{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:12:26Z","timestamp":1774278746069,"version":"3.50.1"},"reference-count":77,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Cough is a natural process that protects the airway. Cough can occur spontaneously or voluntarily. It is considered chronic when it is present for longer than 4 weeks in children or 8 weeks in adults. In both, chronic cough causes patient distress and increased healthcare utilization. Etiologies of pediatric chronic cough include asthma, protracted bacterial bronchitis, tracheomalacia, habit cough, and various systemic disorders. While some diagnoses are identifiable by careful history alone, others require testing guided by specific pointers. Flexible fiberoptic bronchoscopy has been an important tool to identify etiologies of chronic cough that were not otherwise apparent. In adults, asthma and bronchitis are well-defined etiologies of chronic cough, but much chronic cough in adults is largely a conundrum.<\/ns4:p><ns4:p>Reviews of adult chronic cough report that at least 40% of adults with chronic cough have no medical explanation. Gastroesophageal reflux and upper airway cough syndrome (a.k.a. post-nasal drip) have been common diagnoses of chronic cough, but those diagnoses have no support from controlled clinical trials and have been subjected to multiple published critiques. Cough hypersensitivity is considered to be an explanation for chronic cough in adults who have no other confirmed diagnosis. Gabapentin, a neuromodulator, has been associated with a modest effect in adults, as has speech pathology. While habit cough has not generally been a diagnosis in adults, there is evidence for a behavioral component in adults with chronic cough. Treatment for a specific diagnosis provides a better outcome than trials of cough suppression in the absence of a specific diagnosis. More data are needed for chronic cough in adults to examine the hypothesized cough hypersensitivity and behavioral management. This article reviews etiologies and the treatment of chronic cough in children and the conundrum of diagnosing and treating chronic cough in adults.<\/ns4:p>","DOI":"10.12688\/f1000research.25468.1","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T09:11:00Z","timestamp":1595409060000},"page":"757","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Diagnosis and management of chronic cough: similarities and differences between children and adults"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-2094","authenticated-orcid":false,"given":"Miles","family":"Weinberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2353-5687","authenticated-orcid":false,"given":"Manju","family":"Hurvitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"875-83","DOI":"10.1016\/j.chest.2016.12.025","article-title":"Use of Management Pathways or Algorithms in Children With Chronic Cough: CHEST Guideline and Expert Panel Report.","volume":"151","author":"A Chang","year":"2017","journal-title":"Chest."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1724-9","DOI":"10.1016\/j.jaip.2019.03.050","article-title":"Management of Cough.","volume":"7","author":"P Gibson","year":"2019","journal-title":"J Allergy Clin Immunol Pract."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"95-103","DOI":"10.2500\/aap.2014.35.3711","article-title":"Differential diagnosis of chronic cough in children.","volume":"35","author":"M Weinberger","year":"2014","journal-title":"Allergy Asthma Proc."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"22-30","DOI":"10.1183\/20734735.015216","article-title":"When is cough functional, and how should it be treated?.","volume":"13","author":"M Weinberger","year":"2017","journal-title":"Breathe (Sheff)."},{"key":"ref-5","first-page":"43-6","article-title":"Habit cough in adolescent children.","volume":"24","author":"B Berman","year":"1966","journal-title":"Ann Allergy."