{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:44:02Z","timestamp":1789627442216,"version":"build-2803163510"},"update-to":[{"DOI":"10.12688\/f1000research.2642.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T00:00:00Z","timestamp":1434672000000}}],"reference-count":6,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T00:00:00Z","timestamp":1434672000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    We report a unique case of a woman with Channelopathy-associated Insensitivity to Pain (CIP) Syndrome, who developed features of neuropathic pain after sustaining pelvic fractures and an epidural hematoma that impinged on the right fifth lumbar (L5) nerve root. Her pelvic injuries were sustained during painless labor, which culminated in a Cesarean section. She had been diagnosed with CIP as child, which was later confirmed when she was found to have null mutations of the\n                    <ns4:italic>SCN9A<\/ns4:italic>\n                    \u00a0gene that encodes the voltage-gated sodium channel Nav1.7. She now complains of troubling continuous buzzing in both legs and a vice-like squeezing in the pelvis on walking. Quantitative sensory testing showed that sensory thresholds to mechanical stimulation of the dorsum of both feet had increased more than 10-fold on both sides compared with tests performed before her pregnancy. These findings fulfill the diagnostic criteria for neuropathic pain. Notably, she mostly only experiences the negative symptoms (such as numbness and tingling, but also electric shocks), and she has not reported sharp or burning sensations, although the value of verbal descriptors is somewhat limited in a person who has never felt pain before. However, her case strongly suggests that at least some of the symptoms of neuropathic pain can persist despite the absence of the Nav1.7 channel. Pain is a subjective experience and this case sheds light on the transmission of neuropathic pain in humans that cannot be learned from knockout mice.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.2642.2","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T10:20:07Z","timestamp":1434709207000},"page":"135","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Case Report: Neuropathic pain in a patient with congenital insensitivity to pain"],"prefix":"10.12688","volume":"3","author":[{"given":"Daniel W.","family":"Wheeler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Katherine","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Geoffrey","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2015,6,19]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"196-207","DOI":"10.1111\/j.1749-6632.2009.05110.x","article-title":"Familial pain syndromes from mutations of the NaV1.7 sodium channel.","volume":"1184","author":"T Fischer","year":"2010","journal-title":"Ann N Y Acad Sci."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"894-8","DOI":"10.1038\/nature05413","article-title":"An SCN9A channelopathy causes congenital inability to experience pain.","volume":"444","author":"J Cox","year":"2006","journal-title":"Nature."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"1630-5","DOI":"10.1212\/01.wnl.0000282763.29778.59","article-title":"Neuropathic pain: redefinition and a grading system for clinical and research purposes.","volume":"70","author":"R Treede","year":"2008","journal-title":"Neurology."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"203-12","DOI":"10.1016\/j.neuron.2008.11.023","article-title":"Can we share a pain we never felt? Neural correlates of empathy in patients with congenital insensitivity to pain.","volume":"61","author":"N Danziger","year":"2009","journal-title":"Neuron."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"29-36","DOI":"10.1016\/j.pain.2004.12.010","article-title":"Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4).","volume":"114","author":"D Bouhassira","year":"2005","journal-title":"Pain."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1744-8069-1-24","article-title":"Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.","volume":"1","author":"M Nassar","year":"2005","journal-title":"Mol Pain."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/3-135\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-135\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-135\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T07:35:24Z","timestamp":1543995324000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/3-135\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,19]]},"references-count":6,"URL":"https:\/\/doi.org\/10.12688\/f1000research.2642.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.7158.r9122","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.7158.r9123","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.7158.r9123","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.7158.r9122","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726023310.793524627","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,19]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/3-135\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.7158.r9122, Frank van Eijs, Department of Anaesthesiology, St. Elisabeth Hospital, Tilburg, The Netherlands, 22 Jun 2015, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/3-135\/v2#referee-response-9122","order":0,"name":"referee-response-9122","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.7158.r9123, Juan D. Ramirez, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK, 29 Jul 2015, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/3-135\/v2#referee-response-9123","order":1,"name":"referee-response-9123","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"},{"value":"Halina Machelska, Pain: Basic Science DOI: 10.3410\/f.726023310.793524627","URL":"http:\/\/f1000.com\/prime\/726023310#eval793524627","order":0,"name":"recommendation-793524627","label":"Recommendation","group":{"name":"prime-recommendations","label":"F1000Prime article recommendations"}}]}}