{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:09:15Z","timestamp":1793909355610,"version":"4.8.0"},"update-to":[{"DOI":"10.12688\/f1000research.24114.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000}},{"DOI":"10.12688\/f1000research.24114.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000}},{"DOI":"10.12688\/f1000research.24114.3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000}},{"DOI":"10.12688\/f1000research.24114.4","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000}},{"DOI":"10.12688\/f1000research.24114.5","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000}},{"DOI":"10.12688\/f1000research.24114.6","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000}},{"DOI":"10.12688\/f1000research.24114.7","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000}}],"reference-count":45,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Pesticide exposure might increase risk of lung cancer. The purpose of this study was to investigate the association between the historical use of pesticides and lung cancer using a case-control design. Methods This case-control study compared a lifetime pesticide exposure of 233 lung cancer cases, and 447 healthy neighbours matched for gender, and age (\u00b15 years). Data on demographic, pesticide exposure and other related factors were collected using a face-to-face interview questionnaire. Associations between lung cancer and types of pesticides as well as individual pesticides were analysed using logistic regression adjusted for gender, age, cigarette smoking, occupation, cooking fumes exposure, and exposure to air pollution. Results It was found that lung cancer was positively associated with the lifetime use of herbicides and insecticides. Compared to people in the non-exposed groups, those in Q3-Q4 days of using herbicides and insecticides had an elevated risk of lung cancer, with odds ratio (OR) between 2.20 (95% confidence interval (CI) 1.24-3.89), and 3.99 (95% CI 1.62-7.11) (p &lt; 0.001). For individual pesticides, those presenting a significant association with lung cancer were dieldrin (OR = 2.56; 95% CI 1.36-4.81), chlorpyrifos (OR = 3.29; 95 % CI 1.93-5.61), and carbofuran (OR = 2.10; 95% CI 1.28-3.42). It was also found, for the first time, carbofuran, glyphosate, and paraquat to be significantly associated with lung cancer. Conclusions The study confirmed dieldrin, and chlorpyrifos as risk factors and suggested carbofuran, glyphosate, and paraquat as potential risk factors for the disease. The paper stands as a noteworthy contribution to literature, particularly because the majority of publications on the topic originate from developed Western countries. However, further studies are imperative to validate the results and pinpoint additional individual pesticides that may be associated with lung cancer.<\/ns3:p>","DOI":"10.12688\/f1000research.24114.8","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T12:40:17Z","timestamp":1704372017000},"page":"492","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Pesticide exposure and lung cancer risk: A case-control study in Nakhon Sawan, Thailand"],"prefix":"10.12688","volume":"9","author":[{"given":"Teera","family":"Kangkhetkron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0321-5325","authenticated-orcid":false,"given":"Chudchawal","family":"Juntarawijit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"394-424","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","volume":"68","author":"F Bray","year":"2018","journal-title":"CA Cancer J Clin."},{"key":"ref-2","article-title":"Thailand cancer statistics 2018: GLOBOCAN","year":"2019"},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"256-263","DOI":"10.1093\/ije\/26.2.256","article-title":"Family history of cancer and risk of lung cancer in lifetime non-smokers and long-term ex-smokers.","volume":"26","author":"R Brownson","year":"1997","journal-title":"Int J Epidemiol."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"1-16","DOI":"10.1016\/0169-5002(93)90649-I","article-title":"Lung cancer: Worldwide variation in occurrence and proportion attributable to tobacco use.","volume":"9","author":"D Parkin","year":"1993","journal-title":"Lung Cancer J."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"129-138","DOI":"10.1016\/s0361-090x(02)00038-7","article-title":"Risk factors for lung cancer among Canadian women who have never smoked.","volume":"26","author":"J Hu","year":"2002","journal-title":"Cancer Detect Prev."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"134-139","DOI":"10.5491\/SHAW.2010.1.2.134","article-title":"Occupational Lung Cancer Surveillance in South Korea, 2006-2009.","volume":"1","author":"J Leem","year":"2010","journal-title":"Saf Health Work."