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"820-1","DOI":"10.1016\/j.chest.2019.06.024","article-title":"POINT: Is the Term Habit Cough an Inaccurate Use of a Term? Yes.","volume":"156","author":"T Pringsheim","year":"2019","journal-title":"Chest."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"512-6","DOI":"10.1002\/ppul.23948","article-title":"Habit-tic cough: Presentation and outcome with simple reassurance.","volume":"53","author":"M Wright","year":"2018","journal-title":"Pediatr Pulmonol."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"580-3","DOI":"10.1177\/000992286900801009","article-title":"Psychogenic Cough Tic in Children and Adolescents. Nine Case Histories Illustrate the Need for Re-Evaluation of This Common but Frequently Unrecognized Problem.","volume":"8","author":"H Kravitz","year":"2016","journal-title":"Clin Pediatr (Phila)."},{"key":"ref-9","first-page":"198-200","article-title":"'Honking': Psychogenic cough tic in children.","volume":"57","author":"E Weinberg","year":"1980","journal-title":"S Afr Med J."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"24-31","DOI":"10.1378\/chest.15-0423","article-title":"Somatic Cough Syndrome (Previously Referred to as Psychogenic Cough) and Tic Cough (Previously Referred to as Habit Cough) in Adults and Children: CHEST Guideline and Expert Panel Report.","volume":"148","author":"A Vertigan","year":"2015","journal-title":"Chest."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"930-1","DOI":"10.1016\/j.jaci.2015.09.002","article-title":"The cough without a cause: Habit cough syndrome.","volume":"137","author":"M Weinberger","year":"2016","journal-title":"J Allergy Clin Immunol."},{"key":"ref-12","doi-asserted-by":"crossref","first-page":"11-5","DOI":"10.1542\/peds.74.1.11","article-title":"The cough and the bedsheet.","volume":"74","author":"S Cohlan","year":"1984","journal-title":"Pediatrics."},{"key":"ref-13","first-page":"579-82","article-title":"Outcome of habit cough in children treated with a brief session of suggestion therapy.","volume":"67","author":"B Lokshin","year":"1991","journal-title":"Ann Allergy."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"535-7","DOI":"10.1002\/ppul.23979","article-title":"The habit cough: Diagnosis and treatment.","volume":"53","author":"M Weinberger","year":"2018","journal-title":"Pediatr Pulmonol."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"174-7","DOI":"10.1136\/bmj.38870.655405.AE","article-title":"Whooping cough in school age children with persistent cough: prospective cohort study in primary care.","volume":"333","author":"A Harnden","year":"2006","journal-title":"BMJ."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"631-50","DOI":"10.2217\/17455111.2.5.631","article-title":"Pediatric asthma and related allergic and nonallergic diseases: Patient-oriented evidence-based essentials that matter.","volume":"2","author":"M Weinberger","year":"2008","journal-title":"Pediatric Health."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"88-92","DOI":"10.1016\/j.jpeds.2011.06.049","article-title":"Protracted bacterial bronchitis in young children: Association with airway malacia.","volume":"160","author":"M Kompare","year":"2012","journal-title":"J Pediatr."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"1891-904","DOI":"10.1016\/S0140-6736(09)60327-5","article-title":"Cystic fibrosis.","volume":"373","author":"B O'Sullivan","year":"2009","journal-title":"Lancet."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"1136-40","DOI":"10.1136\/adc.2006.096958","article-title":"Primary ciliary dyskinesia: Current state of the art.","volume":"92","author":"A Bush","year":"2007","journal-title":"Arch Dis Child."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"866-79","DOI":"10.1016\/S0140-6736(18)31554-X","article-title":"Bronchiectasis in children: Diagnosis and treatment.","volume":"392","author":"A Chang","year":"2018","journal-title":"Lancet."