{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:43Z","timestamp":1772168983493,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.2546.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000}}],"reference-count":11,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Introduction:<\/ns4:bold>\n                    Hemolytic-uremic syndrome (HUS) is a leading cause of acute renal failure in infants and young children. It is traditionally defined as a triad of acute renal failure, hemolytic anemia and thrombocytopenia that occur within a week after prodromal hemorrhagic enterocolitis. Severe cases can also be presented by acute respiratory distress syndrome (ARDS), toxic megacolon with ileus, pancreatitis, central nervous system (CNS) disorders and multiple organ failure (MOF).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Case presentation:<\/ns4:bold>\n                    A previously healthy 4-year old Caucasian girl developed acute renal failure, thrombocytopenia and hemolytic anemia following a short episode of abdominal pain and bloody diarrhea. By the end of the first week the diagnosis of the typical HUS was established. During the second week the disease progressed into MOF that included ileus, pancreatitis, hepatitis, coma and ARDS, accompanied by hemodynamic instability and extreme leukocytosis. Nonetheless, the girl made a complete recovery after one month of the disease. She was successfully treated in the intensive care unit and significant improvement was noticed after plasmapheresis and continuous veno-venous hemodialysis.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    Early start of plasmapheresis and meticulous supportive treatment in the intensive care unit, including renal placement therapy, may be the therapy of choice in severe cases of HUS presented by MOF. Monitoring of prognostic factors is important for early performance of appropriate diagnostic and therapeutical interventions.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.2546.2","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T09:02:45Z","timestamp":1403254965000},"page":"79","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Severe form of hemolytic-uremic syndrome with multiple organ failure in a child: a case report"],"prefix":"10.12688","volume":"3","author":[{"given":"Dino","family":"Mijatovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Blagaic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeljko","family":"Zupan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2014,6,20]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"1035-50","DOI":"10.1681\/ASN.2004100861","article-title":"Hemolytic uremic syndrome.","volume":"16","author":"M Noris","year":"2005","journal-title":"J Am Soc Nephrol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"493-500","DOI":"10.1086\/341940","article-title":"Clinical course and the role of Shiga toxin-producing Escherichia coli infection in the hemolytic-uremic syndrome in pediatric patients, 1997\u20132000, in Germany and Austria: a prospective study.","volume":"186","author":"A Gerber","year":"2002","journal-title":"J Infect Dis."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"1155-64","DOI":"10.1100\/tsw.2007.172","article-title":"Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome.","volume":"7","author":"R Exeni","year":"2007","journal-title":"ScientificWorldJournal."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"1749-60","DOI":"10.1007\/s00467-008-0935-6","article-title":"Treatment and outcome of Shiga-toxin-associated hemolytic uremic syndrome (HUS).","volume":"23","author":"J Scheiring","year":"2008","journal-title":"Pediatr Nephrol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"604-609","DOI":"10.1182\/asheducation-2012.1.604","article-title":"Diagnostic and therapeutic challenges in the thrombotic thrombocytopenic purpura and hemolytic uremic syndromes.","volume":"2012","author":"J George","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"1656-62","DOI":"10.1542\/peds.2005-0785","article-title":"Predictors of fatality in postdiarrheal hemolytic uremic syndrome.","volume":"117","author":"R Oakes","year":"2006","journal-title":"Pediatrics."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"1218-28","DOI":"10.2215\/CJN.08921209","article-title":"Acute neurological involvement in diarrhea-associated hemolytic uremic syndrome.","volume":"5","author":"S Nathanson","year":"2010","journal-title":"Clin J Am Soc Nephrol."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"805-10","DOI":"10.1007\/s00247-004-1289-2","article-title":"CT and MRI in haemolytic uraemic syndrome with central nervous system involvement: distribution of lesions and prognostic value of imaging findings.","volume":"34","author":"M Steinborn","year":"2004","journal-title":"Pediatr Radiol."},{"key":"ref-9","doi-asserted-by":"crossref","first-page":"352-354","DOI":"10.1097\/00005176-200403000-00022","article-title":"Escherichia coli O157:H7\u2013associated hemolytic uremic syndrome and acute hepatocellular cholestasis: a case report.","volume":"38","author":"M Riley","year":"2004","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"10-19","DOI":"10.1111\/j.1744-9987.2010.00903.x","article-title":"Therapeutic apheresis in the treatment of hemolytic uremic syndrome in view of pathophysiological aspects.","volume":"15","author":"R Bambauer","year":"2011","journal-title":"Ther Apher Dial."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"1360-70","DOI":"10.1001\/jama.290.10.1360","article-title":"Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: A systematic review, meta-analysis, and meta-regression.","volume":"290","author":"A Garg","year":"2003","journal-title":"JAMA."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/3-79\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-79\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-79\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T15:00:57Z","timestamp":1543849257000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/3-79\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,20]]},"references-count":11,"URL":"https:\/\/doi.org\/10.12688\/f1000research.2546.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.4879.r5252","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.4879.r5239","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.4879.r5252","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.4879.r5239","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,20]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/3-79\/v2#article-reports","order":0,"name":"referee-status","label":"Referee 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work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}