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"1-11","DOI":"10.1006\/enrs.1993.1001","article-title":"Risk Factors for Lung Cancer Among Nonsmoking Illinois Residents.","volume":"60","author":"J Keller","year":"1993","journal-title":"Environ Res."},{"key":"ref-8","doi-asserted-by":"crossref","first-page":"488-494","DOI":"10.1097\/00001648-199909000-00005","article-title":"Lung cancer and indoor air pollution arising from Chinese-style cooking among Nonsmoking women living in Shanghai, China.","volume":"10","author":"L Zhong","year":"1999","journal-title":"Epidemiology."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"238-263","DOI":"10.1080\/10937404.2012.632358","article-title":"Occupational pesticide exposures and cancer risk: a review.","volume":"15","author":"M Alavanja","year":"2012","journal-title":"J Toxicol Environ Health B Crit Rev."},{"key":"ref-10","first-page":"1244-1247","article-title":"[Arsenic cancer in vintagers].","volume":"42","author":"G Jungmann","year":"1966","journal-title":"Landarzt."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"310-318","DOI":"10.1007\/BF01804981","article-title":"Cohort mortality and nested case-control study of lung cancer among structural pest control workers in Florida (United States).","volume":"5","author":"A Pesatori","year":"1994","journal-title":"Cancer Causes Control."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"1167-1175","DOI":"10.1002\/ijc.29416","article-title":"Use of acetochlor and cancer incidence in the Agricultural Health Study.","volume":"137","author":"C Lerro","year":"2015","journal-title":"Int J Cancer."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"3035-3039","DOI":"10.7314\/apjcp.2014.15.7.3035","article-title":"Risk Factors for Lung Cancer in the Pakistani Population.","volume":"15","author":"M Luqman","year":"2014","journal-title":"Asian Pac J Cancer Prev."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"876-885","DOI":"10.1093\/aje\/kwh290","article-title":"Pesticides and lung cancer risk in the Agricultural Health Study cohort.","volume":"160","author":"M Alavanja","year":"2004","journal-title":"Am J Epidemiol."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"642-649","DOI":"10.1002\/ijc.22258","article-title":"Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study.","volume":"120","author":"M Purdue","year":"2007","journal-title":"Int J Cancer."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"496-503","DOI":"10.1136\/oemed-2014-102728","article-title":"Incidence of solid tumours among pesticide applicators exposed to the organophosphate insecticide diazinon in the Agricultural Health Study: an updated analysis.","volume":"72","author":"R Jones","year":"2015","journal-title":"Occup Environ Med."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"1781-1789","DOI":"10.1093\/jnci\/djh324","article-title":"Cancer incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study.","volume":"96","author":"W Lee","year":"2004","journal-title":"J Natl Cancer Inst."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"663-670","DOI":"10.1007\/s10552-012-9921-1","article-title":"Poultry and livestock exposure and cancer risk among farmers in the Agricultural Health Study.","volume":"23","author":"L Beane Freeman","year":"2012","journal-title":"Cancer Causes Control."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"302-307","DOI":"10.1097\/01.ede.0000201398.82658.50","article-title":"Pendimethalin Exposure and Cancer Incidence Among Pesticide Applicators.","volume":"17","author":"L Hou","year":"2006","journal-title":"Epidemiology."},{"key":"ref-20","article-title":"The report of cancer incidence cases in Thailand, Thai Cancer Based Online (TCB)","year":"2018"},{"key":"ref-21","first-page":"444","article-title":"Methods in Observational Epidemiology","author":"J Kelsey","year":"1996"},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"420-425","DOI":"10.1097\/JTO.0000000000000433","article-title":"Perception of lung cancer among the general population and comparison with other cancers.","volume":"10","author":"J Mazi\u00e8res","year":"2015","journal-title":"J Thorac Oncol."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"121-132","DOI":"10.1016\/j.ijheh.2006.08.006","article-title":"Pesticide poisoning of farm workers-implications of blood test results from Vietnam.","volume":"210","author":"S Dasgupta","year":"2007","journal-title":"Int J Hyg Environ Health."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"1019-1028","DOI":"10.1093\/oxfordjournals.aje.a116396","article-title":"Selection of controls in case-control studies. I. Principles.","volume":"135","author":"S Wacholder","year":"1992","journal-title":"Am J Epidemiol."