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"943-50","DOI":"10.1378\/chest.11-2725","article-title":"A multicenter study on chronic cough in children: Burden and etiologies based on a standardized management pathway.","volume":"142","author":"A Chang","year":"2012","journal-title":"Chest."},{"key":"ref-22","first-page":"505-9","article-title":"Cough variant asthma: Usefulness of a diagnostic-therapeutic trial with prednisone.","volume":"69","author":"T Doan","year":"1992","journal-title":"Ann Allergy."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"686-698","DOI":"10.1016\/B978-0-7216-3695-5.50059-6","article-title":"Asthma in the pre-school child","author":"M Weinberger","year":"2012"},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"1375-84","DOI":"10.1016\/S0140-6736(08)60596-6","article-title":"Management of chronic cough.","volume":"371","author":"I Pavord","year":"2008","journal-title":"Lancet."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"i1-24","DOI":"10.1136\/thx.2006.065144","article-title":"Recommendations for the management of cough in adults.","volume":"61","author":"A Morice","year":"2006","journal-title":"Thorax."},{"key":"ref-26","article-title":"Global Strategy for Asthma Management and Prevention (2020 update) from the Global Initiative for Asthma"},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"387-8","DOI":"10.1016\/j.anai.2018.07.035","article-title":"Pediatric bronchial hyperresponsiveness and asthma phenotypes.","volume":"121","author":"M Weinberger","year":"2018","journal-title":"Ann Allergy Asthma Immunol."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"47-57","DOI":"10.1016\/j.ccm.2015.11.006","article-title":"Diagnosis of Adult Patients with Cystic Fibrosis.","volume":"37","author":"J Nick","year":"2016","journal-title":"Clin Chest Med."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"eS19-eS24","DOI":"10.1016\/S0929-693X(20)30046-4","article-title":"Current and future diagnosis of cystic fibrosis: Performance and limitations.","volume":"27","author":"T Bienvenu","year":"2020","journal-title":"Arch Pediatr."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"155-68","DOI":"10.3109\/2000-1967-010","article-title":"Transmission electron microscopy in the diagnosis of primary ciliary dyskinesia.","volume":"111","author":"G Roomans","year":"2006","journal-title":"Ups J Med Sci."},{"key":"ref-31","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1136\/bmj.2.4639.1269","article-title":"Kartagener's Syndrome.","volume":"2","author":"C Andrews","year":"1949","journal-title":"BMJ."},{"key":"ref-32","doi-asserted-by":"publisher","first-page":"e1-e12","DOI":"10.1513\/AnnalsATS.201904-347OT","article-title":"Nasal Nitric Oxide Measurement in Primary Ciliary Dyskinesia. A Technical Paper on Standardized Testing Protocols.","volume":"17","author":"A Shapiro","year":"2020","journal-title":"Ann Am Thorac Soc."},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"51-75","DOI":"10.3233\/TRD-190036","article-title":"Primary ciliary dyskinesia (PCD): A genetic disorder of motile cilia.","volume":"4","author":"M Leigh","year":"2019","journal-title":"Transl Sci Rare Dis."},{"key":"ref-34","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fped.2017.00196","article-title":"Editorial: Chronic Suppurative Lung Disease and Bronchiectasis in Children and Adolescents.","volume":"5","author":"K Eg","year":"2017","journal-title":"Front Pediatr."},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"1602139","DOI":"10.1183\/13993003.02139-2016","article-title":"ERS statement on protracted bacterial bronchitis in children.","volume":"50","author":"A Kantar","year":"2017","journal-title":"Eur Respir J."},{"key":"ref-36","doi-asserted-by":"publisher","first-page":"199-203","DOI":"10.1378\/chest.97.1.199","article-title":"Pitfalls in the use of the flexible bronchoscope in pediatric patients.","volume":"97","author":"R Wood","year":"1990","journal-title":"Chest."},{"key":"ref-37","doi-asserted-by":"publisher","first-page":"404-6","DOI":"10.1016\/s0022-3476(05)82833-1","article-title":"Localized tracheomalacia or bronchomalacia in children with intractable cough.","volume":"116","author":"R Wood","year":"1990","journal-title":"J Pediatr."