{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:39:59Z","timestamp":1773016799234,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.26627.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000}}],"reference-count":29,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Princess Nourah bint Abdulrahman University"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>This report describes a clinical case of asymptomatic compound odontoma in the anterior left side of the maxilla associated with an impacted canine and supernumerary tooth with a gubernacular canal of a 47- year-old female with no relevant medical history. Cone-beam computed tomography (CBCT) was performed for precise three-dimensional localization of each structure and assessment of their spatial relationship with the associated structures before surgery. The treatment protocol involved surgical enucleation of the odontoma and open extraction of both impacted and supernumerary teeth. The patient had uneventful healing and proceeded with the prosthodontic treatment plan.<\/ns3:p>\n                  <ns3:p>The dentist should be aware of the probability of a close relationship between the development of odontoma and presence of the gubernacular tract, which could be used as a future radiographic diagnostic criterion of an odontoma. Also, we recommend that more studies be performed in this field to deeply analyze the imaging characteristics of GT and its spatial association with various pathological lesions in the future.<\/ns3:p>","DOI":"10.12688\/f1000research.26627.2","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T09:05:09Z","timestamp":1614330309000},"page":"1204","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: An association of the gubernacular canal, supernumerary tooth and odontoma with an impacted canine on cone-beam computed tomography"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8184-7443","authenticated-orcid":false,"given":"Lubna K.","family":"Elsayed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1570-4524","authenticated-orcid":false,"given":"Sara M.","family":"El Khateeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzan A.","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shatha Subhi","family":"ALHarthi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-519X","authenticated-orcid":false,"given":"Raidan","family":"Ba-Hattab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"ref-1","first-page":"47-52","article-title":"Odontoma associated with supernumerary and impacted 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odontoma.","volume":"86","author":"M Kaneko","year":"1998","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"ref-6","article-title":"Shafer\u2019S Textbook Of Oral Pathology (6th Edition)","author":"R Rajendran"},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"755-758","DOI":"10.1097\/SCS.0000000000003433","article-title":"Association Between Odontoma and Impacted Teeth.","volume":"28","author":"G Isola","year":"2017","journal-title":"J Craniofac Surg."},{"key":"ref-8","article-title":"Contemporary Oral and Maxillofacial Surgery","author":"J Hupp","year":"2018"},{"key":"ref-9","first-page":"423-428","article-title":"The gubernaculum dentis.","volume":"21","author":"J Hodson","year":"1971","journal-title":"Dent Pract Dent Rec."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"189-200","DOI":"10.1111\/j.1600-0714.1980.tb00377.x","article-title":"Tooth eruption: evidence for the central role of the dental follicle.","volume":"9","author":"D Cahill","year":"1980","journal-title":"J Oral Pathol."},{"key":"ref-11","first-page":"5","article-title":"Gubernacular cord and canal \u2013 does these anatomical structures play a role in dental eruption","author":"D Ferreira"},{"key":"ref-12","first-page":"12","article-title":"Compound Odontoma Associated with Impacted Teeth: A Case Report","volume":"1","author":"P Choudhary","year":"2014"},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"169-173","DOI":"10.3329\/bjms.v19i1.43892","article-title":"Management of bilateral impacted maxillary canines (BIMC): open surgical exposure and orthodontic traction.","volume":"19","author":"M Alam","year":"2019","journal-title":"Bangladesh J Med Sci."},{"key":"ref-14","first-page":"18-23","article-title":"Odontoma Compound Preventing Dental Irruption and Start of Orthodontic Treatment: Case Report.","volume":"17","author":"S Silva Dos Santos","year":"2016","journal-title":"Braz J Surg Clin Res."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"726-730","DOI":"10.4103\/1119-3077.154209","article-title":"Complex and compound odontomas: Analysis of 69 cases and a rare case of erupted compound odontoma.","volume":"18","author":"C Bereket","year":"2015","journal-title":"Niger J Clin Pract."