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12199-018-0692-5","article-title":"Association between diabetes and pesticides: a case-control study among Thai farmers.","volume":"23","author":"C Juntarawijit","year":"2018","journal-title":"Environ Health Prev Med."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"412-416","DOI":"10.1016\/j.envint.2005.10.001","article-title":"Pesticide exposure and lung cancer mortality in Leningrad province in Russia.","volume":"32","author":"W Lee","year":"2006","journal-title":"Environ Int."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"157-165","DOI":"10.1016\/j.toxlet.2013.11.009","article-title":"Environmental exposure to pesticides and cancer risk in multiple human organ systems.","volume":"230","author":"T Parr\u00f3n","year":"2014","journal-title":"Toxicol Lett."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"120-142","DOI":"10.3322\/caac.21170","article-title":"Increased Cancer Burden Among Pesticide Applicators and Others Due to Pesticide Exposure.","volume":"63","author":"M Alavanja","year":"2013","journal-title":"CA Cancer J Clin."},{"key":"ref-31","article-title":"A review of the role pesticides play in some cancer: children, farmers and pesticide users at risk.","author":"G Lyons","year":"2010","journal-title":"CHEM Trust Report."},{"key":"ref-32","doi-asserted-by":"publisher","first-page":"1-12","DOI":"10.1006\/taap.2001.9347","article-title":"Effects of Currently Used Pesticides in Assays for Estrogenicity, Androgenicity, and Aromatase Activity in Vitro.","volume":"179","author":"H Andersen","year":"2002","journal-title":"Toxicol Appl Pharmacol."},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"544-551","DOI":"10.1289\/EHP456","article-title":"Occupational Exposure to Pesticides and the Incidence of Lung Cancer in the Agricultural Health Study.","volume":"125","author":"M Bonner","year":"2017","journal-title":"Environ Health Perspect."},{"key":"ref-34","doi-asserted-by":"publisher","DOI":"10.18103\/mra.v0i3.176","article-title":"Pesticides used in Thailand and toxic effects to human health.","author":"A Tawatsin","year":"2015","journal-title":"Med Res Archives."},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"285-289","DOI":"10.1289\/ehp.7451","article-title":"Occupational exposure to carbofuran and the incidence of cancer in the Agricultural Health Study.","volume":"113","author":"M Bonner","year":"2005","journal-title":"Environ Health Perspect."},{"key":"ref-36","first-page":"1155-63","article-title":"Non-Hodgkin\u2019s Lymphoma and Specific Pesticide Exposures in Men: Cross-Canada Study of Pesticides and Health.","volume":"10","author":"H McDuffie","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"ref-37","doi-asserted-by":"publisher","first-page":"102-120","DOI":"10.1177\/1048291115569028","article-title":"Occupational Health and Safety for Agricultural workers in Thailand: Gaps and Recommendations, with a Focus on Pesticide Use.","volume":"25","author":"O Kaewboonchoo","year":"2015","journal-title":"New Solut."},{"key":"ref-38","doi-asserted-by":"publisher","first-page":"509-516","DOI":"10.1093\/jnci\/djx233","article-title":"Glyphosate Use and Cancer Incidence in The Agricultural Health Study.","volume":"110","author":"G Andreotti","year":"2018","journal-title":"J Natl Cancer Inst."},{"key":"ref-39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58599-y","article-title":"Toxicology of paraquat and pharmacology of the protective effect of 5-hydroxy-1-methylhydantoin on lung injury caused by paraquat based on metabolomics.","volume":"10","author":"L Gao","year":"2020","journal-title":"Sci Rep."},{"key":"ref-40","doi-asserted-by":"publisher","first-page":"3886-3907","DOI":"10.3390\/ijerph10093886","article-title":"Pulmonary oxidative stress, inflammation and cancer: Respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms.","volume":"10","author":"A Valavanidis","year":"2013","journal-title":"Int J Environ Res Public Health."},{"key":"ref-41","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s13104-018-3425-3","article-title":"Paraquat induced acute kidney injury and lung fibrosis: A case report from Bangladesh.","volume":"11","author":"I Isha","year":"2018","journal-title":"BMC Res Notes."},{"key":"ref-42","doi-asserted-by":"publisher","first-page":"121-159","DOI":"10.4024\/11SA15R.jbpc.15.03","article-title":"Glyphosate, pathways to modern diseases IV: cancer and related pathologies.","volume":"15","author":"A Samsel","year":"2015","journal-title":"J Biol Phys Chem."