},{"key":"ref-38","doi-asserted-by":"publisher","first-page":"144-6","DOI":"10.1002\/ppul.10121","article-title":"Unusual cause of chronic cough in a four-year-old cured by uvulectomy.","volume":"34","author":"A Najada","year":"2002","journal-title":"Pediatr Pulmonol."},{"key":"ref-39","doi-asserted-by":"publisher","first-page":"1147-1149","DOI":"10.1002\/ppul.20919","article-title":"Chronic cough and tonsillar hypertrophy: A case series.","volume":"43","author":"R Gurgel","year":"2008","journal-title":"Pediatr Pulmonol."},{"key":"ref-40","doi-asserted-by":"publisher","first-page":"1900382","DOI":"10.1183\/13993003.00382-2019","article-title":"ERS statement on tracheomalacia and bronchomalacia in children.","volume":"54","author":"C Wallis","year":"2019","journal-title":"Eur Respir J."},{"key":"ref-41","doi-asserted-by":"publisher","first-page":"286-94","DOI":"10.1002\/ppul.23231","article-title":"Mild tracheal compression by aberrant innominate artery and chronic dry cough in children.","volume":"51","author":"M Ghezzi","year":"2016","journal-title":"Pediatr Pulmonol."},{"key":"ref-42","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318121","article-title":"Cough and you'll miss it.","author":"S Molloy","year":"2019","journal-title":"Arch Dis Child Educ Pract Ed."},{"key":"ref-43","first-page":"17-8","article-title":"Arnold's nerve reflex; a little known cause of cough in pediatric patients.","volume":"115","author":"F Smith","year":"1963","journal-title":"J La State Med Soc."},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"e123-e125","DOI":"10.1093\/jpids\/pix044","article-title":"Treatment of Pertussis-2017.","volume":"7","author":"J Cherry","year":"2018","journal-title":"J Pediatric Infect Dis Soc."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"320-3","DOI":"10.1016\/s0022-3476(81)80671-3","article-title":"Comparative effects of antacids, enteric coating, and bile salts on the efficacy of oral pancreatic enzyme therapy in cystic fibrosis.","volume":"98","author":"E Nassif","year":"1981","journal-title":"J Pediatr."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"1612-1620","DOI":"10.1056\/NEJMoa1807120","article-title":"VX-445-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles.","volume":"379","author":"D Keating","year":"2018","journal-title":"N Engl J Med."},{"key":"ref-47","doi-asserted-by":"publisher","first-page":"585-592","DOI":"10.1093\/ejcts\/ezy076","article-title":"Aortopexy for the treatment of tracheobronchomalacia in 100 children: A 10-year single-centre experience.","volume":"54","author":"F Rijnberg","year":"2018","journal-title":"Eur J Cardiothorac Surg."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"e20170138","DOI":"10.1542\/peds.2017-0138","article-title":"Airway Autoimmune Inflammatory Response (AAIR) Syndrome: An Asthma-Autoimmune Overlap Disorder?","volume":"141","author":"C Spencer","year":"2018","journal-title":"Pediatrics."},{"key":"ref-49","doi-asserted-by":"publisher","first-page":"633-7","DOI":"10.1056\/NEJM197903223001201","article-title":"Chronic Cough as the Sole Presenting Manifestation of Bronchial Asthma.","volume":"300","author":"W Corrao","year":"1979","journal-title":"N Engl J Med."},{"key":"ref-50","doi-asserted-by":"publisher","first-page":"196-209","DOI":"10.1016\/j.chest.2017.10.016","article-title":"Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report.","volume":"153","author":"R Irwin","year":"2018","journal-title":"Chest."},{"key":"ref-51","doi-asserted-by":"publisher","first-page":"292-6","DOI":"10.1136\/archdischild-2017-312890","article-title":"Respiratory manifestations of gastro-oesophageal reflux in children.","volume":"103","author":"F de Benedictis","year":"2018","journal-title":"Arch Dis Child."