{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:38Z","timestamp":1772168978900,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.24816.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000}}],"reference-count":5,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:italic>Cryptococcus neoformans<\/ns4:italic>\n                    infections occur mostly in immunodeficient individuals, being the most common opportunistic fungal central nervous system (CNS) infection in HIV seropositive patients. Moreover, other conditions affecting host immunity, such as hematologic malignancies, organ transplantation and immunosuppressive drugs are implicated as risk factors.\n                  <\/ns4:p>\n                  <ns4:p>The authors present a case of a 48-year-old male with Hodgkin Lymphoma for 26 years and submitted to several lines of treatment, diagnosed with cryptococcal meningitis while on therapy with brentuximab. The patient presented with positive cerebral spinal fluid (CSF) cryptococcal antigen plus positive blood cultures. He was put under induction antifungal treatment with liposomal amphotericin B and flucytosine, as well as corticosteroid therapy\u00a0with dexamethasone with headache improvement and a favorable clinical evolution.<\/ns4:p>\n                  <ns4:p>\n                    There are no reported cases of cryptococcal meningoencephalitis under CD30-directed monoclonal antibody. Furthermore, this case illustrates the risk of\n                    <ns4:italic>Cryptococcus neoformans<\/ns4:italic>\n                    infection in immunocompromising conditions other than HIV, underlining the need of considering this differential diagnosis when physicians face an opportunistic neuroinfection.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.24816.2","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T04:50:16Z","timestamp":1597207816000},"page":"687","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Cryptococcal meningitis in Hodgkin\u2019s Lymphoma patient receiving brentuximab-vedotin therapy"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-7039","authenticated-orcid":false,"given":"Tatiana","family":"Cunha Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1422-0974","authenticated-orcid":false,"given":"Rita","family":"Rb-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"F\u00e9lix Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Domingues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Mariz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"186-96","DOI":"10.1513\/pats.200907-063AL","article-title":"Cryptococcus.","volume":"7","author":"S Li","year":"2010","journal-title":"Proc Am Thorac Soc."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3390\/jof5030071","article-title":"Central nervous system cryptococcal infections in non-HIV infected patients.","volume":"5","author":"J Beardsley","year":"2019","journal-title":"J Fungi (Basel)."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"443-59","DOI":"10.1007\/s15010-018-1152-2","article-title":"Neuroinfections caused by fungi.","volume":"46","author":"K G\u00f3ralska","year":"2018","journal-title":"Infection."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"179-206","DOI":"10.1016\/j.idc.2015.10.006","article-title":"Cryptococcosis.","volume":"30","author":"E Mazlarz","year":"2016","journal-title":"Infect Dis Clin North Am."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"542-52","DOI":"10.1111\/myc.12496","article-title":"Cryptococcus neoformans infection in malignancy.","volume":"59","author":"S Schmalzle","year":"2016","journal-title":"Mycoses."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/9-687\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-687\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-687\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T05:45:22Z","timestamp":1600839922000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/9-687\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,12]]},"references-count":5,"URL":"https:\/\/doi.org\/10.12688\/f1000research.24816.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.28541.r69298","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.28541.r69298","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,12]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/9-687\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.27380.r66704, Adriana Roque, Clinical Hematology Department, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal, 20 Jul 2020, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/9-687\/v1#referee-response-66704","order":0,"name":"referee-response-66704","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.28541.r69298, Sarah A. Schmalzle, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA, 23 Sep 2020, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/9-687\/v2#referee-response-69298","order":1,"name":"referee-response-69298","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}