{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:39:37Z","timestamp":1785929977831,"version":"3.56.0"},"update-to":[{"DOI":"10.12688\/f1000research.26438.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000}}],"reference-count":21,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Metastatic tumors of the heart presenting with complete heart block (CHB) is an extremely uncommon case. There are no available guidelines in managing CHB in terminal cancer. Permanent pacemaker implantation in such cases is a challenge in terms of clinical utility and palliative care.<\/ns4:p>\n                  <ns4:p>We report a case of a 24-year-old man suffering from tongue cancer presenting with CHB. An intracardiac mass and moderate pericardial effusion were present, presumed as the metastatic tumor of tongue cancer. We implanted a temporary pacemaker for his symptomatic heart block and cardiogenic shock, and pericardiocentesis for his massive pericardial effusion. We decided that a permanent pacemaker would not be implanted based on the low survival rate and significant comorbidities.<\/ns4:p>\n                  <ns4:p>Multiple studies report a variable number of cardiac metastasis incidence ranging from 2.3% to 18.3%. It is rare for such malignancies to present with CHB. The decision to implant a permanent pacemaker is highly specific based on the risks and benefits of each patient. It needs to be tailored to the patient\u2019s functional status, comorbid diseases, prognosis, and response to conservative management.<\/ns4:p>","DOI":"10.12688\/f1000research.26438.2","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T04:50:08Z","timestamp":1605070208000},"page":"1243","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: Complete heart block as a manifestation of cardiac metastasis of oral cancer"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7834-344X","authenticated-orcid":false,"given":"Andrianto","family":"Andrianto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-7743","authenticated-orcid":false,"given":"Eka Prasetya Budi","family":"Mulia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denny","family":"Suwanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dita Aulia","family":"Rachmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4372-6875","authenticated-orcid":false,"given":"Mohammad","family":"Yogiarto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"1790-1794","DOI":"10.1161\/CIRCULATIONAHA.112.000790","article-title":"Tumors Metastatic to the Heart.","volume":"128","author":"A Goldberg","year":"2014","journal-title":"Circulation."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"yty131","DOI":"10.1093\/ehjcr\/yty131","article-title":"A case report: metastatic complete heart block.","volume":"2","author":"D Kumar","year":"2018","journal-title":"Eur Heart J Case Rep."},{"key":"ref-3","doi-asserted-by":"crossref","first-page":"657-661","DOI":"10.1161\/01.CIR.24.3.657","article-title":"Complete Atrioventricular Block due to Cardiac Metastasis of Bronchogenic Carcinoma.","volume":"24","author":"G Buckberg","year":"1961","journal-title":"Circulation."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"260-263","DOI":"10.4070\/kcj.2016.46.2.260","article-title":"Cardiac metastasis of leiomyosarcoma complicated with complete atrio-ventricular block and ventricular tachycardia.","volume":"46","author":"Y Park","year":"2016","journal-title":"Korean Circ J."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"91-95","DOI":"10.3892\/mco.2016.1091","article-title":"Cardiac metastasis of squamous cell carcinoma of the thyroid gland with severe disseminated intravascular coagulation: A case report.","volume":"6","author":"T Yoshihiro","year":"2017","journal-title":"Mol Clin Oncol."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"1569-1572","DOI":"10.1378\/chest.06-1904","article-title":"Cardiac metastasis from lung adenocarcinoma causing atrioventricular block and left ventricular outflow tract obstruction.","volume":"131","author":"T Kasai","year":"2007","journal-title":"Chest."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12872-018-0876-3","article-title":"Complete atrioventricular block as an initial manifestation of recurred oral cavity cancer\u202f: a case report.","volume":"18","author":"J Cho","year":"2018","journal-title":"BMC Cardiovasc Disord."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"201-202","DOI":"10.1046\/j.1540-8175.2003.03001.x","article-title":"Massive metastatic intracardiac lymphoma presenting with complete heart block with resolution following chemotherapy.","volume":"20","author":"S Clifford","year":"2003","journal-title":"Echocardiography."},{"key":"ref-9","first-page":"931-932","article-title":"A complete atrioventricular block secondary to myocardial metastases of lung cancer . A case report.","volume":"6","author":"D Mocini","year":"2005","journal-title":"Ital Hear J."