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"100-105","DOI":"10.1034\/j.1601-0825.2002.1c778.x","article-title":"A case of complex odontoma associated with an impacted lower deciduous second molar and analysis of the 107 odontomas.","volume":"8","author":"M Hisatomi","year":"2002","journal-title":"Oral Dis."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"430-435","DOI":"10.1111\/j.1834-7819.1987.tb01294.x","article-title":"Odontomes and their behaviour: a review.","volume":"32","author":"C Acton","year":"1987","journal-title":"Aust Dent J."},{"key":"ref-18","first-page":"51-53","article-title":"Unusually large complex odontoma in maxillary sinus associated with unerupted tooth. Report of case and review of literature.","volume":"73","author":"S Singer","year":"2007","journal-title":"N Y State Dent J."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"48-52","DOI":"10.1259\/dmfr\/95388644","article-title":"Complex odontoma associated with dentigerous cyst in maxillary sinus: case report and computed tomography features.","volume":"38","author":"M Sales","year":"2009","journal-title":"Dentomaxillofacial Radiol."},{"key":"ref-20","article-title":"Oral and Maxillofacial Pathology - 4th Edition"},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"390-399","DOI":"10.1016\/j.ajodo.2006.12.023","article-title":"Impacted maxillary central incisor, canine, and second molar with 2 supernumerary teeth and an odontoma.","volume":"135","author":"K Nagaraj","year":"2009","journal-title":"Am J Orthod Dentofacial Orthop."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"750107","DOI":"10.1155\/2013\/750107","article-title":"Molariform Mesiodens in Primary Dentition.","volume":"2013","author":"S Mangalekar","year":"2013","journal-title":"Case Rep Dent."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"93-102","DOI":"10.1093\/ejo\/cjq034","article-title":"Comparison of two cone beam computed tomographic systems versus panoramic imaging for localization of impacted maxillary canines and detection of root resorption.","volume":"33","author":"A Alqerban","year":"2011","journal-title":"Eur J Orthod."},{"key":"ref-24","first-page":"36-42","article-title":"Evaluation of Unerupted Odontomas With Cone Beam Computed Tomography (CBCT).","volume":"2","author":"G G\u00fcrler","year":"2016","journal-title":"J Int Dent Sci."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"20140282","DOI":"10.1259\/dmfr.20140282","article-title":"CBCT in orthodontics: assessment of treatment outcomes and indications for its use.","volume":"44","author":"S Kapila","year":"2015","journal-title":"Dentomaxillofacial Radiol."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"91-95","DOI":"10.1016\/j.oooo.2015.10.014","article-title":"A spatial association between odontomas and the gubernaculum tracts.","volume":"121","author":"M Oda","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"781-787","DOI":"10.2319\/090518-651.1","article-title":"Detection of the gubernacular canal and its attachment to the dental follicle may indicate an abnormal eruption status.","volume":"89","author":"H Ga\u00eata-Araujo","year":"2019","journal-title":"Angle Orthod."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"123-132","DOI":"10.1007\/s12105-011-0253-3","article-title":"Development and Growth of Adenomatoid Odontogenic Tumor Related to Formation and Eruption of Teeth.","volume":"5","author":"F Ide","year":"2011","journal-title":"Head Neck Pathol."},{"key":"ref-29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199285","article-title":"Significance and usefulness of imaging characteristics of gubernaculum tracts for the diagnosis of odontogenic tumors or cysts.","volume":"13","author":"M Oda","year":"2018","journal-title":"PLoS One."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/9-1204\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-1204\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-1204\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T07:05:35Z","timestamp":1615187135000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/9-1204\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,26]]},"references-count":29,"URL":"https:\/\/doi.org\/10.12688\/f1000research.26627.