{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:10:42Z","timestamp":1791465042470,"version":"4.3.4"},"update-to":[{"DOI":"10.12688\/f1000research.25713.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000}}],"reference-count":39,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Vitiligo is a disease of mysterious origins in the context of its occurrence and pathogenesis. The autoinflammatory theory is perhaps the most widely accepted theory that discusses the occurrence of Vitiligo. The theory elaborates the clinical association of vitiligo with autoimmune disorders such as Psoriasis, Multiple Sclerosis and Rheumatoid Arthritis and Diabetes. In the present work, we discuss the comprehensive set of differentially co-expressed genes involved in the crosstalk events between Vitiligo and associated autoimmune disorders (Psoriasis, Multiple Sclerosis and Rheumatoid Arthritis). We progress our previous tool, Vitiligo Information Resource (VIRdb), and incorporate into it a compendium of Vitiligo-related multi-omics datasets and present it as VIRdb 2.0. It is available as a web-resource consisting of statistically sound and manually curated information. VIRdb 2.0 is an integrative database as its datasets are connected to KEGG, STRING, GeneCards, SwissProt, NPASS. Through the present study, we communicate the major updates and expansions in the VIRdb and deliver the new version as VIRdb 2.0. VIRdb 2.0 offers the maximum user interactivity along with ease of navigation. We envision that VIRdb 2.0 will be pertinent for the researchers and clinicians engaged in drug development for vitiligo.<\/ns3:p>","DOI":"10.12688\/f1000research.25713.2","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T07:55:18Z","timestamp":1612166118000},"page":"1055","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["VIRdb 2.0: Interactive analysis of comorbidity conditions associated with vitiligo pathogenesis using co-expression network-based approach"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2618-5296","authenticated-orcid":false,"given":"Priyansh","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehak","family":"Talwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alakto","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7099-5750","authenticated-orcid":false,"given":"Sabyasachi","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-7058","authenticated-orcid":false,"given":"Samuel","family":"Bharti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-654X","authenticated-orcid":false,"given":"Priyanka","family":"Narad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-3675","authenticated-orcid":false,"given":"Abhishek","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"153-172","DOI":"10.2310\/7750.2012.12005","article-title":"The Pathogenesis of Vitiligo.","volume":"17","author":"N Malhotra","year":"2013","journal-title":"J Cutan Med Surg."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3389\/fendo.2018.00197","article-title":"Neural and Endocrine Pathobiochemistry of Vitiligo: Comparative Study for a Hypothesized Mechanism.","volume":"9","author":"M Kotb El-Sayed","year":"2018","journal-title":"Front Endocrinol (Lausanne)."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"42394","DOI":"10.1038\/srep42394","article-title":"Dysregulated autophagy increased melanocyte sensitivity to H2O2-induced oxidative stress in vitiligo.","volume":"7","author":"Y He","year":"2017","journal-title":"Sci Rep."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"405268","DOI":"10.5402\/2012\/405268","article-title":"The Newest Hypothesis about Vitiligo: Most of the Suggested Pathogenesis of Vitiligo Can Be Attributed to Lack of One Factor, Zinc-\u03b1 2-Glycoprotein.","volume":"2012","author":"N Bagherani","year":"2012","journal-title":"ISRN Dermatol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s41702-018-0030-y","article-title":"Exploring vitiligo susceptibility and management: a brief review.","volume":"2","author":"R Rahman","year":"2018","journal-title":"Biomedical Dermatology."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"41-47","DOI":"10.1034\/j.1600-0749.13.s8.9.x","article-title":"Intrinsic and Extrinsic Pathomechanisms in Vitiligo.","volume":"13","author":"A Taieb","year":"2000","journal-title":"Pigment Cell Res."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"74-84","DOI":"10.1016\/S0140-6736(14)60763-7","article-title":"Vitiligo.","volume":"386","author":"K Ezzedine","year":"2015","journal-title":"Lancet."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"269-275","DOI":"10.1159\/000247164","article-title":"Vitiligo and Other Diseases: Coexistence or True Association? 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.54266.r78583, Dinesh Gupta, Translational Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, Delhi, India, 11 Mar 2021, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/9-1055\/v2#referee-response-78583","order":0,"name":"referee-response-78583","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.28377.r75389, Rasheedunnisa Begum, Mitesh Dwivedi, Department of Biochemistry, Faculty of Science, Maharaja Sayajirao University of Baroda, Vadodara, Gujurat, India, 04 Jan 2021, version 1, 3 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/9-1055\/v1#referee-response-75389","order":1,"name":"referee-response-75389","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.28377.r75274, Animesh A Sinha, Department of Dermatology, University at Buffalo, The State University of New York, Buffalo, NY, USA, 11 Jan 2021, version 1, 3 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/9-1055\/v1#referee-response-75274","order":2,"name":"referee-response-75274","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Abhishek Sengupta<\/b>; \n<i>Posted: 27 Jan 2021<\/i>; Dear Sir, We thank you for the generous and concise comments on our manuscript. We have incorporated the suggestions and changes have been added to the manuscript text also. Q.1 Intro: the Specific goals of the study and the previous work by the authors relevant to this study should be further explained. \n<b>As per the suggestion, we have incorporated a few lines about the specific goals of the study as well as the explained our previous work briefly. We have given the reference to our previously published paper to be explored in more detail. <\/b> Q.2 It is not clear that all published and available datasets for VL and the other autoimmune diseases have been incorporated into the program.&nbsp; A Table of all relevant studies should be provided in the manuscript or supplemental data. \n<b>We have mentioned in our previous paper the dataset that was used for Vitiligo and the inclusion and exclusion criterion for all the available datasets. To briefly answer your question, Gene Expression Omnibus was manually queried using \u201c(\u201cvitiligo\u201d (MeSH Terms) OR vitiligo (All Fields)) AND (\u201chumans\u201d (MeSH Terms) OR \u201cHomo sapiens\u201d (Organism) OR homo sapiens (All Fields))\u201d. The returned results were manually curated for microarray experiments having healthy controls against affected individuals only for both the VL and other autoimmune diseases that we have considered in our work. As no plausible Our primary focus was on microarray data and no plausible data was available having an adequate amount of data for analysis so other autoimmune diseases were excluded. We aim to work on more data and include more information in the further prospects of this project.<\/b> Q.3 The site itself would benefit from tutorials and a better search function. \n<b>&nbsp;A short tutorial has been incorporated at the Home page highlighting the sections and the process of retrieval from the sections. Complete code for accessing the database is already available at GitHub. A new page has been created to highlight &quot;what's new in this release&quot;.<\/b> Q.4 Some more extensive data on disease intersecting genes and functional pathways should be included. \n<b>A network gallery is available under the \u201cBrowse Section\u201d. The visualization of the network of the intersecting genes with D3-Fore is available. These networks have been generated using GeneMania plugin from Cytoscape. Further, the analysis was also done to elaborate the Gene Ontology for the intersecting DEGs, the data is available in Appendix-VI. Further, we aim to build more towards the on this in our future studies. ADMET studies have also been included.<\/b>","URL":"https:\/\/f1000research.com\/articles\/9-1055\/v2#referee-comment-6308","order":3,"name":"referee-comment-6308","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}