{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:08:38Z","timestamp":1790201318023,"version":"4.1.0"},"update-to":[{"DOI":"10.12688\/f1000research.23277.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000}},{"DOI":"10.12688\/f1000research.23277.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000}}],"reference-count":19,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Echinococcosis, also known as hydatid disease, is a common parasitic human infestation found in sheep-breeding areas. It is caused by the larvae stage of <ns4:italic>Echinococcus granulosus<\/ns4:italic>, and cysts develop mostly in the lungs and the liver. Cardiac involvement is unusual and silent until acute complications or a fatal outcome occurs. Herein, we report an autopsy case of a young healthy adult who died suddenly. The autopsy revealed an external bulging on the right heart ventricle outlet with a fluid-filled cystic cavity discovered on sectioning. Dissection of other organs did not reveal other cyst locations. Histological examination ascertained the diagnosis of hydatid cyst, and death was attributed to cardiac arrhythmias. Pathologists should keep in mind that hydatid cysts can develop anywhere in the body. Solitary cardiac cyst is rare and can simulate a \u201csilent bomb\u201d. Unfortunately, sudden death remains the frequent manner of revelation of this disease in endemic areas.<\/ns4:p>","DOI":"10.12688\/f1000research.23277.3","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T14:45:47Z","timestamp":1663857947000},"page":"286","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Sudden death related to unrecognized cardiac hydatid cyst"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-7572","authenticated-orcid":false,"given":"Med Amin","family":"Mesrati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosra","family":"Mahjoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouha","family":"Ben Abdejlil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-3234","authenticated-orcid":false,"given":"Marwa","family":"Boussaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Belhaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4354-1814","authenticated-orcid":false,"given":"Hiba","family":"Limem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Chadly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelfeteh","family":"Zakhama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abir","family":"Aissaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"262-4","DOI":"10.1097\/01.paf.0000136443.46066.dc","article-title":"Cardiac hydatid cyst rupture as cause of death.","volume":"25","author":"A Chadly","year":"2004","journal-title":"Am J Forensic Med Pathol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"400-2","DOI":"10.1111\/j.1556-4029.2006.00056.x","article-title":"Sudden death due to an unrecognized cardiac hydatid cyst: three medicolegal autopsy cases.","volume":"51","author":"I Pakis","year":"2006","journal-title":"J Forensic Sci."},{"key":"ref-3","first-page":"385-433","article-title":"Infectious diseases: fungal, protozoal and helminthic diseases and sarcoidosis","author":"R Cotran","year":"1989"},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"304-308","DOI":"10.5830\/CVJA-2017-006","article-title":"New World's old disease: cardiac hydatid disease and surgical principles.","volume":"28","author":"O Tanyeli","year":"2017","journal-title":"Cardiovasc J Afr."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"1011-27","DOI":"10.4269\/ajtmh.12-0692","article-title":"A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations.","volume":"88","author":"C Budke","year":"2013","journal-title":"Am J Trop Med Hyg."},{"key":"ref-6","first-page":"197-219","article-title":"Mycotic, protozoan and helminthic infections","author":"W Anderson","year":"1980"},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"1062-4","DOI":"10.1520\/JFS15520J","article-title":"Sudden death due to an unrecognized cardiac hydatid cyst.","volume":"47","author":"V Malamou-Mitsi","year":"2002","journal-title":"J Forensic Sci."},{"key":"ref-8","first-page":"29","article-title":"Hydatiden in demherzeneineskindes.","volume":"9","author":"W Williams","year":"1836","journal-title":"Schmidts Jahrb."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"366-74","DOI":"10.1161\/01.cir.27.3.366","article-title":"Intracardiac rupture of hydatid cysts of the heart. A study based on three personal observations and 101 cases in the world literature.","volume":"27","author":"R Di bello","year":"1963","journal-title":"Circulation."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"892-901","DOI":"10.1016\/S0022-5223(19)34268-0","article-title":"Surgical treatment of hydatid cysts of the heart: report of six cases.","volume":"98","author":"M Ameli","year":"1989","journal-title":"J Thorac Cardiovasc Surg."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"155-6","DOI":"10.1136\/adc.66.1.155","article-title":"Cardiac Echinococcosis With Fatal Intracerebral Embolism.","volume":"66","author":"R Byard","year":"1991","journal-title":"Arch Dis Child."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"1083-5","DOI":"10.1016\/0002-8703(92)90999-c","article-title":"Dynamic Left Ventricular Outflow Obstruction Caused by Cardiac Echinococcosis.","volume":"124","author":"A Lanzoni","year":"1992","journal-title":"Am Heart J."},{"key":"ref-13","first-page":"199-201","article-title":"Thromboembolism: A Rare Complication of Cardiac Hydatidosis.","volume":"54","author":"V Trehan","year":"2002","journal-title":"Indian Heart J."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"1290-4","DOI":"10.1016\/s0003-4975(99)00692-x","article-title":"A clinical dilemma: cardiac and pericardiac echinococcosis.","volume":"68","author":"C Birincio\u011flu","year":"1999","journal-title":"Ann Thorac Surg."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"226-32","DOI":"10.2214\/AJR.07.2035","article-title":"Cardiac hydatid disease: CT and MRI findings.","volume":"190","author":"M Dursun","year":"2008","journal-title":"AJR Am J Roentgenol."},{"key":"ref-16","first-page":"667-669","article-title":"Kyste hydatique du coeur droit et hypertension pulmonaire post-embolique.","volume":"5","author":"Y Pansard","year":"1987","journal-title":"Arch Mal Coeur Vaiss."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"125-8","DOI":"10.1007\/bf00200469","article-title":"Sudden death caused by hydatid embolism.","volume":"98","author":"L Buris","year":"1987","journal-title":"Z Rechtsmed."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"489-491","DOI":"10.1177\/0218492318817665","article-title":"Right ventricular hydatid cyst presented as tachyarrhythmia.","volume":"27","author":"S Singh","year":"2019","journal-title":"Asian Cardiovasc Thorac Ann."},{"key":"ref-19","article-title":"Mort subite et kyste hydatique.","author":"A Aissaoui","year":"2011"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/9-286\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-286\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-286\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T14:46:04Z","timestamp":1663857964000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/9-286\/v3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,22]]},"references-count":19,"URL":"https:\/\/doi.org\/10.12688\/f1000research.23277.3","relation":{},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,22]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/9-286\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.25698.r63961, Mejdi Ben Messaoud, Cardiology A Department, Fattouma Bourguiba University Hospital, Monastir, Tunisia, 02 Jun 2020, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/9-286\/v1#referee-response-63961","order":0,"name":"referee-response-63961","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>med amin mesrati<\/b>; \n<i>Posted: 02 Jun 2020<\/i>; Dear Reviewer,Thank you for your considerations.Response to question 1: the autopsy findings and histological tests which are always more accurate than pre-mortem imaging had excluded a pulmonary embolism or obstruction of the RV. Thus we attributed the death to cardiac arrythmiasResponse to question 2: we report in the section of the case report that others organs were unremarkable. This is to say that kidney and brain didn't exhibit hydatid cyst.Cordially","URL":"https:\/\/f1000research.com\/articles\/9-286\/v3#referee-comment-5571","order":1,"name":"referee-comment-5571","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.31143.r76284, Omer Tanyeli, Department of Cardiovascular Surgery, Meram Medicine Faculty, Necmettin Erbakan University, Konya, Turkey, 18 Jan 2021, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/9-286\/v2#referee-response-76284","order":2,"name":"referee-response-76284","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}