},{"key":"ref-43","doi-asserted-by":"publisher","first-page":"490-491","DOI":"10.1016\/S1470-2045(15)70134-8","article-title":"Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate.","volume":"16","author":"K Guyton","year":"2015","journal-title":"Lancet Oncol."},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"49-54","DOI":"10.1289\/ehp.7340","article-title":"Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study.","volume":"113","author":"A de Roos","year":"2005","journal-title":"Environ Health Perspect."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"446-447","DOI":"10.1093\/jnci\/djx247","article-title":"Glyphosate Use and Cancer Incidence in the Agricultural Health Study: An Epidemiologic Perspective.","volume":"110","author":"E Ward","year":"2018","journal-title":"J Natl Cancer Inst."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"87-91","DOI":"10.1016\/0895-4356(90)90060-3","article-title":"Recall bias in epidemiologic studies.","volume":"43","author":"S Coughlin","year":"1990","journal-title":"J Clin Epidemiol."},{"key":"ref-47","doi-asserted-by":"publisher","first-page":"248-252","DOI":"10.1016\/S0140-6736(02)07451-2","article-title":"Bias and causal associations in observational research.","volume":"359","author":"D Grimes","year":"2002","journal-title":"Lancet."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/9-492\/v8\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-492\/v8\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-492\/v8\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T07:50:13Z","timestamp":1708415413000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/9-492\/v8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,4]]},"references-count":45,"URL":"https:\/\/doi.org\/10.12688\/f1000research.24114.8","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.160692.r247037","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.160692.r247037","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.160692.r247032","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,4]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/9-492\/v8#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.140396.r154761, Ann C Olsson, Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, 02 Nov 2022, version 6, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/9-492\/v6#referee-response-154761","order":0,"name":"referee-response-154761","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Chudchawal Juntarawijit<\/b>; \n<i>Posted: 23 May 2023<\/i>; \n<b>Response to reviewer<\/b>  \n<b>Reviewer's note:<\/b>&nbsp;\n<i>&quot;I have read the new version and I still have reservations for approving this paper for publication.&quot;  &quot;The minimum sample size was determined to be 229 for cases and 458 for controls using Kelsey\u2019s formula21 (unmatched population base case-control study). The assumptions used were as follows: proportion of case with pesticide exposure was 0.522, proportion of control with exposure was 0.423, and the ratio of case to control was 1:224.<\/i>  \n<i>Comment: The minimum sample size for what? This paragraph is missing something important such as \u201cThe minimum sample size to detect an OR of 1.5 was determined to be \u2026.\u201d&quot;<\/i>  \n<b>Response<\/b>: \n<b>First, we would like to thank you very much for your constructive comments and suggestions.  The statement has been revised as suggested. The new statement will be ... &quot;The minimum sample size to detect an OR of 1.6 was determined to be 215 for cases and 430 for controls based on Kelsey\u2019s formula...&quot;<\/b>  \n<b>Comment<\/b>: \n<i>&quot;The questionnaire on-line does not seem to be the one used for data collection because cooking fume and occupational air pollution is one question in the questionnaire and is reported separately in the table. The question regarding smoking in the questionnaire does not allow to calculate cumulative consumption. It seems that the authors \u201cupdated\u201d the questionnaire following my previous comments and this is not correct. The questionnaire should be the one actually used for the data collection.&quot;<\/i>  \n<b>Response<\/b>: \n<b>In the actual used questionnaire, information on exposure to cooking fumes and air pollution was collected using two separate questions. However, in the first version, the data were combined as a single variable when running the regression model so the questionnaire was changed according to the data.&nbsp; The problem occurs because we decided to use the original data as suggested by reviewers but not an updated the questionnaire. Concerning cigarette smoking, we actually had the data on number and duration to calculate cumulative consumption, but, in the first draft, the information was not used and thus was not included in the questionnaire. Sorry for not updating the questionnaire.