},{"key":"ref-52","doi-asserted-by":"publisher","first-page":"31-5","DOI":"10.1016\/j.prrv.2005.11.005","article-title":"Does post-nasal drip cause cough in childhood?","volume":"7","author":"A Kemp","year":"2006","journal-title":"Paediatr Respir Rev."},{"key":"ref-53","doi-asserted-by":"publisher","first-page":"343-5","DOI":"10.1016\/j.pupt.2004.09.005","article-title":"Post-nasal drip syndrome\u2014a symptom to be sniffed at?","volume":"17","author":"A Morice","year":"2004","journal-title":"Pulm Pharmacol Ther."},{"key":"ref-54","doi-asserted-by":"publisher","first-page":"105-20","DOI":"10.1016\/j.gtc.2013.11.007","article-title":"Extraesophageal presentations of GERD: Where is the science?","volume":"43","author":"R Madanick","year":"2014","journal-title":"Gastroenterol Clin North Am."},{"key":"ref-55","first-page":"270-3","article-title":"\"Post-nasal drip syndrome\": Most patients with purulent nasal secretions do not complain of chronic cough.","volume":"44","author":"J O'Hara","year":"2006","journal-title":"Rhinology."},{"key":"ref-56","doi-asserted-by":"publisher","first-page":"195-203","DOI":"10.4193\/Rhin14.210","article-title":"Simulated postnasal mucus fails to reproduce the symptoms of postnasal drip in rhinitics but only in healthy subjects.","volume":"53","author":"J Rimmer","year":"2015","journal-title":"Rhinology."},{"key":"ref-57","doi-asserted-by":"publisher","first-page":"794-9","DOI":"10.1016\/S1081-1206(10)61341-5","article-title":"Long-term outcome of vocal cord dysfunction.","volume":"96","author":"D Doshi","year":"2006","journal-title":"Ann Allergy Asthma Immunol."},{"key":"ref-58","doi-asserted-by":"publisher","first-page":"74-9","DOI":"10.1136\/dtb.2018.000014","article-title":"Chronic cough: A practical approach to assessment and management.","volume":"57","author":"A Mathur","year":"2019","journal-title":"Drug Ther Bull."},{"key":"ref-59","doi-asserted-by":"publisher","first-page":"1901136","DOI":"10.1183\/13993003.01136-2019","article-title":"ERS guidelines on the diagnosis and treatment of chronic cough in adults and children.","volume":"55","author":"A Morice","year":"2020","journal-title":"Eur Res J."},{"key":"ref-60","doi-asserted-by":"publisher","first-page":"1544-51","DOI":"10.1056\/NEJMcp1414215","article-title":"Chronic Cough.","volume":"375","author":"J Smith","year":"2016","journal-title":"N Engl J Med."},{"key":"ref-61","doi-asserted-by":"publisher","first-page":"1132-48","DOI":"10.1183\/09031936.00218613","article-title":"Expert opinion on the cough hypersensitivity syndrome in respiratory medicine.","volume":"44","author":"A Morice","year":"2014","journal-title":"Eur Res J."},{"key":"ref-62","doi-asserted-by":"publisher","first-page":"199-201","DOI":"10.1183\/09031936.03.00066403","article-title":"Chronic tonsillar enlargement and cough: Preliminary evidence of a novel and treatable cause of chronic cough.","volume":"23","author":"S Birring","year":"2004","journal-title":"Eur Res J."},{"key":"ref-63","first-page":"229","article-title":"Hypertrophic lingual tonsils and cough.","volume":"144","author":"J Lehrer","year":"1986","journal-title":"West J Med."},{"key":"ref-64","doi-asserted-by":"publisher","first-page":"984-1005","DOI":"10.1378\/chest.127.3.984","article-title":"Tracheomalacia and Tracheobronchomalacia in Children and Adults: An In-Depth Review.","volume":"127","author":"K Carden","year":"2005","journal-title":"Chest."},{"key":"ref-65","doi-asserted-by":"publisher","first-page":"C1-C3","DOI":"10.1111\/j.1525-1497.2005.00224.x","article-title":"An Unusual Cause of Chronic Cough. Foreign Body Aspiration.","volume":"21","author":"L Willett","year":"2006","journal-title":"J Gen Intern Med."},{"key":"ref-66","doi-asserted-by":"publisher","first-page":"129-33","DOI":"10.1378\/chest.112.1.129","article-title":"Foreign body aspiration into the lower airway in Chinese adults.","volume":"112","author":"C Chen","year":"1997","journal-title":"Chest."},{"key":"ref-67","doi-asserted-by":"publisher","first-page":"e143-e144","DOI":"10.1016\/j.amjmed.2016.11.026","article-title":"Foreign Body in External Ear Canal: An Unusual Cause of Chronic Cough.","volume":"130","author":"K Gold","year":"2017","journal-title":"Am J Med."