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.54718.r80301","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.54718.r80301","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.54718.r80302","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,26]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/9-1204\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.29393.r72618, Hatem W. Amer, Oral and Maxillo-facial Pathology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt, 17 Nov 2020, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-1204\/v1#referee-response-72618","order":0,"name":"referee-response-72618","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Lubna Elsayed<\/b>; \n<i>Posted: 13 Feb 2021<\/i>; Thank you for your valuable comments and we appreciate your recommendations, and they were considered, a brief description about&nbsp;how the gubernacular canal could affect differential diagnosis both radiographically and histologically was added to the discussion section.","URL":"https:\/\/f1000research.com\/articles\/9-1204\/v2#referee-comment-6360","order":1,"name":"referee-comment-6360","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Lubna Elsayed<\/b>; \n<i>Posted: 23 Feb 2021<\/i>; Thank you for your valuable comments, and your recommendations were considered as we added more literature about similar cases and a discussion about how the gubernacular canal could affect differential diagnosis both radiographically and histologically was added in the discussion section.","URL":"https:\/\/f1000research.com\/articles\/9-1204\/v2#referee-comment-6379","order":2,"name":"referee-comment-6379","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.29393.r78510, Prashanth Panta, Department of Oral Medicine and Radiology, MNR Dental College and Hospital, Sangareddy, Telangana, India, 02 Feb 2021, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/9-1204\/v1#referee-response-78510","order":3,"name":"referee-response-78510","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Lubna Elsayed<\/b>; \n<i>Posted: 13 Feb 2021<\/i>;  \n<i><b>Recommendation 1<\/b>: The 'A 47-year old&nbsp;housewife&nbsp;\u2013 of African origin presented' can be modified as 'A 47-year old female \u2013 of African origin presented'&nbsp;<\/i>  \n<b>Answer:&nbsp;<\/b>Thanks for the recommendation and the change is accepted, although it was a request of the editor to mention \u201coccupation\u201d.  \n<i><b>Recommendation 2:<\/b> Supernumerary tooth and odontoma are also associated with syndromes. If the patient is non-syndromic, the phrase, 'an otherwise healthy and non-syndromic patient,'&nbsp;can be added to the case history section. A brief discussion on the syndromes associated with odontomas and supernumerary teeth may be a valuable addition to this report.<\/i>  \n<b>Answer:<\/b>&nbsp;Thanks for your opinion, it was considered.  \n<i><b>Recommendation 3:<\/b>&nbsp; In the conclusion section, the sentence &quot;Thus,&nbsp;early detection&nbsp;and management of odontomas can help correct any dental irregularity and avoid&nbsp;further complications&quot; have been included. When odontomas are asymptomatic entities and discovered incidentally during radiographic surveys taken for evaluation of missing permanent teeth, how is early detection achievable? Consider adding some info regarding the same and mention which are the further complications.<\/i>  \n<b>Answer:<\/b>\n<b>&nbsp;<\/b>Thanks for the suggestion and further complications were added to the discussion section  \n<i><b>Recommendation 4<\/b>: Since the report mainly circles around GC, the conclusion paragraph could straightaway focus on the GC-odontoma connection. Consider avoiding conventional odontoma literature in conclusion.&nbsp;<\/i>  \n<b>Answer:&nbsp;<\/b>Thanks for the valuable comment and the recommended phrase was added to the conclusion section.  \n<i><b>Recommendation 5:<\/b><b> <\/b>The discussion section can also include a brief review of&nbsp;odontoma-GC literature&nbsp;and&nbsp;appropriate differential diagnosis.&nbsp;<\/i>  \n<b>Answer:&nbsp;<\/b>Thanks for the comment and the suggestion was considered and added to the discussion section.  \n<i><b>Recommendation 6: <\/b>To avoid hype, the word 'unusual' can be removed from the title. The title&nbsp;'Association of the gubernacular canal, supernumerary tooth, and odontoma with an impacted canine on cone-beam computed tomography'&nbsp;seems fitting.<b>&nbsp;&nbsp;<\/b><\/i>  \n<b>Answer:&nbsp;<\/b>Thanks for the suggestion and it was considered.","URL":"https:\/\/f1000research.com\/articles\/9-1204\/v2#referee-comment-6361","order":4,"name":"referee-comment-6361","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.54718.r80301, Ronell Bologna-Molina, Molecular Pathology Area, School of Dentistry, Universidad de la Rep\u00fablica, Montevideo, Uruguay, 26 Feb 2021, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/9-1204\/v2#referee-response-80301","order":5,"name":"referee-response-80301","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This research was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding Program.","order":6,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}