{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:27:49Z","timestamp":1787934469182,"version":"build-2784847793"},"reference-count":18,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["175037"],"award-info":[{"award-number":["175037"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Health, Exercise and Sport Sciences"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    The traditional treatment of soft tissue injuries consists of the RICE protocol \u2013 rest, ice, compression, and elevation, followed for up to 72 hours after a trauma. Although designed as an immediate therapy to reduce inflammation that occurs after an acute injury, the RICE protcol might not be the best way to promote healing due to limiting blood flow. Molecular hydrogen (H\n                    <ns4:sub>2<\/ns4:sub>\n                    ) has recently been put forward as a possible adjuvant treatment in musculoskeletal medicine, yet limited data are available concerning its effectiveness as a first-aid intervention.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Case report:<\/ns4:bold>\n                    We report here a case of an elite professional athlete who suffered a grade II ankle sprain, and who subsequently received six sessions of ankle and foot hydrotherapy (e.g. 30-min at every four hours) with super-saturated hydrogen-rich water during the first 24 hours post-injury. The pain VAS self\u2010completed by the patient dropped from 50 points (moderate pain) at baseline (immediately after injury) to 20 points (mild pain) at 24-h follow-up. Ankle swelling dropped by 2.8% and dorsiflexion range of movement improved by 27.9% from baseline to follow-up, respectively.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    Our case has indicated that an acute multi-session hydrotherapy with hydrogen-rich water might be a helpful treatment in terms of pain, swelling reduction and regaining range of motion after an ankle sprain.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.22850.1","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T05:40:06Z","timestamp":1586324406000},"page":"245","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete"],"prefix":"10.12688","volume":"9","author":[{"given":"Dejan","family":"Javorac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdemar","family":"Stajer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-2541","authenticated-orcid":false,"given":"Sergej","family":"Ostojic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"1497-1503","DOI":"10.1136\/bjsports-2015-095180","article-title":"Biological variation in musculoskeletal injuries: current knowledge, future research and practical implications.","volume":"49","author":"M Collins","year":"2015","journal-title":"Br J Sports Med."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"160-166","DOI":"10.21037\/tp.2017.04.08","article-title":"Epidemiology of sports-related musculoskeletal injuries in young athletes in United States.","volume":"6","author":"D Patel","year":"2017","journal-title":"Transl Pediatr."},{"key":"ref-3","first-page":"93-104","article-title":"Management of ankle sprains.","volume":"63","author":"M Wolfe","year":"2001","journal-title":"Am Fam Physician."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"435-443","DOI":"10.4085\/1062-6050-47.4.14","article-title":"What is the evidence for rest, ice, compression, and elevation therapy in the treatment of ankle sprains in adults?","volume":"47","author":"M van den Bekerom","year":"2012","journal-title":"J Athl Train."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"251-261","DOI":"10.1177\/0363546503260757","article-title":"The use of ice in the treatment of acute soft-tissue injury: a systematic review of randomized controlled trials.","volume":"32","author":"C Bleakley","year":"2004","journal-title":"Am J Sports Med."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.12688\/f1000research.9758.1","article-title":"Should hydrogen therapy be included in a musculoskeletal medicine routine? [version 1; peer review: 2 approved].","volume":"5","author":"S Ostojic","year":"2016","journal-title":"F1000Res."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"187-195","DOI":"10.3810\/pgm.2014.09.2813","article-title":"Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries.","volume":"126","author":"S Ostojic","year":"2014","journal-title":"Postgrad Med."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"195-201","DOI":"10.2114\/jpa2.30.195","article-title":"Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy in gastrocnemius muscle.","volume":"30","author":"R Fujita","year":"2011","journal-title":"J Physiol Anthropol."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"26-34","DOI":"10.1080\/13510002.2015.1135580","article-title":"Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice.","volume":"22","author":"S Hasegawa","year":"2017","journal-title":"Redox Rep."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"969-978","DOI":"10.1007\/s00198-012-2028-4","article-title":"Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats.","volume":"24","author":"Y Sun","year":"2013","journal-title":"Osteoporos Int."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"1412-1420","DOI":"10.1111\/bph.12036","article-title":"Hydrogen water consumption prevents osteopenia in ovariectomized rat.","volume":"168","author":"J Guo","year":"2013","journal-title":"Br J Pharmacol."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/2045-9912-2-27","article-title":"Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study.","volume":"2","author":"T Ishibashi","year":"2012","journal-title":"Med Gas 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perspectives.","volume":"36","author":"S Ostojic","year":"2015","journal-title":"Int J Sports Med."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"971-982","DOI":"10.3109\/10715762.2010.500328","article-title":"Recent advances in hydrogen research as a therapeutic medical gas.","volume":"44","author":"C Huang","year":"2010","journal-title":"Free Radic Res."},{"key":"ref-18","article-title":"Concentration and solubility of H2."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/9-245\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-245\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-245\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T05:45:50Z","timestamp":1588225550000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/9-245\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,8]]},"references-count":18,"URL":"https:\/\/doi.org\/10.12688\/f1000research.22850.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.25228.r62120","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.25228.r62119","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.25228.r62120","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.25228.r62119","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,8]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/9-245\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.25228.r62119, Steven R. Brenner, Department of Neurology and Psychiatry, Saint Louis University School of Medicine, St. Louis, MO, USA, 21 Apr 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-245\/v1#referee-response-62119","order":0,"name":"referee-response-62119","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Sergej Ostojic<\/b>; \n<i>Posted: 30 Apr 2020<\/i>; Thank you for your comment.  We haven't been able to evaluate post-injury recovery in terms of return to athletic competition due to the nature of this study, However, this issue requires an additional trial since this aspect might be of great importance for professional athletes who usually strive for re-getting to competition as soon as possible.","URL":"https:\/\/f1000research.com\/articles\/9-245\/v1#referee-comment-5471","order":1,"name":"referee-comment-5471","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.25228.r62120, Cheong Hwa Ooi, Lifestyle Science Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Malaysia, 30 Apr 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-245\/v1#referee-response-62120","order":2,"name":"referee-response-62120","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Sergej Ostojic<\/b>; \n<i>Posted: 30 Apr 2020<\/i>; Thank you for your valuable comments and notes.  We confirmed that the right ankle was injured yet we depicted here a mirror image.  Also, the intensive hydrogen treatment might disrupt sleeping time but that's the case with all intensive measures for acute ankle injuries since the treatment requires immediate and intensive care during the firts 24 to 48 h do to specific pathophysiology.  Further studies are highly warranted to evaluate the possible effects of hydrogen on blood flow, a factor that might contribute to its mechanism(s) of action.","URL":"https:\/\/f1000research.com\/articles\/9-245\/v1#referee-comment-5470","order":3,"name":"referee-comment-5470","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study is supported by the Serbian Ministry of Education, Science and Technological Development [175037] and the Center for Health, Exercise and Sport Sciences, Belgrade. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}