<\/b>  \n<b>Comment<\/b>:\n<i> &quot;In \u201cDemographic information\u201d Cases and controls <b>do not<\/b> have similar cigarette smoking.&quot;<\/i>  \n<b>Response<\/b>: \n<b>Thank you for the notice. The error occurred because a new analysis using more detailed data on cigarette smoking yielded a higher smoking rate for cases, but we forgot to update the results. The mistake has been corrected by adding the following statement: &quot;...However, the cases had about twice the proportion of those who reported ever smoking a cigarette (23.6%) compared to the controls (13.6%). ...&quot;<\/b>  \n<b>Comment<\/b>: \n<i>&quot;The authors completely ignore co-exposures, i.e., are those exposed to \u201dx\u201d also exposed to \u201cy\u201d and \u201cz\u201d? If so, it is not possible to conclude that one agent is associated with lung cancer. There are several ways to address this, but difficult in a relatively small case-controlled study like this one.&quot;<\/i>  &nbsp;\n<b>Response<\/b>: \n<b>That is a great point. To find the potential effects of co-exposures, we decided to run a correlation matrix between those five individual pesticides with significant OR but found only paraquat and glyphosate to have a high correlation (correlation&nbsp;coefficients \u22650.30). However, these two pesticides did not have a significant OR with lung cancer, therefore the problem should not be a big concern.&nbsp;<\/b>","URL":"https:\/\/f1000research.com\/articles\/9-492\/v8#referee-comment-9696","order":1,"name":"referee-comment-9696","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.55470.r81706, Matthew R Bonner, Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, 26 Apr 2021, version 4, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/9-492\/v4#referee-response-81706","order":2,"name":"referee-response-81706","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Chudchawal Juntarawijit<\/b>; \n<i>Posted: 28 Apr 2021<\/i>; \n<b>Response to reviewer <\/b>  Comment: The conclusion that the significant associations observed for chlorpyrifos and carbofuran are consistent with the literature from other parts of the world seems to be inaccurate and inconsistent with the early discussion of these chemicals.  Response: First of all, we would like to thank you very much for your informative comments and suggestions. I and my Ph.D. student have learned a lot from you. Yes, we agree that the conclusion was inconsistent with the discussion. Therefore, it was amended as follows:  \n<b>Conclusion<\/b> This study found that the occurrence of lung cancer among people in Nakhon Sawan province, Thailand is associated with pesticide use. Out of 17 individual pesticides investigated, three insecticides (dieldrin, chlorpyrifos, and carbofuran), and two herbicides (glyphosate, and paraquat) were associated with incidences of lung cancer. These results were moderately supported by the literature. More studies are still required to confirm the results and to identify more individual pesticides that could cause lung cancer, as well as other types of cancer. These issues should receive more attention since these chemicals have been used widely.","URL":"https:\/\/f1000research.com\/articles\/9-492\/v8#referee-comment-6629","order":3,"name":"referee-comment-6629","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Chudchawal Juntarawijit<\/b>; \n<i>Posted: 17 Sep 2021<\/i>; Comment: The conclusion that the significant associations observed for chlorpyrifos and carbonfuran are consistent with the literature from other parts of the world seems to be inaccurate and inconsistent with the early discussion of these chemicals.  Response: Would you please clarify the point and suggest which statement should be revised and how to properly state it.","URL":"https:\/\/f1000research.com\/articles\/9-492\/v8#referee-comment-7158","order":4,"name":"referee-comment-7158","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.148634.r226247, Neela Guha, California Environmental Protection Agency, Sacramento, California, 23 Dec 2023, version 7, 3 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/9-492\/v7#referee-response-226247","order":5,"name":"referee-response-226247","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.160692.r247037, Md Sadique Hussain, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, 20 Feb 2024, version 8, indexed","URL":"https:\/\/f1000research.com\/articles\/9-492\/v8#referee-response-247037","order":6,"name":"referee-response-247037","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":7,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}