{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:51:03Z","timestamp":1787021463272,"version":"build-2736575974"},"update-to":[{"DOI":"10.12688\/f1000research.24567.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000}}],"reference-count":6,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Introduction:<\/ns3:bold>\n                    Propofol infusion syndrome (PRIS) is rare but a potentially lethal adverse event. The pathophysiologic mechanism is still unknown.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Patient concerns:<\/ns3:bold>\n                    A 22-year-old man was admitted for the treatment of Guillain-Barr\u00e9 syndrome. On day six, he required mechanical ventilation due to progressive muscle weakness; propofol (3.5 mg\/kg\/hour) was administered for five days for sedation. On day 13, he had hypotension with abnormal electrocardiogram findings, acute kidney injury, hyperkalemia and severe rhabdomyolysis.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Diagnosis and interventions:<\/ns3:bold>\n                    The patient was transferred to our intensive care unit (ICU) on suspicion of PRIS. Administration of noradrenaline and renal replacement therapy and fasciotomy for compartment syndrome of lower legs due to PRIS-rhabdomyolysis were performed.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Outcomes:<\/ns3:bold>\n                    The patient gradually recovered and was discharged from the ICU on day 30. On day 37, he had repeated sinus bradycardia with pericardial effusion in echocardiography. Cardiac\n                    <ns3:sup>18<\/ns3:sup>\n                    F-FDG PET on day 67 demonstrated heterogeneous\n                    <ns3:sup>18<\/ns3:sup>\n                    F-FDG uptake in the left ventricle. Electron microscopic investigation of endomyocardial biopsy on day 75 revealed mitochondrial myelinization of the cristae, which indicated mitochondrial damage of cardiomyocytes. He was discharged without cardiac abnormality on day 192.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusions:<\/ns3:bold>\n                    Mitochondrial damage in both morphological and functional aspects was observed in the present case. Sustained mitochondrial damage may be a therapeutic target beyond the initial therapy of discontinuing propofol administration.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.24567.2","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T10:45:45Z","timestamp":1642675545000},"page":"712","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Sustained mitochondrial damage in cardiomyocytes in patients with severe propofol infusion syndrome"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2686-2739","authenticated-orcid":false,"given":"Satoshi","family":"Karasawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-556X","authenticated-orcid":false,"given":"Taka-aki","family":"Nakada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9522-9518","authenticated-orcid":false,"given":"Naoto","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Daimon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"119-141","DOI":"10.1097\/00003246-200201000-00020","article-title":"Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult.","volume":"30","author":"J Jacobi","year":"2002","journal-title":"Crit Care Med."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1186\/s13054-015-1112-5","article-title":"Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports.","volume":"19","author":"A Kraj\u010dov\u00e1","year":"2015","journal-title":"Crit Care."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"606-607","DOI":"10.1016\/S0140-6736(00)04064-2","article-title":"Impaired fatty acid oxidation in propofol infusion syndrome.","volume":"357","author":"A Wolf","year":"2001","journal-title":"Lancet."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"87-90","DOI":"10.1016\/0006-2952(91)90684-w","article-title":"Influence of the anesthetic 2,6-diisopropylphenol on the oxidative phosphorylation of isolated rat liver 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declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}