order":2,"name":"referee-response-61700","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>sara elkhateeb<\/b>; <i>Posted: 04 Apr 2020<\/i>; <b>Comment No 1&nbsp;<\/b>Title need to be summarized and &quot;assessed by cone beam CT&quot; could be removed from the title. <b>Reply to No 1<\/b>We prefer to keep the title as it is, we think its more enriching to the title to elaborate on the radiographic assessment of the case, especially that we noticed some ectopic cases were not evaluated using CBCT. <b>Comment No 2 <\/b>Case reports are usually describing a very rare condition however dentigerous cyst in the maxillary sinus is not uncommon. <b>Reply to No 2<\/b>Our report is focusing on the ectopic location of the molar \u201cwhich is a rare condition\u201d and being associated with dentigerous cyst. <b>Comment No 3<\/b>Figure 3 is an intraoperative photo not perioperative image. <b>Reply to No 3<\/b>The prefix \u201cPeri\u201d means \u201cIntra or during\u201d, so no change will be performed.&nbsp;FYI prefix \u201cPre\u201d means \u201cbefore\u201d <b>Comment No 4<\/b>Usually dentigerous cyst is diagnosed mainly by association with impacted tooth so the conclusion of the paper needs to be more accurate as this case is not ectopic eruption.The following paragraph is more accurately describing the present case: In the present paper, we report a case of infected dentigerous cyst associated with an ectopic molar within the maxillary sinus. Surgical removal for both was performed, and the entire pathologic antral tissue was removed completely and assessed histologically. There were no post-surgical complications, and the patient\u2019s postoperative healing was satisfactory. <b>Reply to No 4<\/b>a) The term \u201ceruption\u201d means <b>emission<\/b>, <b>ejection<\/b> or <b>discharge<\/b>. Since the molar was clinically \u201cvisible\u201d in the maxillary sinus, it is scientifically correct to describe it as \u201ceruption\u201d inside maxillary sinus.&nbsp;Also, the term \u201cectopic eruption\u201d was previously reported in papers published in indexed journals in same ectopic cases in maxillary sinus. <b>Paper examples:<\/b> Sharma S, Chauhan JS. Bilateral ectopic third molars in maxillary sinus associated with dentigerous cyst: A rare case report. International journal of surgery case reports. 2019 Jan 1; 61:298-301. Lombroni LG, Farronato G, Santamaria G, Lombroni DM, Gatti P, Capelli M. Ectopic teeth in the maxillary sinus: A case report and literature review. Indian Journal of Dental Research. 2018 Sep 1;29(5):667. Jalal H, Hicham S, Lahcen K, Karim EK. Dentigerous Cyst Associated with an Ectopic Third Molar in the Maxillary Sinus: Report of Cases and Review of Literature. Oral &amp; Maxillofacial Pathology Journal. 2018 Jan 1;9(1). b) Conclusion preferably to contain a recommendation, your kind suggestion of the paragraph is already included in the paper, so we prefer to keep both. <b>Comment No 5&nbsp;<\/b>&nbsp;Ectopic eruption definition needs more justification as the present tooth is ectopic but associated with large maxillary cyst and pushed superiorly as result of cyst enlargement <b>Reply to No 5<\/b>We already put general statement in the introduction about the definition of ectopic eruption and the&nbsp;different theories of the causes of its occurrence were discussed in the discussion part. In our case the third molar is in ectopic location and erupted inside the maxillary sinus where the associated pericoronal cyst was the suggested theory for its location. <b>Comment No 6&nbsp;<\/b>Authors did not report any prevalence rate of the dentigerous cyst (which usually associated with impacted wisdom) in the maxillary sinus and also the rate for ectopic impacted teeth in the sinus. <b>Reply to No 6<\/b>As it is a case report without review of literature, we didn\u2019t go through prevalence of reported conditions, but we agree it is advantageous to be included. <b>Comment No 7&nbsp;<\/b>The cystic lesion had discharge and was diagnosed as infected cyst, does the surgeon treat infection before opening the sinus. <b>Reply to No 7<\/b>It was a chronic condition due to long standing infection, managing the case in this case will be symptomatic only, so we thought that best managing will be through surgical eradication of the source.&nbsp; <b>Possibility of recurrent fistula is high?<\/b>Patient had a 12 months post-surgery follow-up and no fistula was developed.Why is nasal anticongestant not prescribed as routine post sinus surgery? <b>Reply<\/b>It was prescribed.","URL":"https:\/\/f1000research.com\/articles\/9-209\/v2#referee-comment-5396","order":3,"name":"referee-comment-5396","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This research was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding Program.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}