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"e104-7","DOI":"10.1590\/s0066-782x2006001700025","article-title":"Metastatic Tumor of Squamous Cell Carcinoma From Uterine Cervix to Heart: Ante-Mortem Diagnosis.","volume":"87","author":"J Ferraz","year":"2006","journal-title":"Arq Bras Cardiol."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"545-548","DOI":"10.1093\/europace\/eul058","article-title":"Cardiac metastasis of malignant melanoma\u202f: a rare cause of complete atrioventricular block.","volume":"8","author":"N Ozyuncu","year":"2006","journal-title":"Europace."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"687-690","DOI":"10.1007\/s00277-007-0290-x","article-title":"A case of complete heart block reverting to normal sinus rhythm after treatment for cardiac invasive Burkitt\u2019s lymphoma.","volume":"86","author":"J Knowles","year":"2007","journal-title":"Ann Hematol."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1532-429X-10-37","article-title":"Cardiovascular magnetic resonance of the charcoal heart.","volume":"10","author":"V Rathi","year":"2008","journal-title":"J Cardiovasc Magn Reson."},{"key":"ref-14","first-page":"34-35","article-title":"Complete Heart Block in a Patient With Metastatic Papillary Thyroid Carcinoma.","volume":"32","author":"C Lin","year":"2015","journal-title":"Fed Pract."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"1075-1081","DOI":"10.1002\/ccr3.695","article-title":"A case of gingival cancer with pulmonary metastases that developed complete atrioventricular block and ventricular fibrillation as a result of myocardial metastases.","volume":"4","author":"T Yoneda","year":"2016","journal-title":"Clin Case Rep."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"27-34","DOI":"10.1136\/jcp.2005.035105","article-title":"Cardiac metastases.","volume":"60","author":"R Bussani","year":"2007","journal-title":"J Clin Pathol."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"764-772","DOI":"10.2214\/AJR.16.16148","article-title":"Metastasis to the Heart: A Radiologic Approach to Diagnosis With Pathologic Correlation.","volume":"207","author":"J Lichtenberger","year":"2016","journal-title":"AJR Am J Roentgenol."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.rec.2013.11.003","article-title":"2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy.","volume":"67","author":"M Brignole","year":"2014","journal-title":"Rev Esp Cardiol (Engl Ed)."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"e382-e482","DOI":"10.1161\/CIR.0000000000000628","article-title":"2018 ACC\/AHA\/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.","volume":"140","author":"F Kusumoto","year":"2019","journal-title":"Circulation."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"989-996","DOI":"10.1002\/cam4.619","article-title":"Role of palliative radiotherapy in the management of mural cardiac metastases: who when and how to treat? A case series of 10 patients.","volume":"5","author":"A Fotouhi Ghiam","year":"2016","journal-title":"Cancer Med."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"479-491","DOI":"10.1093\/europace\/euv135","article-title":"Radiotherapy in patients with pacemakers and implantable cardioverter defibrillators: A literature review.","volume":"18","author":"T Zaremba","year":"2016","journal-title":"Europace."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/9-1243\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-1243\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-1243\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T10:46:25Z","timestamp":1605782785000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/9-1243\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,11]]},"references-count":21,"URL":"https:\/\/doi.org\/10.12688\/f1000research.26438.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.30564.r74285","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.30564.r74597","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.30564.r74597","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.30564.r74285","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,11]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/9-1243\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.30564.r74597, Radityo Prakoso, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, 19 Nov 2020, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/9-1243\/v2#referee-response-74597","order":0,"name":"referee-response-74597","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.30564.r74285, Pieter A.F.M. Doevendans, Department of Cardiology, Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands, 19 Nov 2020, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/9-1243\/v2#referee-response-74285","order":1,"name":"referee-response-74285","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}