},{"key":"ref-68","doi-asserted-by":"publisher","first-page":"467-97","DOI":"10.1016\/j.chest.2017.11.018","article-title":"Cough Due to TB and Other Chronic Infections: CHEST Guideline and Expert Panel Report.","volume":"153","author":"S Field","year":"2018","journal-title":"Chest."},{"key":"ref-69","doi-asserted-by":"publisher","first-page":"954-5","DOI":"10.1177\/019459989310900529","article-title":"An Elongated Uvula Producing Chronic Cough.","volume":"109","author":"F Miller","year":"1993","journal-title":"Otolaryngol Head Neck Surg."},{"key":"ref-70","doi-asserted-by":"publisher","first-page":"1007-8","DOI":"10.1002\/lary.26393","article-title":"Are neuromodulating medications effective for the treatment of chronic neurogenic cough?","volume":"127","author":"J Giliberto","year":"2017","journal-title":"Laryngoscope."},{"key":"ref-71","doi-asserted-by":"publisher","first-page":"1583-9","DOI":"10.1016\/S0140-6736(12)60776-4","article-title":"Gabapentin for refractory chronic cough: A randomised, double-blind, placebo-controlled trial.","volume":"380","author":"N Ryan","year":"2012","journal-title":"Lancet."},{"key":"ref-72","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30471-0","article-title":"Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: A randomised, double-blind, controlled, parallel-group, phase 2b trial.","author":"J Smith","year":"2020","journal-title":"Lancet Respir Med."},{"key":"ref-73","doi-asserted-by":"publisher","first-page":"129-36","DOI":"10.1136\/thoraxjnl-2016-208843","article-title":"Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: A multicentre randomised control trial.","volume":"72","author":"S Chamberlain Mitchell","year":"2017","journal-title":"Thorax."},{"key":"ref-74","article-title":"Mandel Sher related to a discussion of similarities between neurogenic cough in adults and habit cough in children"},{"key":"ref-75","doi-asserted-by":"publisher","first-page":"515-6","DOI":"10.1016\/j.anai.2019.08.011","article-title":"Unexpected and unintended cure of habit cough by proxy.","volume":"123","author":"M Weinberger","year":"2019","journal-title":"Ann Allergy Asthma Immunol."},{"key":"ref-76","doi-asserted-by":"publisher","first-page":"8-9","DOI":"10.1056\/NEJMp1504023","article-title":"Placebo Effects in Medicine.","volume":"373","author":"T Kaptchuk","year":"2015","journal-title":"N Engl J Med."},{"key":"ref-77","article-title":"Habitual cough, in The Spirit of Diseases.","author":"F Mercuruis"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/9-757\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-757\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-757\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T22:39:10Z","timestamp":1667515150000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/9-757\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":77,"URL":"https:\/\/doi.org\/10.12688\/f1000research.25468.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.28105.r67241","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.28105.r67239","asserted-by":"subject"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,22]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/9-757\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.28105.r67239, Woo-Jung Song, Department of Allergy and Clinical Immunology, Airway Sensation and Cough Research Laboratory, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, 23 Jul 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-757\/v1#referee-response-67239","order":0,"name":"referee-response-67239","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.28105.r67241, Rafa\u0142 Krenke, Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland, 23 Jul 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-757\/v1#referee-response-67241","order":1,"name":"referee-response-67241","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}